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  • 11
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    A novel two-dimensional coordination polymer: poly[diaquatetra-μ2-chlorido-[μ2-2,2′-(piperazine-1,4-diium-1,4-diyl)diacetate]dicadmium(II)] (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-05-25
    Description: In the crystal structure of the title two-dimensional metal–organic polymeric complex, [Cd 2 Cl 4 (C 8 H 14 N 2 O 4 )(H 2 O) 2 ] n , the asymmetric unit contains a crystallographically independent Cd II cation, two chloride ligands, an aqua ligand and half a 2,2′-(piperazine-1,4-diium-1,4-diyl)diacetate (H 2 PDA) ligand, the piperazine ring centroid of which is located on a crystallographic inversion centre. Each Cd II centre is six-coordinated in an octahedral environment by an O atom from an H 2 PDA ligand and an O atom from an aqua ligand in a trans disposition, and by four chloride ligands arranged in the plane perpendicular to the O—Cd—O axis. The complex forms a two-dimensional layer polymer containing [CdCl 2 ] n chains, which are interconnected into an extensive three-dimensional hydrogen-bonded network by C—H...O, C—H...Cl and O—H...O hydrogen bonds.
    Print ISSN: 0108-2701
    Electronic ISSN: 1600-5759
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by Wiley-Blackwell on behalf of International Union of Crystallography (IUCr).
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  • 12
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    Tumor necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via upregulation of Vegfr3 gene expression in lymphatic endothelial cells (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-06-23
    Description: Lymphangiogenesis is essential in embryonic development but is rare in adults. It occurs, however, in many disease conditions including cancers. Vascular endothelial growth factor-C/D (VEGF-C/D) and VEGF receptor-3 (Vegfr3) play a critical role in the regulation of lymphangiogenesis. We investigated how the VEGF-C/Vegfr3 signalling system is regulated by tumor necrosis factor superfamily, member 15 (Tnfsf15), an endothelium-derived cytokine. We report here that Tnfsf15, which is known to induce apoptosis in vascular endothelial cells, can promote lymphatic endothelial cell (LEC) growth and migration, stimulate lymphangiogenesis, and facilitate lymphatic circulation. Treatment of mouse LEC with Tnfsf15results in upregulation of Vegfr3 expression; this can be inhibited by gene-silencing of death domain–containing receptor-3 (DR3; Tnfrsf25), a cell surface receptor for Tnfsf15, with siRNA, or by blocking Tnfsf15-DR3 interaction with a Tnfsf15 neutralizing antibody 4-3H. Additionally, Tnfsf15/DR3 signalling pathways in LEC include activation of NF-κB. Tnfsf15-overexpressing transgenic mice exhibit a marked enhancement of lymph drainage; this is confirmed by treatment of wild type mice with intraperitoneal injection of recombinant Tnfsf15. Moreover, systemic treatment of pregnant Tnfsf15 transgenic mice with 4-3H leads to inhibition of embryonic lymphangiogenesis. Our data indicate that Tnfsf15, a cytokine produced largely by endothelial cells, facilitates lymphangiogenesis by upregulating Vegfr3 gene expression in LEC, contributing to the maintenance of the homeostasis of the circulatory system. This finding also suggests that Tnfsf15 be of potential value as a therapeutic tool for the treatment of lymphedema.
    Print ISSN: 0022-3417
    Electronic ISSN: 1096-9896
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 13
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    Structural optimizations of U and Z type manifolds for uniform flow distribution by applying increaser and baffle plate (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-09-23
    Description: In this paper, numerical models were established based on the previous experiments for U and Z type manifolds, then investigations were conducted on the effect of the optimized designs on the flow distribution. An increaser and baffle plates are attached to the distribution header respectively for U and Z type manifolds, considering various configurations and sizes. The results indicated that an increaser could obviously reduce non-uniformity with pressure drop being cut down, and baffle plates could also drastically improve the flow distribution, but at the cost of a little pressure drop increase. By comprehensively applying an increaser and baffle plates in Z type, the adverse effect could be eliminated.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell
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  • 14
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    Effects of Different Amount of Crystalline Solvate Molecules on Solid Structures and Photophysical Properties of a Platinum(II) Moiety with 4,4′-Dibromo-2,2′-Bipyridine Ligand (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2016-04-21
    Description: A platinum(II) complex Pt(DiBrbpy)Cl 2 ( 1 ) based on 4,4′-dibromo-2,2′-bipyridine ligand was synthesized and characterized. Interestingly, two solvated phases of 1 with different amounts of crystalline CH 2 Cl 2 molecules, 1· 1/3(CH 2 Cl 2 ) (yellow) and 1· 3/2(CH 2 Cl 2 ) (red), were obtained. In the solid state, 1· 1/3(CH 2 Cl 2 ) exhibits a 3D supramolecular structure based on Pt(DiBrbpy)Cl 2 monomer and emits a weak yellow luminescence at 541 nm (579, sh). In contrast, 1· 3/2(CH 2 Cl 2 ) displays a 2D layer structure based on Pt(DiBrbpy)Cl 2 dimeric units and has a strong red luminescence centered at 624 nm. The results show that crystalline solvate molecule amount can not only influence the packing structures but also photophysical properties of the platinum moiety in solid state. Furthermore, the absorption and luminescence spectra of both phases were studied by TD-DFT calculations.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 15
