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  • Springer  (11)
  • Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik Leibniz-Institut im Forschungsverbund Berlin e.V.  (1)
  • 1
    Online Resource
    Online Resource
    Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik Leibniz-Institut im Forschungsverbund Berlin e.V.
    Keywords: Forschungsbericht
    Description / Table of Contents: We prove a conditional stability estimate of log-type for determining unknown boundaries from a single Cauchy data taken on an accessible subboundary. Our approach relies on new interior and boundary estimates derived from the Carleman estimate for elliptic equations. A local stability result for target identification of an acoustic sound-soft scatterer from a single far-field pattern is also obtained.
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (25 Seiten, 443 kB)
    Series Statement: Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik no. 2351
    Language: English
    Note: Literaturverzeichnis: Seite 22-23
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  • 2
    ISSN: 1436-2813
    Keywords: glucagonoma ; protein kinase C ; immunoelectron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this report, we briefly present the case of a 67-year-old woman who developed recurrent glucagonoma with lymph node metastasis. An immunohistochemical study of the metastatic tumor revealed immunoreactivity of glucagon and protein kinase C (PKC)-α, -β, and -γ in the tumor cells, two types of which were seen by electron microscopy. One type had abundant secretory granules and mitochondria, while the other had few granules and mitochondria. Some granules were similar to typical A cell granules and others were atypical. An immunoelectron microscopic demonstration revealed PKC-α, -β, and -γ immunostaining in the cytoplasm of all the tumor cells, while some secretory granules had PKC immunostaining, and others had no immunostaining. Thus, it appears that metastatic glucagonoma and its associated granules are composed of two types of mature and immature cells or granules. As immunoreactivity of PKC-α and -γ was found in the tumor cells, but not in the normal A cells of the islets of Langerhans, the PKC subspecies α and γ, which are not present in normal pancreatic A cells, may exist in human glucagonoma cells.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 19 (1995), S. 758-763 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nous avons évalué la choléystectomie étendue, c'est à dire combinée à une résection en coin du lit vésiculaire et une lymphadénectomie régionale, pour cancer de la vésicule biliaire. Entre 1971 et 1993, 227 cas de cancer de la vésicule ont été traités. Parmi ceux-ci, 59 ont eu une simple cholécystectomie et 66 ont eu une choléystectomie «étendue». Les tumeurs ont été classées par la Société Japonaise de la Chirurgie Biliaire. Dans les stades I et II, l'évolution après la chlécystectomie étendue a été meilleure qu'après la cholécystectomie simple. La survie cumulative à 5 ans a été, respectivement dans les stades I, II, III et IV, de 78.9%, 63.6%, 44.4%, et 8.3. La survie chez les patients stade I est excellente. Dans les stades II, III, et IV, S3, N2, Hinf1 et Binf1, le pronostic est nettement moins bon. C'est dans ces cas qu'une chirurgie plus agressive est indiquée.
    Abstract: Resumen Hemos estudiado el procedimiento de colecistectomía ampliada, resección en cuña del lecho vesicular y linfadenectomía regional en el tratamiento del carcinoma de la vesícula biliar. En el período 1971 a 1993, se trataron 227 casos, de los cuales 59 fueron sometidos a colecistectomía simple y 66 al procedimiento ampliado. Los tumores fueron clasificados de acuerdo con la estadificación propuesta por la Sociedad Japonesa de Cirugía Biliar. En los estados I y II, la colecistectomía ampliada demostró un mejor resultado que la colecistectomía simple. En los casos de colecistectomía ampliada, la tasa acumulada de sobrevida a 5 años fue 78.9% en el estado I, 63.6% en el estado II, 44.4% en el estado III y 8.3% en el estado IV. La tasa de sobrevida en el estado I fue excelente. En los casos con tumores más avanzados que el estado II, S3 N2 Hinf1 y Binf1, el pronóstico fue significativamente peor. En estos casos puede ser necesaria una conducta quirúrgica más agresiva.
    Notes: Abstract We evaluated extended cholecystectomy, wedge resection of the gallbladder bed, and regional lymphadenectomy for carcinoma of the gallbladder. Between 1971 and 1993 we treated 227 patients, 59 of whom were treated with simple cholecystectomy and 66 with extended cholecystectomy. The tumors were classified according to the stages proposed by the Japanese Society of Biliary Surgery. For Stage I and II discase extended cholecystectomy had a better result than simple cholecystectomy. For the extended cholecystectomy cases the cumulative 5-year survival rate was 78.9% for Stage I, 63.6% for Stage II, 44.4% for Stage III, and 8.3% for Stage IV. The survival of Stage I patients was excellent. For cases more advanced than Stage II (S3, N2, Hinf1, and Binf1), the prognosis was significantly worse. In these cases more aggressive surgery may be needed.
