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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Multiple forms of calf brain N-acetyl-β-hexosaminidases (β-2-acetamido-2- deoxy-d-glucoside acetamidodeoxyglucohydrolase EC 3.2.1.30) were separated on starch gel electrophoresis at pH 5.8. The organ specific electrophoretic patterns did not depend on the cell fraction studied. Much of the activity is only separated with difficulty from particulate matter. Two major and one minor component were separated on DEAE-cellulose chromatography at pH 5.8. Each component had both N-acetyl-β-galactosaminidase and N-acetyl-β-glucosaminidase activity. The ratio of these two activities was unaffected by the presence of N-ethylmaleimide or dithiothreitol. The forms were also examined by isoelectric focusing when at least four components were recognized: isoelectric at 4.9, 6.0, 6.3 and 6.8. Interconversion of the 4.9 form to that isoelectric at pH 6.0 was noted during vacuum dialysis. Samples from normal human brain and from cases of Tay-Sachs disease were also examined and the results compared.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 45 (1990), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 38 (1976), S. 0 
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The factors affecting the absorption and translocation of 14C-dalapon (2.2-dichloropropionic acid) in johnsongrass were studied. Johnsongrass [Sorghum halepense (L.) Pers.] was first pot-grown in a greenhouse and then treated and placed in controlled-environment chambers.Absorption of 14C-dalapon into johnsongrass leaves and subsequent translocation occurred continuously within the plant during a 48-h period after treatment. Gas chromatographic analysis of johnsongrass extracts showed that the dalapon molecule was translocated intact. Absorption and translocation of 14C-dalapon increased as the droplet volume of the diluent was increased from 0.2 to 5.0 μl per treated spot.At 21 and 32°C, translocation of 14C-dalapon from a 2-cm treated leaf section into the plant was greater at 100% than at 35% relative humidity. At 38°C, translocation was greater at 35% than at 100% relative humidity. The addition of 0.5% surfactant to the dalapon solution increased translocation under all environmental conditions studied. The addition of 0.1 M KH2PO4 to dalapon-surfactant solutions increased 4-dalapon translocation under high temperature (38°C), especially at 35% relative humidity.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 31 (1996), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of basic fibroblast growth factor (bFGF) in periodontal ligament (PDL) tissue was investigated in samples which were obtained from freshly extracted human teeth. The PDL tissue was collected by scraping, and bFGF was identified and localized by immunohistochemistry. Fibroblasts. endothelial cells, some fibrocytes and extracellular matrix (ECM) stained positively for bFGF It was observed that cells from healthy PDL stained more intensely than those from PDL of teeth associated with chronic periodontitis; histological cell counts revealed that the numbers of fibroblasts was greater (p〈0.0005) in healthy PDL than in diseased PDL tissue. The results of this study show that bFGF is produced primarily by PDL fibroblasts and endothelial cells in the PDL and that bFGF levels may be decreased in tissue associated with chronic periodontal lesions.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] We identified a human mutation that causes dilated cardiomyopathy and heart failure preceded by sensorineural hearing loss (SNHL). Unlike previously described mutations causing dilated cardiomyopathy that affect structural proteins, this mutation deletes 4,846 bp of the human transcriptional ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 246 (1973), S. 155-156 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Structures variously called Querbalken, crossbands, and annuli have been reported in Caulobacter stalks since they were first observed in the electron microscope8-6. This study was undertaken to determine how the formation of these structures is related to the life cycle of the bacterium. ...