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    Two Aromatic Ester Organoimido Derivatives of Hexamolybdate: Syntheses, Crystal Structures, and Spectroscopic Studies (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-09-07
    Description: Two alkylimido derivatives of hexamolybdate, (Bu 4 N) 2 [Mo 6 O 18 (≡N- o -COOCH 3 C 6 H 4 )] ( 1 ) and (Bu 4 N) 2 [Mo 6 O 18 (≡N- o -COOCH 2 CH 3 C 6 H 4 )] ( 2 ), were synthesized in high purity and good yields by the reaction of [(C 4 H 9 ) 4 N] 4 [α-Mo 8 O 26 ] and methyl anthranilate or ethyl- o -aminobenzoate hydrochloride with N , N ′-dicyclohexylcarbodiimide (DCC) as a dehydrating agent in dry acetonitrile solution, which were characterized by elemental analyses, IR, UV/Vis, and 1 H NMR spectroscopy as well as ESI-MS, and single-crystal X-ray diffraction study. Compound 1 crystallizes in the monoclinic space group P 2 1 / n with one-dimensional chain structure via intramolecular hydrogen bond. Compound 2 also crystallizes in the monoclinic space group P 2 1 / n with dimer structure by intramolecular hydrogen bonds and π–π interactions between the pairs of cluster anions.
    Print ISSN: 0044-2313
    Electronic ISSN: 1521-3749
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 16
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    The Enantioselective Pharmacokinetics Metabolism of Diniconazole in Quail (Coturnix coturnixs japonica) (2013)
    Wiley-Blackwell
    In: Chirality
    Details
    Publication Date: 2013-09-07
    Description: ABSTRACT The pharmacokinetics of diniconazole enantiomers in quail ( Coturnix coturnix japonica ) were investigated by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Quails were exposed to racemic diniconazole in capsule by oral at dose of 10 mg/kg (body weight). The maximal concentrations observed in blood, heart, liver, and kidney were 3.18, 11.35, 12.32, 15.03 µg/g for S-diniconazole, and 1.13, 3.70, 6.00, 2.60 µg/g for R-diniconazole. The elimination of enantiomers all met the one-compartment model in blood, heart, liver, and kidney well. The elimination half-lives (T 1/2 ) of S-diniconazole were 2.87, 3.85, 5.29, and 4.42 h in blood, heart, liver, and kidney, respectively; the T 1/2 of R-diniconazole were 2.44, 3.42, 146.23, and 74.02 h in blood, heart, liver, and kidney, respectively. The enantiomer fractions (EFs) steadily increased from 0.50 to 0.92 in blood samples and 0.91 in heart samples. Meanwhile, the values increased to 0.70 and 0.80 in liver and kidney initially, and then decreased to 0.33 and 0.44 at the end of the experiment. Metabolism was examined as well and it was found that diniconazole was metabolized to 1, 2, 4-triazole, (E)-3-(1H-1, 2, 4-triazol-1-yl) acrylaldehyde, (E, S)-(R, S)-4-(2, 4-dichlorophenyl)-2, 2-dimethyl-5-(1H-1, 2, 4-triazol-1-yl) pent-4-ene-1, 3-diol, (E)-4-(2, 4-dichlorophenyl)-3-hydroxy-2, 2-dimethyl-5-(1H-1, 2, 4-triazol-1-yl) pent-4-enoic acid, and 1, 3-dichlorobenzen in all samples of quail. Chirality 00:000–000, 2013 . © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0899-0042
    Electronic ISSN: 1520-636X
    Topics: Chemistry and Pharmacology
    Published by Wiley-Blackwell
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  • 17
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    C5a/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis via potentiating Fgl2/fibroleukin expression (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-03-08
    Description: Viral fulminant hepatitis (FH) remains a serious clinical problem with very high mortality. Lacking understand of FH pathogenesis has been in essence hindering efficient clinical treatment. Inferring from a correlation observed between the genetic differences in the complement component 5 (C5) and the susceptibility of mouse strains to murine hepatitis virus strain-3 (MHV-3) infections, we propose that excessive complement activation plays a critical role in the development of FH. We show that MHV-3 infection causes massive complement activation, along with a rapid increase in serum C5a levels and quick development of FH in susceptible strains. Mice deficient of C5a receptor (C5aR) or the susceptible strains treated with C5aR antagonists (C5aRa) exhibit significant attenuation of the disease, accompanying with a remarkable reduction of hepatic fibrinogen-like protein 2 (Fgl2), a hallmark protein that causes necrosis of the infected livers. In accordance, biopsy of FH patients shows a dramatic increase of Fgl2 expression, which correlates with C5aR up-regulation in the liver. In vitro C5a administration accelerates MHV-3-induced Fgl2 secretion by macrophages. Furthermore, inhibiting ERK1/2 and p38 efficiently blocks C5a-mediated Fgl2 production during the viral infections. Conclusions : These data imply, for the first time, that mouse susceptibility to MHV-3-induced FH relies on C5a/C5aR interactions, for which ERK1/2 and p38 pathways participate in up-regulating Fgl2 expression. Inhibition of C5a/C5aR interactions is expected to be beneficial for clinical treatment of FH patients. (H epatology 2014;)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
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  • 18
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    Nepartak Typhoon Influenced Bottom Sediments From the Yangtze River Estuary and Adjacent East China Sea-Foraminiferal Evidence (2018)
