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  • Blackwell Publishing Ltd  (14)
  • Newark :John Wiley & Sons, Incorporated,  (5)
  • Biological and Chemical Oceanography Data Management Office (BCO-DMO). Contact: bco-dmo-data@whoi.edu  (1)
  • Macmillan Magazines Ltd.  (1)
  • 1
    Online Resource
    Online Resource
    Wiley-Schnellkurs Organische Chemie I Grundlagen. (2021)
    Newark :John Wiley & Sons, Incorporated,
    Details
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (374 pages)
    Edition: 2nd ed.
    ISBN: 9783527835447
    Series Statement: Wiley Schnellkurs Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6523413
    Language: German
    Note: Intro -- Titelblatt -- Impressum -- Inhaltsverzeichnis -- Einführung -- Braucht man für die Organische Chemie lediglich ein gutes Gedächtnis? -- Die Handlung -- Wie Sie dieses Buch benutzen können -- Wie Sie am besten lernen -- 1 Skelettformeln zeichnen -- Skelettformeln lesen -- Skelettformeln zeichnen -- Fehler vermeiden -- Weitere Übungen -- Formalladungen identifizieren -- Freie Elektronenpaare aufspüren, die nicht eingezeichnet sind -- 2 Resonanz -- Was ist Resonanz? -- Geschwungene Pfeile: Die Werkzeuge zum Zeichnen von Resonanzstrukturen -- Die zwei Gebote -- Gute Pfeile zeichnen -- Formalladungen in Resonanzstrukturen -- Resonanzstrukturen zeichnen - Schritt für Schritt -- Resonanzstrukturen zeichnen - durch Mustererkennung -- Die relative Bedeutung von Resonanzstrukturen abschätzen -- 3 Säure-Base-Reaktionen -- Faktor 1 - Welches Atom trägt die Ladung? -- Faktor 2 - Resonanz -- Faktor 3 - der Induktive Effekt -- Faktor 4 - Orbitale -- Die vier Faktoren in eine Rangfolge bringen -- Quantitative Messung (pKS-Werte) -- Die Lage des Gleichgewichts bestimmen -- Reaktionsverläufe veranschaulichen - Reaktionsmechanismen -- 4 Geometrie -- Orbitale und Hybridisierungszustände -- Der räumliche Bau -- Freie Elektronenpaare -- 5 Nomenklatur -- Stoffklasse -- Grad der Ungesättigtheit -- Der Stammname - oder: die Hauptkette benennen -- Substituenten benennen -- Stereoisomerie -- Nummerieren -- Trivialnamen -- Von einem Namen auf eine Struktur schließen -- 6 Konformationen -- Wie Sie eine Newman-Projektion zeichnen -- Die Stabilität verschiedener Konformationen anhand von Newman-Projektionen bewerten -- Sesselkonformationen zeichnen -- Substituenten am Sessel platzieren -- Eine Ringinversion durchführen -- Die Stabilität der Sessel vergleichen -- Lassen Sie sich nicht von der Nomenklatur verwirren -- 7 Konfigurationen -- Chiralitätszentren aufspüren. , Die Konfiguration eines Chiralitätszentrums bestimmen -- Nomenklatur -- Enantiomere zeichnen -- Diastereomere -- meso-Verbindungen -- Fischer-Projektionen zeichnen -- Optische Aktivität -- Lösungen -- Stichwortverzeichnis -- End User License Agreement.
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  • 2
    Online Resource
    Online Resource
    Wiley-Schnellkurs Chemie. (2014)
    Newark :John Wiley & Sons, Incorporated,
    Details
    Keywords: Chemistry, Organic. ; Organic compounds -- Synthesis -- Problems, exercises, etc. ; Organic compounds -- Synthesis. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (630 pages)
    Edition: 2nd ed.
    ISBN: 9783527692507
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=2044718
    Language: German
    Note: Intro -- Einstiegstest -- Titel Seite -- Impressum -- Einleitung -- Kapitel 1: Zahlen und Einheiten -- Kapitel 2: Wie Sie Atome und Moleküle zählen -- Kapitel 3: Ausgeglichene Reaktionen und die Stöchiometrie von Gleichungen -- Kapitel 4: Das ideale Gasgesetz -- Kapitel 5: Energie und Enthalpie -- Kapitel 6: Orbitale, Bindungen und das Zählen von Elektronen -- Kapitel 7: Lewis-Formeln aufstellen -- Kapitel 8: Molekülgeometrie und Hybridisierungszustand -- Antworten -- Anhang -- Register -- End User License Agreement.
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  • 3
    Online Resource
    Online Resource
    Wiley-Schnellkurs Organische Chemie III : Synthese. (2022)
    Newark :John Wiley & Sons, Incorporated,
    Details
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (442 pages)
    Edition: 2nd ed.
