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  • 1
    Electronic Resource
    Electronic Resource
    Structure of an unusual, 8-coordinate, exclusive cryptate of ytterbium(III) containing multiple nitrato andN-thiocyanato ligands (1994)
    Springer
    Journal of chemical crystallography 24 (1994), S. 577-580 
    Details
    ISSN: 1572-8854
    Keywords: 8-Coordinate cryptate ; ytterbium(III) ; rare-earth elements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The first example of an 8-coordinate cryptate of cryptand(2,2,2) [N(CH2CH2OCH2CH2OCH2CH2)3N], Yb3+, and multiple nitrato andN-thiocyanato ligands, H2Yb(NCS)3(NO3)2(2,2,2)·H2O (I), has been synthesized. The crystal and molecular structure ofI have been determined by single-crystal X-ray diffraction. The Yb3+ cation is not located in the cavity of the cryptand(2,2,2), but is connected to it through a water bridge by two hydrogen bonds to form an exclusive cryptate. The two H+ ions are mostly probably bound to the two N atoms of cryptand(2,2,2). The coordinating atoms of the NO 3 − , NCS−, and H2O ligands constitute a trigonododecahedron around the central Yb3+ ion. CryptateI crystallizes in the monoclinic space groupP2l/n withZ=4. The finalR factor for 3659 independent reflections, following correction for Lorentz and polarization effects and havingF 0〉5σ(F 0), is 0.053. Infrared spectroscopic data for1 are consistent with the X-ray crystal structure results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01671669
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  • 2
    Electronic Resource
    Electronic Resource
    Analogous copper(I) coordination in metallothionein from yeast and the separate domains of the mammalian protein (1992)
    Springer
    BioMetals 5 (1992), S. 187-191 
    Details
    ISSN: 1572-8773
    Keywords: circular dichroism ; copper-thiolate cluster ; fluorescence ; metallothionein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The three-dimensional structures of both vertebrate Cu12-metallothionein (class 1) and yeast Cu8-thionein (class 2) are still unknown. The different copper:protein stoichiometry compared with that of the (ZnCd)7-metallothioneins was expected to alter the metal-thiolate cluster structure considerably. In order to avoid possible domain interactions in the hepatic rat metallothionein, separate chemically synthesized α-and β-domains were used rather than the apoprotein. Apo yeast thionein, and the α-and β-domains of rat liver metallothionein-2 were reconstituted by Cu(I) titration. Reconstitution steps were monitored using spectroscopic methods including luminescence emission and circular dichroism. Upon UV irradiation a linear increase in intensity of the orange-red luminescence was observed near 600 nm up to 6 Cu eq using either compound regardless of the different cysteine sulfur content (yeast thionein 12S, α-domain 11S, β-domain 9S). The characteristic dichroic properties of the yeast copper-protein between 240 and 400 nm were in good agreement with those of the respective class 1 metallothionein domains. All observed Cotton bands were of similar shape and appeared in the same wavelength regions. However, the molar ellipticities were less pronounced in the α-and β-fragments employed. There appears to be a striking similarity between the oligonuclear Cu(I) binding centers in all metallothionein species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061327
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  • 3
    Electronic Resource
    Electronic Resource
    Letter to the Editor: 1H, 13C and 15N resonance assignments of Aquifex aeolicus shikimate kinase in complex with the substrate shikimate (2000)
    Springer
    Journal of biomolecular NMR 17 (2000), S. 277-278 
    Details
    ISSN: 1573-5001
    Keywords: resonance assignment ; shikimate ; shikimate kinase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008322130148
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  • 4
    Electronic Resource
    Electronic Resource
    Geochemical mass balances of major chemical constituents in the watershed of the Changhuajian River in China (1995)
    Springer
    Aquatic geochemistry 1 (1995), S. 147-156 
    Details
    ISSN: 1573-1421
    Keywords: geochemistry ; mass balance ; chemical weathering ; mechanical denudation ; Changhuajiang River watershed
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences
    Notes: Abstract Based on the geological background, R-mode factor statistics, and the analysis of the stability diagram for the corresponding system, five weathering reactions controlling the surface-water chemical composition in the watershed of the Changhuajiang River are deduced. In the mass balance model, the precipitation accounts for some solute input, since the rainwater is dilute without pollution. Most of the Ca2+ and HCO 3 − ions are from the dissolution of calcite, K+, Na+, H4SiO4 and some of the Mg2+ and HCO 3 − come from albite and biotite weathering to kaolinite. The dissolution of dolomite and gypsum controls the mass balances of Mg2+ and SO 4 2− . The dissolution of calcite is the dominant chemical weathering reaction in the watershed because of its reactivity and high concentration. In the watershed in 1986, the chemical weathering rate was 0.073 (kg/m2 a), and the mechanical denudation rate is 0.093 (kg/m2 a). The chemical weathering mass output proportion of carbonate rocks to silicate rocks was about three to one.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00702888
