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  • Articles  (37)
  • Springer  (31)
  • Blackwell Publishing Ltd  (6)
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  • Articles  (37)
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 27 (1997), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Corticosteroid therapy has become the mainstay in the treatment of asthma. However, the risk-benefit balance in the patient calls for assessment of the state of inflammation in the airways. In this respect serum eosinophil cationic protein (ECP) might be a marker, which can easily be measured in a clinical setting. Studies have indicated a relation between level of serum ECP and activity and severity in asthma.Objective To investigate the feasibility to guide steroid therapy on the basis of the level of serum ECP in patients with chronic asthma.Methods Twenty adult patients on maintenance inhaled steroid therapy visited the chest clinic once every 2 months over a 12-month period. At each visit a short history, blood sample for ECP and number of eosinophils, baseline spirometry, and histamine inhalation provocation test (PC20) were obtained. On the basis of level of ECP, adjustments in daily dose of steroids were considered. Data were compared with those of a previous 6-month ECP evaluation study in these same patients.Results In 10 patients mean dose of inhaled steroids was decreased 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA519:ges" location="ges.gif"/〉 25%. ECP rose slightly (antilogged mean from 9.06 to 11.8μg/L) and lung function decreased slightly (mean FEV1%predicted from 85.5 to 81.6). In seven patients mean dose of inhaled or oral (n= 2) steroids was increased 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA519:ges" location="ges.gif"/〉 25%. In this group ECP decreased but remained elevated at 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:09547894:CEA519:ges" location="ges.gif"/〉20μg/L (antilogged mean from 30.5 to 25.6μg/L) and lung function improved (mean FEV1%predicted from 67.2 to 74.5). In both groups patients' scores of asthmatic well-being increased significantly, and PC20 did not show a trend. Exacerbation rate remained the same in the decreased and the no change group (n= 3, in which no substantial change in steroid dose occurred), but was reduced by about 50% in the increased group.Conclusion From this observational study it is concluded that adjusting steroid therapy guided by serum ECP-level may be helpful in tailoring asthma treatment.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 45 (1990), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sera from 204 adult patients with chronic airways obstruction were analysed with the Phadiatop®, a new allergosorbent test with a paper disc containing the most relevant inhalant allergens, the PRIST for total IgE determinations, and a panel of seven RAST tests with the common inhalant allergens in The Netherlands as reference. The aim was to evaluate the Phadiatop as screening test in the in vitro diagnostic procedures in an epidemiological setting. The Phadiatop was classified positive or negative according to percentage binding, total IgE was considered elevated at values 〉 100 kU/1 and the RAST panel positive when at least one RAST result was class 〉 1. The prevalence of inhalant atopy came to 27.9%. The predictive value of the Phadiatop for a positive RAST panel was 96.4%, and for a negative RAST panel 97.3%. For the PRIST these values were 51.9% and 87.2% respectively. The correlation between the log percentages binding of the Phadiatop and the RAST panel was 0.93. It is concluded that the Phadiatop is a valuable test for the screening of inhalant atopy, and as the percentage binding of the Phadiatop may reflect the degree of sensitization it could also be applied as a quantitative measure especially for epidemiological purposes.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 369 (1981), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Ground water monitoring & remediation 8 (1988), S. 0 
    ISSN: 1745-6592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 34 (1986), S. 0 
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The complete sequence of the plasmid pHly152-encoded hemolysin (hly) determinant of Escherichia coli is presented and compared with a recently sequenced chromosomal hly determinant [1]. High sequence homology between the two hly determinants is observed withìn all four structural genes, hlyC, A, B and D, but little sequence similarities are found in the 3′- and 5′-noncoding flanking regions. In addition, the noncoding region upstream of hlyC which carries the promoter for hlyC, A and B, was sequenced for several chromosomal hly determinants. The comparison of these sequences indicates three distinct classes of promoter regions which share common putative −10 and −35 boxes at roughly the same location relative to the start of hlyC.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 706-712 
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Tuberkulose ; Impfung ; BCG ; Key words Tuberculosis ; Vaccine ; BCG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Tuberculosis is, on a global level, still one of the most important infectious diseases. Effective control of tuberculosis could probably be achieved by a combination of chemotherapy and vaccination. Although a vaccine (BCG) is available, it cannot prevent the development of tuberculosis of the lungs in adults as the most frequent disease manif- estation. The development of a new vaccine against tuberculosis therefore remains a primary goal. Because the immune defense against M. tuberculosis depends on different T-cell subpopulations, the optimal combination has to be stimulated to achieve protection. Because one third of the world population is already infected with M. tubercolosis, possibly two vaccines are needed: one therapeutic vaccine to fight an already estab- lished infection and a preventive vaccine. Currently different vaccine candidates are under development. It is still to early to predict, which may be successful.
