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  • Nature Publishing Group  (2)
  • Blackwell Publishing Ltd/Inc.  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    The Potential Role of Mannan-Binding Lectin in the Clearance of Self-Components Including Immune Complexes (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Scandinavian journal of immunology 60 (2004), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mannan-binding lectin (MBL) is a pattern recognition receptor in the innate immune system. It recognizes certain sugar residues arranged in a pattern that enables MBL to bind with sufficient strength. Such sugar patterns are common on the surface of many microorganisms, and MBL has therefore been considered to be an agent that can discriminate between self and nonself. There is, however, increasing evidence supporting that MBL, like many membrane-bound C-type lectin-like receptors, also helps to dispose of various outworn or abnormal body components. Most self-components are protected with sialic acid or galactose that disrupt the pattern of the sugars that MBL can bind, but MBL may be significantly involved in the elimination of self-components that have lost these protective terminal residues. The role of MBL in the clearance of invading pathogens has previously been thoroughly reviewed. Here, we review some findings that support the notion that MBL may contribute to noninflammatory removal of immune complexes and abnormal cells by the reticuloendothelial system. Defects in this clearance mechanism may cause an accumulation of potentially dangerous self-components, thereby increasing the likelihood of chronic inflammation and autoimmunity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0300-9475.2004.01437.x
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  • 2
    Electronic Resource
    Electronic Resource
    Specificity of transfer factor (1976)
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 250-250 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN an article on the use of transfer factor (TF) in treatment of viral infections1, Zuckerman states that "clinically, TF activates uncommitted and non-sensitised lymphocytes of the recipient so that new clones of antigen-specific cells are produced". He goes on to make the point that the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/259250b0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Measles virus receptor on human T lymphocytes (1975)
    [s.l.] : Nature Publishing Group
    Nature 255 (1975), S. 554-556 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A cell line carrying measles virus (Mc-Lu 106) (ref. 7) was used and uninfected control cells (Lu 106) of the same origin. Binding of measles virus to human lymphocytes was demonstrated by a resetting technique. Monolayers of infected and uninfected cells were trypsinised and incubated at 37 C in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/255554a0
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    Paper (German National Licenses)
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