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  • 5
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    NQO1 protein expression predicts poor prognosis of non-small cell lung cancers (2015)
    BioMed Central
    Details
    Publication Date: 2015-04-01
    Description: Background: High-level expression of NAD(P)H: quinoneoxidoreductase 1 (NQO1) has been correlated with many types of human cancers, suggesting that NQO1 plays important roles in tumor occurrence and progression. This study attempted to explore the role of NQO1 in tumor progression and prognostic evaluation of non-small cell lung cancer (NSCLC). Methods: Total 164 tissue samples, including 150 NSCLC paired with the adjacent non-tumor tissues and 14 normal lung tissues, were picked-up for immunohistochemical (IHC) staining of the NQO1 protein, and immunofluorescence (IF) staining was also performed to detect the subcellular localization of the NQO1 protein in A549 human lung cancer cells. The correlation between NQO1 expression and clinicopathological characteristics were evaluated by Chi-square test and Fisher’s exact tests. The disease-free survival (DFS) and overall survival (OS) rates of NSCLC patients were calculated by the Kaplan-Meier method, and univariate and multivariate analyses were performed using the Cox proportional hazards regression model. Results: The NQO1 protein showed a mainly cytoplasmic staining pattern in lung cancer cells, including adenocarcinoma and squamous cell carcinoma (SCC). Both positive rate and strongly positive rate of NQO1 protein expression were significantly higher in NSCLC (59.3% and 28.0%) than that in adjacent non tumor (8.0% and 1.3%) and normal lung tissues (0%). The positive rate of NQO1 was related with clinical stage and lymph node metastasis, and the strongly positive rate of NQO1 protein was significantly correlated with tumor size, poor differentiation, advanced clinical stage and lymph node metastasis in NSCLC. Additionally, survival analyses showed that the patients with NQO1 positive expression had lower OS rates compared with those with NQO1 negative expression in the groups of T1-2, T3-4, without LN metastasis and stage I-II of NSCLC, respectively; however, in the groups of patients with LN metastasis or III-IV stages, OS rate was not correlated with NQO1 expression status. Moreover, multivariate analysis suggested that NQO1 emerged as a significant independent prognostic factor along with tumor size, differentiation, lymph node metastasis and clinical stage in patients with NSCLC. Conclusions: NQO1 is upregulated in NSCLC, and it may be a useful poor prognostic biomarker and a potential therapeutic target for patients with NSCLC.
    Electronic ISSN: 1471-2407
    Topics: Medicine
    Published by BioMed Central
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  • 6
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    Highly diversified fungi are associated with the achlorophyllous orchid Gastrodia flavilabella (2015)
    BioMed Central
    Details
    Publication Date: 2015-03-16
    Description: Background: Mycoheterotrophic orchids are achlorophyllous plants that obtain carbon and nutrients from their mycorrhizal fungi. They often show strong preferential association with certain fungi and may obtain nutrients from surrounding photosynthetic plants through ectomycorrhizal fungi. Gastrodia is a large genus of mycoheterotrophic orchids in Asia, but Gastrodia species’ association with fungi has not been well studied. We asked two questions: (1) whether certain fungi were preferentially associated with G. flavilabella, which is an orchid in Taiwan and (2) whether fungal associations of G. flavilabella were affected by the composition of fungi in the environment. Results: Using next-generation sequencing, we studied the fungal communities in the tubers of Gastrodia flavilabella and the surrounding soil. We found (1) highly diversified fungi in the G. flavilabella tubers, (2) that Mycena species were the predominant fungi in the tubers but minor in the surrounding soil, and (3) the fungal communities in the G. flavilabella tubers were clearly distinct from those in the surrounding soil. We also found that the fungal composition in soil can change quickly with distance. Conclusions: G. flavilabella was associated with many more fungi than previously thought. Among the fungi in the tuber of G. flavilabella, Mycena species were predominant, different from the previous finding that adult G. elata depends on Armillaria species for nutritional supply. Moreover, the preferential fungus association of G. flavilabella was not significantly influenced by the composition of fungi in the environment.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 7
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    Recurrent acute coronary syndrome and restenosis after percutaneous coronary intervention in a patient with idiopathic thrombocytopenic purpura: a case report and literature review (2015)
    BioMed Central
    Details
    Publication Date: 2015-09-19