    Notes: Zusammenfassung Die effektive Kontrolle der Tuberkulose, die noch immer zu den weltweit bedeutendsten Infektionskrankheiten zählt, wird am ehesten durch eine Kombination aus Chemotherapie und Impfung erreicht. Mit BCG steht zwar ein Impfstoff zur Verfügung, der jedoch den Ausbruch der Lungentuberkulose bei Erwachsenen als häufigste Erkrankungsform nicht verhindern kann. Die Entwicklung eines neuen Impfstoffs gegen Tuberkulose ist daher vorrangiges Ziel. Da die Infektabwehr von unterschiedlichen T-Zellpopulationen getragen wird, muß angestrebt werden, die für den Schutz optimale Kombination zu stimulieren. Ein Drittel der Weltbevölkerung ist mit dem Erreger bereits infiziert, so daß möglicherweise zwei Impfstoffe benötigt werden: einer zur Bekämpfung der bereits etablierten Infektion (Infektionstherapie) und ein anderer zur raschen Erregerabwehr nach Erstkontakt (Infektionsprävention). Derzeit werden unterschiedliche Impfstoffkandidaten entwickelt, deren Erfolgschancen noch schwer abzuschätzen sind.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 357 (1998), S. 191-196 
    ISSN: 1432-1912
    Keywords: Key words Mouse ; Stomach ; bradykinin ; Knockout B2 receptor ; B1 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate the pharmacological profile of the kinin B1 and B2 receptors in isolated stomachs from wild-type control and B2 receptor knockout mice. Isometric contractions evoked by bradykinin (BK) (9 nM) and desArg9BK (28 nM) were shown to be different. The contraction induced by desArg9BK had a longer duration than that evoked by BK and increased during incubation in vitro in stomachs of wild-type controls, while in the transgenic B2 receptor knockout mice, the contractions evoked by desArg9BK and BK were similar and followed the B1 receptor agonist pattern. BK but not the carboxypeptidase-resistant analog, [Phe8ψ(CH2-NH)Arg9]BK, was found to be active in the stomach of B2 receptor knockout mice. BK-induced contractions were prevented by mergetpa (a carboxypeptidase M inhibitor) (10 μM) and by a the B1 receptor antagonist, AcLys[DβNal7,Ile8]desArg9BK (R 715) (0.88 μM), while not being influenced by the B2 receptor antagonist HOE 140 (0.38 μM). BK and [Phe8ψ(CH2-NH)Arg9]BK were potent contractants of the wild-type mice stomach and their effects were not influenced by mergetpa or by the B1 receptor antagonist: they were reduced by HOE 140. After incubation in vitro for 3–4 hours, the tissues were treated with HOE 140 (4 μM) and FR-173657 (17 μM) to eliminate B2 receptor function. In these tissues, BK evoked a B1-like contraction which was inhibited by mergetpa (10 μM) and antagonized by R 715 (8 μM). The results indicate that BK acts primarily on B2 receptors. However, after intramural conversion to desArg9BK, activation of B1 receptors of the mice stomach occurs. In the tissues of B2 receptor knockout mice, BK behaves as a pure B1 receptor agonist while in stomachs of control animals, the B2 receptor contribution is overwhelming. After complete blockade of the B2 receptor, BK is able to evoke B1-mediated responses similar to those observed in tissues of B2 receptor knockout mice. It is concluded that the disruption of the B2 receptor gene eliminates the B2 receptor without influencing the B1 receptor system.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 197 (1940), S. 204-209 
