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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of peptidergic nerves in infantile hypertrophic pyloric stenosis (1990)
    Springer
    Pediatric surgery international 5 (1990), S. 110-113 
    Details
    ISSN: 1437-9813
    Keywords: Infantile hypertrophic pyloric stenosis ; Enkephalin ; Substance P ; Vasoactive intestinal polypeptide ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the recent literature it has been noted that peptidergic nerves may play an important role in infantile hypertrophic pyloric stenosis (HPS). Specimens from 20 patients with HPS were examined by immunohistochemistry with regard to the distribution of nerve cells and nerve fibers containing enkephalin (ENK), substance P (SP), and vasoactive intestinal polypeptide (VIP). Three subpopulations of peptides containing nerve cells and fibers were fairly numerous in the control specimens, but in the patients with HPS the density of the nerve fibers was markedly reduced and occasionally absent, especially the ENK- and VIP-containing fibers. In the myenteric plexus there was neither a reduction of nerve cell bodies nor of fibers. Our findings suggest that abnormalities of peptide-containing nerve fibers or impairment of neuronal function might results in HPS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178228
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Promoter switching during development and the termination site of the σ43 operon of Bacillus subtilis (1987)
    Springer
    Molecular genetics and genomics 207 (1987), S. 114-119 
    Details
    ISSN: 1617-4623
    Keywords: RNA polymerase ; Promoters ; Bacillus subtilis ; Sigma ; Transcription termination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Sequencing data indicated that the RNA polymerase (σ43) operon of Bacillus subtilis consisted of three genes, P23 (function unknown), dnaE (DNA primase), and rpoD (σ43) (Wang and Doi 1986a). S1 nuclease mapping experiments with RNA from various stages of growth demonstrated the presence of two overlapping σ43 promoters that controlled the expression of the operon during growth and a σ37 promoter that regulated the expression of the operon during the sporulation phase. This promoter switching mechanism ensured that this important operon would be expressed during different nutritional states of the cell and also illustrated a function for the minor RNA polymerase σ37 holoenzyme in the expression of genes which are normally expressed during the logarithmic phase of growth. The location of the transcription termination signal confirmed that the σ43 operon consists of three genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331498
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fluorescence behavior of porphinato zinc derivative in the molecular assembly of polymerized lipid (1989)
    Springer
    Polymer bulletin 21 (1989), S. 195-202 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary 3,8,13,17-Tetramethyl-7,12-dicarboxy-2,18-bis(octadecyloxycarbonylethyl) porphinato zinc (DCPZn) was incorporated into bilayer membrane of liposomes of 1,2-bis(2,4-octadecadienoyl)sn-glycero-3-phosphocholine (DODPC). The liposomes were polymerized by initiators like water-insoluble azobisisobutyronitrile (AIBN) or/and water-soluble azobis(amidinopropane) dihydrochloride (AAPD). DCPZn does not disturb the molecular packing of DODPC in the bilayer and after the polymerization, DCPZn is fixed monomolecularly in the network of the crosslinked bilayer membrane, while in the monomeric bilayers the dispersion state of DCPZn depends on temperature and concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266173
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chinese advancements in mathematics education (1992)
    Springer
    Educational studies in mathematics 23 (1992), S. 287-298 
    Details
    ISSN: 1573-0816
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This article describes the new development of mathematics education in the P.R. China. The paper explains changes which happened in the National Curriculum, teaching research, and the progress of our pupils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02309533
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  • 5
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    Estimating Phred scores of Illumina base calls by logistic regression and sparse modeling (2017)
    BioMed Central
    Details
    Publication Date: 2017-07-13
    Description: Phred quality scores are essential for downstream DNA analysis such as SNP detection and DNA assembly. Thus a valid model to define them is indispensable for any base-calling software. Recently, we developed t...