    ISBN: 9783527839193
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6946283
    Language: German
    Note: Intro -- Titelblatt -- Impressum -- Inhaltsverzeichnis -- Einführung -- 1 Elektrophile Substitution am Aromaten (SEAr) -- Halogenierung und die Bedeutung der Lewis-Säuren -- Nitrierung -- Friedel-Crafts-Alkylierung und -Acylierung -- Sulfonierung -- Aktivierung und Desaktivierung -- Dirigierende Effekte -- Aktivierende und desaktivierende Substituenten erkennen -- Sterische Effekte vorhersagen und ausnutzen -- Synthesestrategien -- 2 Nucleophile Substitution am Aromaten (SNAr) -- Kriterien für die nucleophile Substitution am Aromaten -- Der SNAr-Mechanismus -- Eliminierungs-Additions-Mechanismus -- Strategischer Umgang mit Reaktionsmechanismen -- 3 Aldehyde und Ketone -- Synthese von Aldehyden und Ketonen -- Stabilität und Reaktivität von C=O-Bindungen -- H-Nucleophile -- O-Nucleophile -- S-Nucleophile -- N-Nucleophile -- C-Nucleophile -- Einige wichtige Ausnahmen von der Regel -- Wie man Fragen zur Syntheseplanung angeht -- 4 Carbonsäurederivate -- Reaktivität von Carbonsäurederivaten -- Allgemeingültige Regeln -- Säurehalogenide -- Säureanhydride -- Ester -- Amide und Nitrile -- Synthese-Planung -- 5 Enole und Enolate -- α-Protonen -- Reaktionen mit Enolen -- Synthese von Enolaten -- Haloform-Reaktion -- Alkylierung von Enolaten -- Aldol-Reaktionen -- Claisen-Kondensation -- Decarboxylierung -- Michael-Reaktionen -- 6 Amine -- Nucleophilie und Basizität von Aminen -- Synthese von Aminen durch SN2-Reaktionen -- Synthese von Aminen durch reduktive Aminierung -- Acylierung von Aminen -- Reaktionen von Aminen mit salpetriger Säure -- Aromatische Diazoniumsalze -- Antworten -- Index -- End User License Agreement.
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  • 4
    Online Resource
    Online Resource
    Wiley Schnellkurs Organische Chemie Grundlagen. (2014)
    Newark :John Wiley & Sons, Incorporated,
    Details
    Keywords: Organic photochemistry. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (468 pages)
    Edition: 1st ed.
    ISBN: 9783527689774
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=2028562
    Language: German
    Note: Intro -- Einstiegstest -- Lösungen des Eingangstests -- Titel -- Impressum -- Einführung -- Kapitel 1: Elektrophile Substitution am Aromaten (SEAr) -- Kapitel 2: Nucleophile Substitution am Aromaten (SNAr) -- Kapitel 3: Aldehyde und Ketone -- Kapitel 4: Carbonsäurederivate -- Kapitel 5: Enole und Enolate -- Kapitel 6: Amine -- Antworten -- Index.
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  • 5
    Online Resource
    Online Resource
    Wiley-Schnellkurs Organische Chemie II Reaktionen. (2021)
    Newark :John Wiley & Sons, Incorporated,
    Details
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (319 pages)
    Edition: 2nd ed.