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Überblickt man die gesamten hier mitgeteilten Versuchsergebnisse, so kann man folgendes feststellen: Die Alkoholnarkose läßt sich durch Cardiazol, Coramin, Pervitin und Cycliton antagonistisch beeinflussen. Bei Cardiazol ergibt sich ein Optimum mit guter Weckwirkung in der Dosierung von 2,5 mg/100 g. Die höhere Dosierung von 5 mg hat geringere Weckwirkung. Auch bei Coramin ist ein Optimum bei 15 mg vorhanden, während die höhere Dosierung von 30 mg synergistisch mit dem Alkohol wirkt, im Sinne einer Verlängerung der Narkose. In gleicher Weise verkürzte auch Pervitin die Alkoholnarkose, eine lähmende Wirkung bei höherer Dosierung war nicht erkennbar. Cycliton wirkte in der niedrigeren Dosierung antagonistisch, während höhere Dosen wie bei Coramin die narkotische Wirkung des Alkohols verstärkten. Auf die Chloralosenarkose wirkte keines der Analeptica antagonistisch ein, doch war die Beurteilung durch die starke Reflexerregbarkeit, die die Chloralose hervorrief, praktisch unmöglich. Cardiazol und Pervitin verlängerten beide etwas die Narkose. Coramin und Cycliton wirkten ausgesprochen toxisch, sie töteten schon in niedrigen Gaben eine große Zahl der Tiere in der Chloralosenarkose.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Gynäkologe 32 (1999), S. 377-385 
    ISSN: 1433-0393
    Keywords: Key words Pregnancy • Delivery • Adult congenital ; heart disease ; Schlüsselwörter Schwangerschaft • Angeborene Herzfehler • Erwachsene • Entbindung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Prognose angeborener Herzfehler hat sich in den letzten Jahrzehnten dramatisch verbessert. Gleichzeitig hat auch die Zahl von Frauen, die mit einem angeborenen Herzfehler schwanger werden, so stark zugenommen, daß diese inzwischen 30–50 % aller kardialen Erkrankungen bei Schwangeren ausmachen. Die Mehrzahl der Patientinnen mit angeborenen Herzfehlern hat eine oder mehrere Korrekturoperationen überstanden. Angeborene Herzfehler in ihrer nativen Form, kommen wesentlicher seltener vor. Während der Schwangerschaft kommt es zu Umstellungsreaktionen, die – in Abhängigkeit vom zugrundeliegenden Herzfehler – die Hämodynamik in unterschiedlicher Weise beeinflussen. Die veränderte Hämodynamik muß für jeden Herzfehler gesondert abgeschätzt werden und erfordert eine individuelle Betreuung der Patientinnen. Probleme betreffen die Auswirkung der Schwangerschaft auf die Grunderkrankung, sowie die Auswirkung der Grunderkrankung auf den Schwangerschaftsverlauf und den Fetus. Die Schwangerenberatung beinhaltet Informationen über genetische Risiken, potentiell teratogene Substanzen, Schwangerschaftsverlauf, Entbindung und postpartale Nachsorge. Heutzutage können die meisten Patientinnen mit angeborenen Herzfehlern eine Schwangerschaft gut bewältigen, wenn eine enge Kooperation zwischen Kardiologen und Gynäkologen gewährleistet ist.
    Notes: Summary Because of advances in medical treatment and surgical management the number of adolescent females with congenital heart disease increased significantly during the last decade. On the other hand, the incidence of rheumatic heart disease, which accounted for the largest number of pregnant women with heart disease in the past, has declined over the years. Pregnancy is associated with a lot of physiological adjustments, such as changes in blood volume, stroke volume and cardiac output and may result in deleterious clinical effects in patients with congenital heart disease. Although a good outcome for these woman can often be expected, congenital heart disease still represents a high-risk pregnancy for both mother and infant. The actual risk depends on the type of malformation and functional impairment of the mother. To accompany these women safely through pregnency, good cooperation between pediatric and adult cardiologists, obstetrician and other physicians is necessary.
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