    Electronic ISSN: 1471-2105
    Topics: Biology , Computer Science
    Published by BioMed Central
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  • 6
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    Perindopril treatment promote left ventricle remodeling in patients with heart failure screened positive for autoantibodies against angiotensin II type 1 receptor (2013)
    BioMed Central
    Details
    Publication Date: 2013-11-01
    Description: Background: Autoantibodies specific to the angiotensin II type I receptor (anti-AT1-AR) have been implicated in the pathology of congestive heart failure (CHF). Anti-AT1-AR may be associated with left ventricular function in CHF patients treated with perindopril. Methods: Synthetic angiotensin II type 1 receptor (AT1-R) peptides served as the target antigen. An ELISA was used to screen the sera of 156 CHF patients, which were divided into positive and negative groups based on their anti-AT1-AR reactivity. Echocardiography and a 6-minute walk test were performed at baseline and after one year of perindopril therapy. The end-point events were compared over a 5-year follow-up. Results: Final analysis covered 138 patients, 82 positive and 56 negative. The frequency and geometric mean titre of anti-AT1-AR were significantly lower in the positive group after one year of treatment (all P 〈 0.01, from 100% to 73.2% and from 1:125.3 +/- 1.0 to 1:69.2 +/- 1.1). Of these, 22 patients showed no antibodies. Both groups showed improvement in left ventricular end-diastole, end-systolic dimensions, ejection fraction, and a 6-minute walk test by perindopril in combination with standard treatment regime for one year (all P 〈 0.01). However, the 82 patients positive for anti-AT1-AR showed more pronounced improvement than the 56 negative patients (all P 〈 0.05). However, after 5 years of follow-up, the rate of all causes and cardiovascular mortality attributable to any cause and the re-hospitalisation rate showed no significant differences between the two groups (all P 〉 0.05). Conclusions: Perindopril treatment significantly decreased the frequency and geometric mean titre in patients positive for anti-AT1-AR, even to complete ablation. These patients showed greater improvement in left ventricular remodeling and heart function than negative patients after one year of perindopril treatment in combination with standard treatment, but no significant differences in endpoint events were observed at 5 years. Anti-AT1-AR levels might be useful biomarkers of over-activation of the renin-angiotensin-aldosterone system for clinical medication.
    Electronic ISSN: 1471-2261
    Topics: Medicine
    Published by BioMed Central
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  • 7
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    Estimation of glomerular filtration rate by a radial basis function neural network in patients with type-2 diabetes mellitus (2013)
    BioMed Central
    Details
    Publication Date: 2013-08-30
    Description: Background: Accurate and precise estimates of glomerular filtration rate (GFR) are essential for clinical assessments, and many methods of estimation are available. We developed a radial basis function (RBF) network and assessed the performance of this method in the estimation of the GFRs of 207 patients with type-2 diabetes and CKD. Methods: Standard GFR (sGFR) was determined by 99mTc-DTPA renal dynamic imaging and GFR was also estimated by the 6-variable MDRD equation and the 4-variable MDRD equation. Results: Bland-Altmann analysis indicated that estimates from the RBF network were more precise than those from the other two methods for some groups of patients. However, the median difference of RBF network estimates from sGFR was greater than those from the other two estimates, indicating greater bias. For patients with stage I/II CKD, the median absolute difference of the RBF network estimate from sGFR was significantly lower, and the P50 of the RBF network estimate (n = 56, 87.5%) was significantly higher than that of the MDRD-4 estimate (n = 49, 76.6%) (p 〈 0.0167), indicating that the RBF network estimate provided greater accuracy for these patients. Conclusions: In patients with type-2 diabetes mellitus, estimation of GFR by our RBF network provided better precision and accuracy for some groups of patients than the estimation by the traditional MDRD equations. However, the RBF network estimates of GFR tended to have greater bias and higher than those indicated by sGFR determined by 99mTc-DTPA renal dynamic imaging.