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  • 7
    Publication Date: 2014-06-12
    Description: The 2014 Working Group on California Earthquake Probabilities (WGCEP14) present the time-independent component of the Uniform California Earthquake Rupture Forecast, Version 3 (UCERF3), which provides authoritative estimates of the magnitude, location, and time-averaged frequency of potentially damaging earthquakes in California. The primary achievements have been to relax fault segmentation and include multifault ruptures, both limitations of UCERF2. The rates of all earthquakes are solved for simultaneously and from a broader range of data, using a system-level inversion that is both conceptually simple and extensible. The inverse problem is large and underdetermined, so a range of models is sampled using an efficient simulated annealing algorithm. The approach is more derivative than prescriptive (e.g., magnitude–frequency distributions are no longer assumed), so new analysis tools were developed for exploring solutions. Epistemic uncertainties were also accounted for using 1440 alternative logic-tree branches, necessitating access to supercomputers. The most influential uncertainties include alternative deformation models (fault slip rates), a new smoothed seismicity algorithm, alternative values for the total rate of M w ≥5 events, and different scaling relationships, virtually all of which are new. As a notable first, three deformation models are based on kinematically consistent inversions of geodetic and geologic data, also providing slip-rate constraints on faults previously excluded due to lack of geologic data. The grand inversion constitutes a system-level framework for testing hypotheses and balancing the influence of different experts. For example, we demonstrate serious challenges with the Gutenberg–Richter hypothesis for individual faults. UCERF3 is still an approximation of the system, however, and the range of models is limited (e.g., constrained to stay close to UCERF2). Nevertheless, UCERF3 removes the apparent UCERF2 overprediction of M  6.5–7 earthquake rates and also includes types of multifault ruptures seen in nature. Although UCERF3 fits the data better than UCERF2 overall, there may be areas that warrant further site-specific investigation. Supporting products may be of general interest, and we list key assumptions and avenues for future model improvements.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 8
    Publication Date: 2014-06-12
    Description: We generalize the formulation of probabilistic seismic hazard analysis to accommodate simulation-based hazard models by expressing the joint probability distribution among the parameters of a kinematically complete earthquake rupture forecast in terms of a conditional hypocenter distribution and a conditional slip distribution. The seismological hierarchy implied by these dependencies allows the logarithmic excitation functional to be exactly and uniquely decomposed into a series of uncorrelated terms that include zero-mean averages of the site, source, hypocenter, and source-complexity effects. We use this averaging-based factorization to compare the CyberShake prototype hazard model developed by the Southern California Earthquake Center, CS11, with the empirical ground-motion prediction equations (GMPEs) of the 2008 Next Generation Attenuation (NGA08) project. For horizontal-response spectral accelerations at long periods (2–10 s), the basin and directivity effects of CS11 are substantially larger than those of the NGA08 GMPEs. Directivity–basin coupling and other 3D wave propagation effects not represented in the GMPEs contribute significantly to the excitation patterns in CS11. The total variance of the CS11 excitations is about 60% higher than the NGA root mean square (rms) at the 2 s period but almost 30% lower at 10 s. Relative to the NGA rms, the residual variance in CS11 at 2 s is larger than the aleatory variability in the NGA08 database by a factor of nearly 1.6. Recent CyberShake experiments with alternative source and structural models suggest that the high CS11 variances are due to an overestimation of the basin and directivity effects at short periods. The CyberShake site and path effects unexplained by the NGA08 models account for 40%–50% of total residual variance, suggesting that improvements to the simulation-based hazard models could reduce the aleatory variability intrinsic to the current GMPEs by as much as 25%.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 9
    Publication Date: 2015-01-30
    Description: We derive time-dependent, renewal-model earthquake probabilities for the case in which the date of the last event is completely unknown, and compare these with the time-independent Poisson probabilities that are customarily used as an approximation in this situation. For typical parameter values, the renewal-model probabilities exceed Poisson results by more than 10% when the forecast duration exceeds ~20% of the mean recurrence interval. We also derive probabilities for the case in which the last event is further constrained to have occurred before historical record keeping began (the historic open interval), which can only serve to increase earthquake probabilities for typically applied renewal models. We conclude that accounting for the historic open interval can improve long-term earthquake rupture forecasts for California and elsewhere.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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  • 10
    Publication Date: 2014-12-05
    Description: The Regional Earthquake Likelihood Models experiment in California tested the performance of earthquake likelihood models over a five-year period. First-order analysis showed a smoothed-seismicity model by Helmstetter et al. (2007) to be the best model. We construct optimal multiplicative hybrids involving the best individual model as a baseline and one or more conjugate models. Conjugate models are transformed using an order-preserving function. Two parameters for each conjugate model and an overall normalizing constant are fitted to optimize the hybrid model. Many two-model hybrids have an appreciable information gain (log probability gain) per earthquake relative to the best individual model. For the whole of California, the Bird and Liu (2007) Neokinema and Holliday et al. (2007) pattern informatics (PI) models both give gains close to 0.25. For southern California, the Shen et al. (2007) geodetic model gives a gain of more than 0.5, and several others give gains of about 0.2. The best three-model hybrid for the whole region has the Neokinema and PI models as conjugates. The best three-model hybrid for southern California has the Shen et al. (2007) and PI models as conjugates. The information gains of the best multiplicative hybrids are greater than those of additive hybrids constructed from the same set of models. The gains tend to be larger when the contributing models involve markedly different concepts or data. These results need to be confirmed by further prospective tests. Multiplicative hybrids will be useful for assimilating other earthquake-related observations into forecasting models and for combining forecasting models at all timescales.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
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