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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 34 (1980), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Incubation of slices of rat cerebral cortical grey matter in Krebs-Ringer bicarbonate-glucose buffer induced a rapid decline in the responsiveness of the adenylate cyclase in subsequently prepared membrane preparations to stimulation by various activators of the enzyme. The loss of responsiveness was time- and temperature-dependent, showed an absolute dependence on extracellular calcium ions and was mimicked by the presence of serine proteases in the incubation medium. The resultant adenylate cyclase preparation was partially responsive to activation by fluoride and guanylylimidodiphosphate but had become virtually unresponsive to activation by ganglioside, trypsin, or β-adrenergic agonists. The loss of responsiveness of adenylate cyclase was not altered if slices were incubated with depolarizing agents, putative neurotransmitters, receptor blockers, serine protease inhibitors, or adenosine deaminase. The nature of the calcium-dependent mechanism involved in the loss responsiveness of membranal adenylate cyclase is unknown. A suggested mechanism for the loss of sensitivity is the action of a membrane-bound, calcium-dependent protease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess patient preferences regarding the treatment of menorrhagia using the multi-attribute utility methodologies, to produce a clinically applicable scale, and to assess health outcomes following treatment of menorrhagia.Methods Women referred to the gynaecology department for the treatment of menorrhagia were interviewed regarding the effects of menorrhagia on different aspects of their life. Their concerns were categorised into main components of health (domains). The relative importance of each domain was rated by the women using importance points which were distributed to represent the perceived importance of each domain. A series of statements (intra-domain statements) was developed for each domain, which described various possible conditions of that component of health. These were also rated using a one metre visual analogue scale with numerical anchor points at zero (worst) and 100 (best).Results The components of health considered most important were, in order of impact, family life, followed by physical health, work life, psychological health, practical difficulties and social life. The scores for the intra-domain statements were combined into a scale to allow the calculation of a final health state utility for a particular outcome based upon the statements the patient chooses within each domain.Discussion In planning treatment for menorrhagia clinicians can assess a woman's current perception of their health, using a simple to administer clinical scale.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 26 (1999), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oxidative damage to growth regulatory proteins has been implicated in the aetiology of psoriasis. However, the transient synthesis of heat shock proteins has been shown to protect cells against the adverse effects of oxidative and other forms of physiological stress. This study has used an hsp72 monoclonal antibody to measure inducible 72 kDa heat shock protein expression in heat stressed normal human skin and established plaque psoriasis. Hsp72 was detected in the basal and suprabasal layer cells of heat-stressed normal skin, and in 12 involved psoriasis lesions. Hsp72 expression was not delected in unstressed normal skin or in 12 cases of uninvolvcd psoriasis. Immunoprecipitation and Western blotting of cell lysates from heat stressed normal skin and involved psoriasis lesions confirmed the presence of a 72 kDa polypeptide with hsp72 immunoreactivity. The MIB-1 monoclonal antibody was used to determine the proliferative fraction of normal and involved psoriastic epidermis. The Ki67 antigen was localised to the nuclei of basal and suprabasal layer cells of normal and involved psoriatic epidermis. Involved psoriatic epidermis contained a higher number of proliferating keratinocytes when compared with normal skin. The study has also demonstrated a strong correlation between hsp72 expression and keratinocyte proliferation in involved psoriatic epidermis (r=0.864, p〈0.001). We believe that the 72 kDa inducible heat shock protein performs a protective function in the proliferative compartment of normal and involved psoriatic skin.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 19 (1996), S. 0 
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 32 (1983), S. 0 
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 32 (1983), S. 0 