    Description: Background: Platelets play a pivotal role in the pathogenesis of acute coronary syndrome (ACS) and acute and chronic complications following percutaneous coronary intervention (PCI). Platelet inhibition is a cornerstone in the management of these patients. Idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder characterized by premature platelet destruction mediated by autoantibodies. The safety of antiplatelet therapy and PCI in patients who have ACS and ITP is unknown. The aim of the present study is to discuss the management strategies for patients who have ACS and ITP and to review limited data available in the literature.Case presentationWe report the case of a patient with ITP who underwent three separate coronary interventions. The first PCI with stenting was performed in the left anterior descending artery 5 years ago while the patient suffered an anterior acute myocardial infarction, and the platelet count at admission was 90 × 10 9 /L. The patient presented with recurrent ACS and severe in-stent restenosis 5 years after the first PCI, and the platelet count at admission was 18 × 10 9 /L, and elevated to 87 × 10 9 /L after platelets transfusion. He was treated successfully with cutting balloon angioplasty under anticoagulation with unfractionated heparin and antiagregation with acetylsalicylic acid and clopidogrel. Four months later after cutting balloon angioplasty, the patient received an intracoronary stent when he once again presented with recurrent ACS in the setting of restenosis. The patient has been observed for 1.5 years without restenosis after the third PCI. Conclusion: We reviewed all the cases in the literature involving PCI and discussed the management strategies in patients with ITP and ACS. Available data suggest that PCI can be safe and feasible, and the risk–benefit equation of PCI procedures and antiplatelet therapies should be carefully evaluated, and the treatment should be individualized.
    Electronic ISSN: 1471-2261
    Topics: Medicine
    Published by BioMed Central
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  • 8
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    Studying the therapeutic effects of hemoperfusion with continuous venovenous hemofiltration in paraquat-poisoned patients by the ratio of residual normal lung in 3D-CT image (2016)
    BioMed Central
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    Publication Date: 2016-02-17
    Electronic ISSN: 1471-227X
    Topics: Medicine
    Published by BioMed Central
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  • 9
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    Antibacterial constituents of Fructus Chebulae Immaturus and their mechanisms of action (2016)
    BioMed Central
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    Publication Date: 2016-07-03
    Description: To extract, purify, and identify the effective constituents of aqueous extract of Fructus Chebulae Immaturus, and analyze the bactericidal effects of total tannins.
    Electronic ISSN: 1472-6882
    Topics: Medicine
    Published by BioMed Central
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  • 10
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    Large-scale phosphoproteome analysis in seedling leaves of Brachypodium distachyon L. (2014)
    BioMed Central
    Details
    Publication Date: 2014-05-17
    Description: Background: Protein phosphorylation is one of the most important post-translational modifications involved in the regulation of plant growth and development as well as diverse stress response. As a member of the Poaceae, Brachypodium distachyon L. is a new model plant for wheat and barley as well as several potential biofuel grasses such as switchgrass. Vegetative growth is vital for biomass accumulation of plants, but knowledge regarding the role of protein phosphorylation modification during vegetative growth, especially in biofuel plants, is far from comprehensive. Results: In this study, we carried out the first large-scale phosphoproteome analysis of seedling leaves in Brachypodium accession Bd21 using TiO2 microcolumns combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) and MaxQuant software. A total of 1470 phosphorylation sites in 950 phosphoproteins were identified, and these phosphoproteins were implicated in various molecular functions and basic cellular processes by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Among the 950 phosphoproteins identified, 127 contained 3 to 8 phosphorylation sites. Conservation analysis showed that 93.4% of the 950 phosphoproteins had phosphorylation orthologs in other plant species. Motif-X analysis of the phosphorylation sites identified 13 significantly enriched phosphorylation motifs, of which 3 were novel phosphorylation motifs. Meanwhile, there were 91 phosphoproteins with both multiple phosphorylation sites and multiple phosphorylation motifs. In addition, we identified 58 phosphorylated transcription factors across 21 families and found out 6 significantly over-represented transcription factor families (C3H, Trihelix, CAMTA, TALE, MYB_related and CPP). Eighty-four protein kinases (PKs), 8 protein phosphatases (PPs) and 6 CESAs were recognized as phosphoproteins. Conclusions: Through a large-scale bioinformatics analysis of the phosphorylation data in seedling leaves, a complicated PKs- and PPs- centered network related to rapid vegetative growth was deciphered in B. distachyon. We revealed a MAPK cascade network that might play the crucial roles during the phosphorylation signal transduction in leaf growth and development. The phosphoproteins and phosphosites identified from our study expanded our knowledge of protein phosphorylation modification in plants, especially in monocots.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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