    Electronic ISSN: 1471-2369
    Topics: Medicine
    Published by BioMed Central
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  • 8
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    Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation (2012)
    BioMed Central
    Details
    Publication Date: 2012-06-22
    Description: Background: Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes. The purpose of this study was to investigate whether intrathecal pretreatment with amitriptyline combined with post-injury intra-peritoneal amitriptyline is more effective than post-injury treatment alone on L5 spinal nerve ligation (SNL)-induced neuropathic pain. Methods: 96 adult male Sprague-Dawley rats were allocated into 4 groups: group S, Sham; group L, L5 spinal nerve Ligation with vehicle treatment; group A, SNL and post-injury intra-peritoneal (Abdominal) amitriptyline twice daily x 3 days; group P, intrathecal Pretreatment with amitriptyline, SNL and intra-peritoneal amitriptyline twice daily x 3 days. Responses to thermal and mechanical stimuli, as well as sodium channel expression in injured dorsal root ganglion (DRG) and activated glial cells in spinal dorsal horn (SDH) were measured pre-operatively and on post-operative day (POD) 4, 7, 14, 21 and 28. Results: SNL-evoked hyper-sensitivities responses to thermal and mechanical stimuli, up-regulated Nav1.3 and down-regulated Nav1.8 expression in DRG, and activated microglia and astrocytes in SDH. In group A, intra-peritoneal amitriptyline alone alleviated thermal hypersensitivity on POD7, reversed Nav1.8 and reduced activated microglia on POD14. In group P, intrathecal pretreatment with amitriptyline not only potentiated the effect of intra-peritoneal amitriptyline on thermal hypersensitivity and Nav1.8, but attenuated mechanical hypersensitivity on POD7 and reduced up-regulated Nav1.3 on POD14. Furthermore, this treatment regimen reduced astrocyte activation on POD14. Conclusions: Concomitant intrathecal pretreatment and post-injury intra-peritoneal amitriptyline was more effective than post-injury treatment alone on attenuation of behavioral hypersensitivity, decrease of activated microglia and astrocytes and dysregulated Nav1.3 and 1.8.
    Electronic ISSN: 1471-2377
    Topics: Medicine
    Published by BioMed Central
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  • 9
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    A robust and efficient statistical method for genetic association studies using case and control samples from multiple cohorts (2013)
    BioMed Central
    Details
    Publication Date: 2013-02-09
    Description: Background: The theoretical basis of genome-wide association studies (GWAS) is statistical inference of linkage disequilibrium (LD) between any polymorphic marker and a putative disease locus. Most methods widely implemented for such analyses are vulnerable to several key demographic factors and deliver a poor statistical power for detecting genuine associations and also a high false positive rate. Here, we present a likelihood-based statistical approach that accounts properly for non-random nature of case--control samples in regard of genotypic distribution at the loci in populations under study and confers flexibility to test for genetic association in presence of different confounding factors such as population structure, non-randomness of samples etc. Results: We implemented this novel method together with several popular methods in the literature of GWAS, to re-analyze recently published Parkinson's disease (PD) case--control samples. The real data analysis and computer simulation show that the new method confers not only significantly improved statistical power for detecting the associations but also robustness to the difficulties stemmed from non-randomly sampling and genetic structures when compared to its rivals. In particular, the new method detected 44 significant SNPs within 25 chromosomal regions of size 〈 1 Mb but only 6 SNPs in two of these regions were previously detected by the trend test based methods. It discovered two SNPs located 1.18 Mb and 0.18 Mb from the PD candidates, FGF20 and PARK8, without invoking false positive risk. Conclusions: We developed a novel likelihood-based method which provides adequate estimation of LD and other population model parameters by using case and control samples, the ease in integration of these samples from multiple genetically divergent populations and thus confers statistically robust and powerful analyses of GWAS. On basis of simulation studies and analysis of real datasets, we demonstrated significant improvement of the new method over the non-parametric trend test, which is the most popularly implemented in the literature of GWAS.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 10
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    Prevalence of prior HIV testing and associated factors among MSM in Zhejiang Province, China: a cross-sectional study (2016)
    BioMed Central
    Details
    Publication Date: 2016-11-12
    Description: Men who have sex with men (MSM) have become one of high-risk population for human immunodeficiency virus (HIV) infection, due to their multiple sex partners and unprotected anal intercourse. Promoting HIV test...
    Electronic ISSN: 1471-2458
    Topics: Medicine
    Published by BioMed Central
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