    ISBN: 9783527835836
    Series Statement: Wiley Schnellkurs Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6579261
    Language: German
    Note: Intro -- Titelblatt -- Impressum -- Inhaltsverzeichnis -- Einführung -- Wie Sie dieses Buch benutzen können -- Wie Sie am besten lernen -- 1 Reaktionsmechanismen -- Geschwungene Pfeile -- Mit Pfeilen Elektronen verschieben -- Zwischenstufen zeichnen -- Nucleophile und Elektrophile -- Basen und Nucleophile -- Der Mechanismus bestimmt die Regiochemie -- Der Mechanismus bestimmt die Stereochemie -- Eine Liste von Reaktionsmechanismen -- 2 Substitutionsreaktionen -- Die Reaktionsmechanismen -- Faktor 1 - das Elektrophil (Substrat) -- Faktor 2 - das Nucleophil -- Faktor 3 - die Abgangsgruppe -- Faktor 4 - das Lösungsmittel -- Alle vier Faktoren verwenden -- Substitutionsreaktionen lehren uns wichtige Zusammenhänge -- 3 Eliminierungsreaktionen -- Der E2-Reaktionsmechanismus -- Einfluss der Regiochemie auf den Verlauf der E2-Reaktion -- Einfluss der Stereochemie auf den Verlauf der E2-Reaktion -- Der E1-Reaktionsmechanismus -- Einfluss der Regiochemie auf den Verlauf der E1-Reaktion -- Einfluss der Stereochemie auf den Verlauf der E1-Reaktion -- Substitution oder Eliminierung? -- Die Funktion des Reagenzes bestimmen -- Reaktionsmechanismen identifizieren -- Produkte vorherbestimmen -- 4 Additionsreaktionen -- Terminologie zur Beschreibung der Regiochemie -- Terminologie zur Beschreibung der Stereochemie -- H und H addieren -- H und X addieren, Markownikow -- H und Br addieren, Anti-Markownikow -- H und OH addieren, Markownikow -- H und OH addieren, Anti-Markownikow -- Synthesetechniken -- Br und Br addieren / Br und OH addieren -- OH und OH addieren, anti -- OH und OH addieren, syn -- Oxidative Alkenspaltung -- Zusammenfassung aller Reaktionen -- 5 Alkohole -- Alkohole benennen und kategorisieren -- Die Löslichkeit von Alkoholen bestimmen -- Die relative Acidität eines Alkohols abschätzen -- Alkohole herstellen: Eine Zusammenfassung. , Alkohole per Reduktion herstellen -- Alkohole mithilfe von Grignard-Reaktionen herstellen -- Methoden zur Herstellung von Alkoholen: eine Zusammenfassung -- Reaktionen mit Alkoholen: Substitution und Eliminierung -- Reaktionen mit Alkoholen: Oxidation -- Einen Alkohol zu einem Ether umsetzen -- 6 Synthese -- Ein-Schritt-Synthesen -- Mehrschritt-Synthesen -- Retrosynthese -- Eigene Aufgaben erstellen -- Lösungen -- Stichwortverzeichnis -- End User License Agreement.
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  • 6
    Electronic Resource
    Electronic Resource
    Calcium Potentiates Cyclic AMP Stimulation of Pineal Arylalkylamine N-Acetyltransferase (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 60 (1993), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Pineal arylalkylamine N-acetyltransferase (N-acetyltransferase) controls large daily changes in melatonin production. It is generally thought that the activity of this enzyme is controlled by norepinephrine acting exclusively via elevation of cyclic AMP. However, norepinephrine also elevates pineal intracellular Ca2+ concentration ([Ca2+]i), and it is not known whether Ca2+ is involved in regulating N-acetyltransferase activity other than through its established role in cyclic AMP production. In this study, the issue of whether Ca2+ enhances the effects of cyclic AMP on N-acetyltransferase activity was investigated. The effects of cyclic AMP protagonists (isobutylmethylxanthine, N6, 2′-O-dibutyryladenosine 3′,5′-cyclic monophosphate, 8-bromoadenosine 3′,5′-cyclic monophosphate, and adenosine 3′,5′-cyclic monophosphothioate, Sp-diastereomer) were examined in combination with [Ca2+]i protagonists (A23187, ionomycin, and phenylephrine). All [Ca2+]i protagonists potentiated the effects of cyclic AMP protagonists. For example, ionomycin potentiated the effects of low concentrations of 8-bromoadenosine 3′,5′-cyclic monophosphate, and A23187 potentiated the effects of isobutylmethylxanthine without altering cyclic AMP accumulation. These findings indicate that Ca2+ and cyclic AMP probably act physiologically in a coordinated manner to stimulate N-acetyltransferase activity; these second messengers could act directly at one or more sites or through indirect actions mediated by kinases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1993.tb03306.x
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  • 7
    Electronic Resource
    Electronic Resource
    Phosphatidylinositol Phosphodiesterase (Phospholipase C) Activity in the Pineal Gland: Characterization and Photoneural Regulation (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 48 (1987), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Phosphatidylinositol phosphodiesterase (PL-C) appears to be a key element in the adrenergic regulation of pineal cyclic AMP levels. In the present study, the rat pineal enzyme was characterized using exogenous [3H]phosphati-dylinositol (0.5 mM) as substrate. Half the enzyme activity was found in the cytosolic fraction, but the highest specific concentration was associated with the membrane fraction. Two pH optima (5.5 and 7.5) of enzyme activity were observed for the membrane fraction but only one in the cyto-sol fraction (pH 5.5). Enzyme activity in both fractions was Ca2+ dependent. In the case of the membrane protein in pH 7.5, the enzyme activity was sensitive to changes in Ca2+ in the 10–100 nAf range. Addition of an equimolar concentration of phosphatidylinositol 4-phosphate nearly completely inhibited the hydrolysis of [3H]phosphatidylinositol; other phospholipids (1.0 mM) were less potent. This may reflect our present finding that [3H]phosphatidylinositol 4-phosphate is a better substrate than [3H]phosphatidylinositol for the enzyme. Stimulus deprivation (2 weeks of constant light or superior cervical ganglionectomy) reduced the cytosolic activity by 30% and had no effect on the membrane-associated enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1987.tb05622.x