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 22 (1975), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Tillites, conglomerates and sandstones occurring in the basal part of the Smalfjord Formation along the Varangerfjord, East Finnmark, North Norway are believed to have formed during the retreat of a glacier.At Kvalnes, on the south side of the fjord, the following sequence, up to 20 m thick, is found: (1) massive monomict tillite interpreted as a subglacial till, (2) massive polymict tillite with lenticular intercalations of stratified sandstone and tillite, interpreted as supraglacial/proglacial drift, (3) polymict conglomerate interstratified with laminated sandstones, interpreted as braided stream deposits. The last named interfingers laterally and is overlain by marine sandstones.At Bigganjargga, near the head of the fjord, a lens of tillite about 3 m thick rests on a striated pavement and is overlain by sandstones and shales. Part of the tillite, containing irregular patches of slightly winnowed tillite, is interpreted as a melt-out till, while a marginal part consisting of inclined tillite beds is interpreted as a series of flow till deposits. The lens is believed to be an oblique section through what was originally an ice-cored moraine ridge. During a subsequent transgression, the moraine was partially eroded, a lag conglomerate was formed, and overlying marine sediments were deposited.Bedded flow tills formed in a supraglacial/proglacial environment may be preserved where the extent of current reworking is very low (such as an isolated end moraine). Stratified conglomerate and sandstone, intimately intercalated with tillite, is to be expected at a glacier margin where glacial meltwater is locally and occasionally abundant, and glacier ablation permits downslope flowage of mobilized supraglacial fluid till.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 38 (1989), S. 0 
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A virus having tubular particles (124, 142 and 167 nm) was manually transmitted from and to Anthoxanthum odoratum (sweet vernal grass). Other experimental hosts were Chenopodium quinoa, C. amaranticolor, Zea mays, Avena sativa and Hordeum vulgare (barley); winter cultivars of barley were more often infected than spring cultivars. In tests which simulated mechanical injury, the virus was transmitted from infected to healthy A. odoratum but not to healthy barley. The virus particles, which were seen as aggregates in the cytoplasm of A. odoratum leaf cells and in anther walls, reacted strongly in immunosorbent electron microscopy tests with antisera to strains of barley stripe mosaic hordeivirus. Nevertheless, the virus could be distinguished from the Type strain of barley stripe mosaic virus by reciprocal serological tests and by symptoms in infected barley cv. Black Hulless. Using an antiserum produced against the virus, a survey of A. odoratum in the field revealed one of 72 tested plants to be naturally infected. The virus is probably that described by Catherall & Chamberlain (1980) and named anthoxanthum latent blanching virus.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 34 (1985), S. 0 
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A spherical virus–like agent ($$32 nm in diameter) was isolated from a plant of Brachypodium sylvaticum (Huds.) Beauv. growing in a botanic garden in England and showing yellow streaks in the leaves. The agent was readily purified and sedimented as a single component in sucrose density rate gradients. The particles had a sedimentation coefficient at infinite dilution of $$122S and a buoyant density of 1.35 g/cm3 in CsCl and 1·33 in CS2SO4. The particles were stable at acid pH but above pH 7·0 in the presence of EDTA dissociated. A protein having a major polypeptide with a molecular weight of $$3·76 × 104 and a species of single stranded RN A with a MW of 1·67 × 106 were detected in the particles. The agent was not transmitted by manual inoculation, by the insects Myzus persicae Sulzer, Rhopalosiphum padi L. or Nephotettix virescens Distant, through soil by leakage from roots or by seed. The particles had physicochemical properties in common with tombus– and sobemoviruses but were not serologically related to 10 members of these groups or to 57 other small spherical RNA plant viruses.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 6 (1979), S. 0 
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Books reviewed in this article. Oral Disease By C. R. Renson. A Colour Atlas of Periodontology By J. D. Strahan and I. M. Waite. Journal of Clinical Engineering ED. BY Morton D. Schwartz. Das Fiefergelenk im Zahnarztlich—Prothetischen Fall By A. H. Geering. Speech Language and Hearing Normal Processes and Disorders By Paul H. Skinner and Ralph L. Shelton.Begg Orthodontic Theory and Technique By P. R. Begg and P. C. Kesling.Removable Orthodontic Appliances By T. M. Graber and B. Neumann.
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