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  • risk assessment  (5)
  • Electron Microscopy  (2)
  • Springer  (7)
  • Blackwell Publishing Ltd
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  • Springer  (7)
  • Blackwell Publishing Ltd
Years
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 24 (1973), S. 345-349 
    ISSN: 1432-0533
    Keywords: Cockayne's Syndrome ; Peripheral Nerve ; Electron Microscopy ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of sural nerve biopsies was studied in two sisters with Cockayne's syndrome. Both had severe physical and mental retardation and evidence of peripheral neuropathy. Striking alterations in the myelin sheath with relative preservation of the axis cylinder were noted in both. There were also electron dense bodies in the Schwann cells. These findings support the suggestion that Cockayne's syndrome may be a form of leukodystrophy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Steele-Richardson-Olszewski Syndrome ; Progressive Supranuclear Palsy ; Neurofibrillary Tangles ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neurofibrillary tangles found in the neurons of a case of Steele-Richardson-Olszewski syndrome were studied by electron microscopy. Both the flame-shaped and globose type of tangles were present. The neurofibrillary tangles were composed of bundles of straight tubules measuring approximately 150 Å in diameter. This ultrastructural appearance of the tangles in Steele-Richardson-Olszewski syndrome is different from the appearance of tangles found in other neurological disorders and is probably indicative of intraneuronal accumulation of a new type of fibrous protein.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; trichloroethylene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on trichloroethylene (TRI) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 19 studies for fish, 30 studies for invertebrates and 14 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 150 µg/l. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.1 µg TRI/l water and a worst case PEC of 3.5 µg TRI/l water. The calculated PEC/PNEC ratios give a safety margin of 40 to 1,500 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern for food chain accumulation is expected.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; chloroform
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on chloroform was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 23 studies for fish, 17 studies for invertebrates and 10 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a typical PNEC value of 72 µg/l. Due to limitations of the studies evaluated, a worst PNEC of 1 µg/l could also be used. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.2 µg chloroform per litre of water and a worst case PEC of 5 to 11.5 µg chloroform per litre of water. The calculated PEC/PNEC ratios give a safety margin of 6 to 360 between the predicted no effect concentration and the exposure concentrations. A worst case ratio, however, points to a potential risk for sensitive species. Refinement of the assessment is necessary by looking for more data. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; tetrachloroethylene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on tetrachloroethylene (PER) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 18 studies for fish, 13 studies for invertebrates and 8 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 51 µg/l. Most of the available monitoring data apply to rivers and estuary waters and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.2 µg PER/l water and a worst case PEC of 2.5 µg PER/l water. The calculated PEC/PNEC ratios give a safety margin of 20 to 250 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; marine ; environmental ; exposure ; aquatic toxicity ; monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on 1,1,2-trichloroethane (T112) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 22 studies for fish, 45 studies for invertebrates and 9 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 300 µg/l. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.01 µg T112/l water and a worst case PEC of 5 µg T112/l water. The calculated PEC/PNEC ratios give a safety margin of 60 to 30,000 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-2959
    Keywords: risk assessment ; chlorinated compound ; environmental ; marine ; exposure ; aquatic toxicity ; monitoring ; 1,2-dichloroethane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This risk assessment on 1,2-dichloroethane (EDC) was carried out specifically for the marine environment, according to the methodology laid down in the EU risk assessment Regulation (1488/94) and the Guidance Document of the EU New and Existing Substances Regulation (TGD, 1997). The study consists of the collection and evaluation of data on effects and environmental concentrations from analytical monitoring programs in large rivers and estuaries in the North Sea area. The risk is indicated by the ratio of the "predicted environmental concentrations" (PEC) and the "predicted no effect concentrations" (PNEC) for the marine aquatic environment. In total, 21 studies for fish, 17 studies for invertebrates and 7 studies for algae have been evaluated. Both acute and chronic toxicity studies have been taken into account and the appropriate assessment factors have been used to define a PNEC value of 1100 µg/l. Most of the available monitoring data apply to rivers and estuaries and were used to calculate PECs. The most recent data (1991-1995) support a typical PEC of 0.5 µg EDC/l and a worst case PEC of 6.4 µg EDC/l. The calculated PEC/PNEC ratios give a safety margin of 170 to 2200 between the predicted no effect concentration and the exposure concentration. Additional evaluation of environmental fate and bioaccumulation characteristics showed that no concern is expected for food chain accumulation.
    Type of Medium: Electronic Resource
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