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  • 8
    Electronic Resource
    Electronic Resource
    Activators of Protein Kinase C Act at a Postreceptor Site to Amplify Cyclic AMP Production in Rat Pinealocytes (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 50 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Activation of α1-adrenoceptors appears to amplify β-adrenergic stimulation of cyclic AMP (CAMP) accumulation in rat pinealocytes severalfold by a mechanism involving activation of a Ca2+-, phospholipid-dependent protein kinase (protein kinase C). The mechanism of action of protein kinase C was investigated in this report using intact cells. Activation of protein kinase C with 4β-phorbol 12-myristate 13-acetate (PMA; 10−7M) or the α1-adrenergic agonist phenylephrine (PE; 10−6M) did not inhibit cAMP efflux in β-adrenergically stimulated cells. The amplification of the β-adrenergic cAMP response by these agents also occurred in the presence of isobutylmethylxanthine (10−3M) and Ro 20–1724 (104-M), an observation suggesting that inhibition of cAMP phosphodiesterase activity is not the mechanism of action. Furthermore, although PMA (107- M) caused a sixfold increase in the magnitude of the cAMP response to isoproterenol, it did not alter the EC50 of the response (1.7 × 10−8M), a result indicating that protein kinase C activation does not alter β-adrenoceptor sensitivity. The cAMP response following cholera toxin pretreatment (60–120 min) was rapidly and markedly enhanced by a,-adrenergic agonists (cirazoline 〉 PE 〉 methoxamine), by phorbol esters (PMA 〉 4β-phorbol 12,13,-dibutyrate 〉〉 4α-phorbol 12,13-didecanoate), and by synthetic diacylglycerols (1,2-dioctanoylglycerol 〉 1-oleoyl 2-acetylglycerol 〉〉 diolein). The cAMP response to forskolin (10−5M) was also increased by PE (3 × 10−6M) and PMA (10−7M). Together, these observations indicate that protein kinase C activation amplifies β-adrenergic stimulation of pinealocyte cAMP production at a site beyond the receptor, perhaps on a regulatory guanine nucleotide binding protein or adenylyl cyclase itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb13242.x
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  • 9
    Electronic Resource
    Electronic Resource
    Stimulus Deprivation Increases Pineal Gsα and Gβ (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 59 (1992), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Denervation and other forms of stimulus deprivation cause an increase in the magnitude of subsequent responses, a phenomenon commonly referred to as denervation supersensitivity. This has been well demonstrated with the cyclic AMP response to norepinephrine in the pineal gland. In the present report, we address the question of whether stimulus deprivation alters α and β subunits of the GTP binding regulatory protein that stimulates adenylyl cyclase activity (Gs). Stimulus deprivation of the pineal gland was produced by denervation (superior cervical ganglionectomy), decentralization of the superior cervical ganglia, or by exposure of the animal to continuous lighting. All increased both the α and β subunits of Gs (Gsα and Gβ) by up to fourfold, as estimated using semiquantitative western blot technology. These effects were detectable after 1 day of stimulus deprivation and were sustained for 2 weeks. The stimulatory effects of constant light-induced stimulus deprivation were also apparent by measuring cholera toxin-dependent ADP-ribosylation of Gsα, which revealed a fourfold increase in the amount of labeled substrate. The results of in vivo studies were confirmed with in vitro studies, which demonstrated a spontaneous increase in both Gsα and Gβ during 72 h of organ culture. The constant light-induced increases in both Gsα and Gβ were prevented by continuous administration of isoproterenol (0.3 mg/kg/day), supporting the suggestion that adrenergic stimulation controls the levels of Gsα and Gβ. These studies indicate that stimulus deprivation increases both Gsα and Gβ. It appears that such increases play a central role in generating supersensitivity in the pineal gland and may play a role in supersensitivity in other systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1992.tb08448.x
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  • 10
    Electronic Resource
    Electronic Resource
    A Simple and Rapid Method for the Purification of Ovine Pineal Arylalkylamine N-Acetyltransferase (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 48 (1987), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A two-step chromatographic procedure has been developed for the purification of ovine pineal arylalkylamine N-acetyltransferase (EC 2.3.1.87), based on the principles of disulfide exchange and anion exchange. The enzyme from 20 ovine pineal glands can be purified about 500-fold in a day; recovery is about 5%. Polyacrylamide gel electrophoretic analysis of the final preparation shows four major bands; one appears to be arylalkylamine N-acetyl-transferase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1987.tb04132.x
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