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  • risk assessment  (5)
  • basement membranes  (2)
  • Springer  (7)
  • Blackwell Publishing Ltd
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  • Springer  (7)
  • Blackwell Publishing Ltd
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  • 1
    Electronic Resource
    Electronic Resource
    Early biosynthetic changes in the diabetic-like retinopathy of galactose-fed rats (1996)
    Springer
    Diabetologia 39 (1996), S. 735-738 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic retinopathy ; basement membranes ; collagen IV ; fibronectin ; gene expression.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histological lesions of diabetic microangiopathy have a long latency, but vascular cell function may be affected at early stages of the process. Rats with experimental galactosaemia develop a diabetic-like retinopathy in the absence of other metabolic abnormalities characteristic of diabetes mellitus; basement membrane thickening is measurable in their retinal vessels after 7 months of galactose feeding. To examine the course of biosynthetic changes relevant to the process, retinal expression of collagen IV and fibronectin were compared in rats fed a 30 % galactose diet or a control diet for 5 or 9 weeks. Total retinal RNA was studied by reverse transcription-polymerase chain reaction; the fibronectin primers encompassed the alternatively spliced EIIIA exon. The levels of α1 (IV) collagen and fibronectin mRNAs were measured relative to an internal standard (β -actin mRNA). The proportion of EIIIA + to EIIIA− fibronectin transcripts was similar in the retinas of control and galactose-fed rats, which, however, showed increased levels of both fibronectin and collagen IV mRNAs in the presence of unchanged β -actin mRNA levels. An upward trend was detected by 5 weeks of galactose feeding; and after 9 weeks the fibronectin/actin ratio was 1.2 ± 0.3 vs 0.8 ± 0.2 in controls (p = 0.015) and the collagen IV/actin ratio was 1.3 ± 0.3 vs 0.9 ± 0.2 in controls (p = 0.04). Thus, hyperhexosaemia of a few weeks' duration is a perturbation sufficient to increase the synthesis of basement membrane components in the retina. The search for additional early biosynthetic changes should assist in reconstructing the pathogenesis of hexose-induced retinal microangiopathy. [Diabetologia (1996) 39: 735–738]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050503
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  • 2
    Electronic Resource
    Electronic Resource
    Early biosynthetic changes in the diabetic-like retinopathy of galactose-fed rats (1996)
    Springer
    Diabetologia 39 (1996), S. 735-738 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic retinopathy ; basement membranes ; collagen IV ; fibronectin ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histological lesions of diabetic microangiopathy have a long latency, but vascular cell function may be affected at early stages of the process. Rats with experimental galactosaemia develop a diabetic-like retinopathy in the absence of other metabolic abnormalities characteristic of diabetes mellitus; basement membrane thickening is measurable in their retinal vessels after 7 months of galactose feeding. To examine the course of biosynthetic changes relevant to the process, retinal expression of collagen IV and fibronectin were compared in rats fed a 30% galactose diet or a control diet for 5 or 9 weeks. Total retinal RNA was studied by reverse transcription-polymerase chain reaction; the fibronectin primers encompassed the alternatively spliced EIIIA exon. The levels of α1 (IV) collagen and fibronectin mRNAs were measured relative to an internal standard (Β-actin mRNA). The proportion of EIIIA+ to EIIIA− fibronectin transcripts was similar in the retinas of control and galactose-fed rats, which, however, showed increased levels of both fibronectin and collagen IV mRNAs in the presence of unchanged Β-actin mRNA levels. An upward trend was detected by 5 weeks of galactose feeding; and after 9 weeks the fibronectin/actin ratio was 1.2±0.3 vs 0.8±0.2 in controls (p=0.015) and the collagen IV/actin ratio was 1.3±0.3 vs 0.9±0.2 in controls (p=0.04). Thus, hyperhexosaemia of a few weeks' duration is a perturbation sufficient to increase the synthesis of basement membrane components in the retina. The search for additional early biosynthetic changes should assist in reconstructing the pathogenesis of hexose-induced retinal microangiopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418547
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  • 3
    Electronic Resource
    Electronic Resource
    Euro Chlor Risk Assessment for the Marine Environment Osparcom Region: North Sea - Trichloroethylene (1998)
    Springer
    Environmental monitoring and assessment 53 (1998), S. 467-487 
    Details
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; trichloroethylene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on trichloroethylene (TRI) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 19 studies for fish, 30 studies for invertebrates and 14 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 150 µg/l. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.1 µg TRI/l water and a worst case PEC of 3.5 µg TRI/l water. The calculated PEC/PNEC ratios give a safety margin of 40 to 1,500 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern for food chain accumulation is expected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006066600350
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  • 4
    Electronic Resource
    Electronic Resource
    Euro Chlor Risk Assessment for the Marine Environment Osparcom Region: North Sea - Chloroform (1998)
    Springer
    Environmental monitoring and assessment 53 (1998), S. 401-424 
    Details
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; chloroform
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on chloroform was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 23 studies for fish, 17 studies for invertebrates and 10 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a typical PNEC value of 72 µg/l. Due to limitations of the studies evaluated, a worst PNEC of 1 µg/l could also be used. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.2 µg chloroform per litre of water and a worst case PEC of 5 to 11.5 µg chloroform per litre of water. The calculated PEC/PNEC ratios give a safety margin of 6 to 360 between the predicted no effect concentration and the exposure concentrations. A worst case ratio, however, points to a potential risk for sensitive species. Refinement of the assessment is necessary by looking for more data. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006010515371
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  • 5
    Electronic Resource
    Electronic Resource
    Euro Chlor Risk Assessment for the Marine Environment Osparcom Region: North Sea - Tetrachloroethylene (1998)
    Springer
    Environmental monitoring and assessment 53 (1998), S. 489-508 
    Details
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; tetrachloroethylene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on tetrachloroethylene (PER) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 18 studies for fish, 13 studies for invertebrates and 8 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 51 µg/l. Most of the available monitoring data apply to rivers and estuary waters and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.2 µg PER/l water and a worst case PEC of 2.5 µg PER/l water. The calculated PEC/PNEC ratios give a safety margin of 20 to 250 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006018717188
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  • 6
    Electronic Resource
    Electronic Resource
    Euro Chlor Risk Assessment for the Marine Environment Osparcom Region: North Sea - 1,1,2-Trichloroethane (1998)
    Springer
    Environmental monitoring and assessment 53 (1998), S. 447-466 
    Details
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; marine ; environmental ; exposure ; aquatic toxicity ; monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on 1,1,2-trichloroethane (T112) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 22 studies for fish, 45 studies for invertebrates and 9 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 300 µg/l. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.01 µg T112/l water and a worst case PEC of 5 µg T112/l water. The calculated PEC/PNEC ratios give a safety margin of 60 to 30,000 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006014616279
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  • 7
    Electronic Resource
    Electronic Resource
    Euro Chlor Risk Assessment for the Marine Environment Osparcom Region: North Sea - 1,2-Dichloroethane (1998)
    Springer
    Environmental monitoring and assessment 53 (1998), S. 425-445 
    Details
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; 1,2-dichloroethane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on 1,2-dichloroethane (EDC) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 21 studies for fish, 17 studies for invertebrates and 7 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 1100 µg/l. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.5 µg EDC/l and a worst case PEC of 6.4 µg EDC/l. The calculated PEC/PNEC ratios give a safety margin of 170 to 2200 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006062532209
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    Paper (German National Licenses)
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