    Wiley-Blackwell
    Details
    Publication Date: 2018-03-13
    Description: Foraminiferal taphocoenose characteristics, notably allochthonous tests in surface sediment samples from the Yangtze River Estuary and adjacent areas in the East China Sea, were examined during (July, 2016) and after typhoon Nepartak (February, 2017) crossed this region. A comparison of transport indices from five sample stations reveals that this typhoon significantly strengthened sediment transport, although the transport in predominate direction (TWC north branch) occurs all year. Moreover, findings from a comprehensive impact of currents, topography, test size and shape, as well as other abiotic factors, show that transport occurs in the order (from stronger to weaker): south-north path ≫ southeast-northwest path 〉 nearshore-northeast path. Along the south-north path, the TWC north branch transports larger tests of taxa Ammonia compressiuscula and Cavarotalia annectens as bed load along the gentle seabed in a rolling or saltating process. Results from the southeast-northwest path show smaller and bulging tests of the dominant species Epistominella naraensis and Bolivina robusta may be transported as suspension load along the steep submarine valley by the TWC northwest branch. On the nearshore-northeast path, only part of allochthonous tests Ammonia beccarii vars. was transported, probably due to distance travelled and weakening of the typhoon. Furthermore, we also infer the northeastern area as a sink zone that accumulates grains of allochthonous tests predominantly from the southern source zone, and a selection of tests from littoral species originating from the nearshore source zone. It is important to identify and independently count allochthonous test samples if a large number of these tests are recorded. Findings from this study provide a reference to identify and investigate typhoon modern effects in areas with complex currents and frequent strong physical dynamic events, as well as their geological records.
    Electronic ISSN: 1525-2027
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 19
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    MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting Hedgehog signaling (2017)
    Wiley-Blackwell
    Details
    Publication Date: 2017-09-15
    Description: Chromosome 17p deletions are present in 10% of patients with newly diagnosed multiple myeloma (MM), and are associated with inferior prognosis. miR-324-5p is located on chromosome 17p, and shows diverse functions in different types of cancers. However, its role in MM is largely unknown. Here we found the expression of miR-324-5p was decreased in MM, especially in del(17p) MM. In contrast, the expression of Hedgehog (Hh) signaling components was elevated, indicating a correlation between miR-324-5p and Hh signaling in MM. Hh signaling is important for the pathogenesis of MM and maintenance of MM stem cell compartment. Indeed, overexpression of miR-324-5p significantly decreased Hh signaling components Smo and Gli1, and functionally reduced cell growth, survival as well as stem cell compartment in MM. Moreover, miR-324-5p potentiated the anti-MM efficacy of bortezomib through regulating the activities of multidrug resistance proteins and the expression of Bcl-2 family genes. Consistent results were obtained in vivo . Finally, miR-324-5p overcame the protective effect of bone marrow stromal cells on MM cells. Taken together, our data demonstrate that miR-324-5p is essential for MM pathogenesis and down-regulation of miR-324-5p is a novel mechanism of Hh signaling activation in MM. Therefore, targeting miR-324-5p provides a potential therapeutic strategy for MM. This article is protected by copyright. All rights reserved.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 20
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    A temporal three-dimensional simulation of samarium release in the ionosphere (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2016-09-24
    Description: For understanding plasma processes of the ionosphere and magnetosphere, the alkali and alkaline-earth metals are usually released in space for artificially increasing the electron density. However, it is a limitation that these releases must be in sunlight where the photoionization can take place. In recent years, the lanthanide metals, such as samarium, have been released to produce electrons in reaction with atomic oxygen in the upper space. The reaction could proceed without sunlight so that the restriction on experimental periods is broken. Unfortunately, any sophisticated models even preliminary ones are unavailable yet in the literature. A temporal three-dimensional model is presented for the samarium release in detail with respect to various altitudes and mass. Especially, the plasma diffusion equation is remarkably extended from 2-D to 3-D by importing the influence of geomagnetic declination, which could be also useful for other chemical releases. The field-aligned terms are brought so as to the presented model can describe the diffusion along the geomagnetic field subtly. On the basis of the presented model, behaviors of radio waves propagating through the release area are simulated by using ray tracing. This model could be as the theoretical support for samarium releases and it also helpful for the research on the generation and evolution of the ionosphere irregularities.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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