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  • 4
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. To diagnose early gallbladder carcinoma is difficult but essential to improve the survival of the patients with this cancer. Fifty-three early gallbladder cancers were macroscopically divided into protruding and flat types. The diagnostic devises [ultrasonography (US), computed tomography (CT), and drip infusion cholangiography (DIC)] were compared for their ability of early detection. The specimens were examined cytologically for diagnosis during operation and the p53 protein was investigated. Thirty-three cases were of the protruding type, eighteen of the flat type, and two unclassified. Carcinoma tended to be missed when gallstones were present. Preoperative diagnosis of the flat type was difficult. Tumor location did not always correlate with the preoperative diagnosis. Of the misdiagnosed cases of the protruding type, half were missed with US and CT and were not visualized clearly by DIC. Among the flat type cancers, only three had no abnormal findings by diagnostic imaging. Cytologic examination was effective, and p53 was expressed only in early carcinoma, not in adenoma or dysplasia. Even in the presence of gallstones or cholecystitis, any abnormal findings should make one suspicious of gallbladder cancer. Cytology and p53 expression may be useful for the intraoperative diagnosis, and a combination of diagnostic methods is important.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1436-2813
    Keywords: experimental cholesterol gallstone ; ileectomy ; biliary and fecal bile acids ; bile acid pool size ; plasma and liver cholesterol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract After a lithogenic diet containing 0.5 per cent cholesterol and 0.25 per cent sodium cholate was fed to a group of normal Crj-ICR male mice for 10 days, cholesterol gallstones developed. No formation of gallstones occurred, however, in a group of mice from which 20 cms of terminal ileum had been removed prior to the feeding of the lithogenic diet. The biliary concentrations of cholesterol, phospholipids and bile acids were markedly lower in the ileectomized mice, with the decrease in cholesterol concentration being most significant. On the other hand, fecal excretion of sterols and bile acids increased in the ileectomized mice. The pool size of bile acids increased after the feeding of the lithogenic diet, but ileectomy decreased the pool size in mice fed the ordinary or lithogenic diets. The biliary concentration of cholic acid increased after the feeding of the lithogenic diet, but decreased with ileectomy. The biliary concentration and fecal excretion of deoxycholic acid markedly increased, while those of β-muricholic acid and its secondary bile acids, ω-muricholic acid and hyodeoxycholic acid, decreased. The increase in plasma and liver cholesterol levels after the feeding of the lithogenic diet was prevented by ileectomy. These data suggest that ileectomy prevents the formation of cholesterol gallstones after the feeding of a lithogenic diet due to a decrease in cholic acid absorption.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A new mutant α-1-antichymotrypsin (variant ACT) was found by polymerase chain reaction single strand conformation polymorphism and direct sequencing. In this variant ACT, two bases (AA) were deleted from codon 391. This resulted in a different amino acid sequence downstream of the deletion point, elongating the peptide chain by 10 amino acids.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Herpes simplex virus type 2 (HSV-2), strain YS-4 C-1, isolated by plaque cloning from a clinical isolate was found to be resistant to acyclovir (ACV; acycloguanosine) in vitro. It was sensitive to phosphonoacetic acid and 9-β-D-arabinofuranosyladenine. Thymidine kinase (TK) activity of YS-4 C-1 was less than 1% of that of other strains from the same clinical source. However, thymidine plaque autoradiography showed that YS-4 C-1 was not completely deficient in TK activity. YS-4 C-1 showed high virulence for mice like other HSV-2 strains which were sensitive to ACV. YS-4 C-1 was able to establish latent infection in mice. Virus isolated from the brain of a mouse died after being inoculated with YS-4 C-1 was also resistant to ACV. ACV was not effective in mice inoculated with YS-4 C-1. This study shows that not all ACV-resistant strains are avirulent for mice.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-5922
    Keywords: acute pancreatitis ; hepatocyte growth factor ; cytokine ; severity ; organ failure ; prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum levels of hepatocyte growth factor (HGF), C-reactive protein (CRP), and interleukin-6 (IL-6) were determined at the time of admission in 38 patients with acute pancreatitis. The clinical utility of HGF for the detection of severe pancreatitis and for predicting prognosis, bacterial infection (infected pancreatic necrosis or sepsis), and organ dysfunction (liver, kidney, and lung) during the clinical course of acute pancreatitis was compared with the clinical utility of CRP and IL-6 by analysis of receiver operator characteristic (ROC) curves. The optimum cutoff levels of HGF for severity, prognosis, infection, hepatic dysfunction, renal dysfunction, and respiratory dysfunction were 0.9, 1.1, 1.0, 1.1, 1.1, and 1.0ng/ml, respectively. HGF was as useful as CRP and more useful than IL-6 for detection of severe pancreatitis and for predicting hepatic dysfunction. Moreover, HGF was more useful than CRP or IL-6 for predicting prognosis, renal dysfunction, and respiratory dysfunction. However, for predicting infection, CRP was more useful than HGF. These results suggest that serum HGF levels on admission may be a useful new clinical parameter for determining the prognosis of acute pancreatitis and that HGF may be closely related to the organ dysfunction of acute pancreatitis.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of hepato-biliary-pancreatic surgery 3 (1996), S. 203-209 
    ISSN: 1436-0691
    Keywords: acute pancreatitis ; national survey ; clinical criteria of severity ; intensive care ; surgical treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The status of severe acute pancreatitis in Japan has been clarified by a series of surveys of the disease carried out by the Research Committee of Intractable Diseases of the Pancreas under the aegis of the Japanese Ministry of Health and Welfare. The severity of disease classification systems, consisting of: clinical signs and symptoms, laboratory data, and computed tomographic grading, have led to early detection of severe disease with precise assessment and the potential to screen for local complications. Early mortality has been markedly reduced by intensive care, with specific treatment modalities, while there has been an increase in late mortality caused by severe infection. Indications for surgery have been changed: to debridement for infected pancreatic necrosis and drainage of abscess although the timing of surgery is still controversial.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1436-0691
    Keywords: Key words: agenesis ; pancreatic anomaly ; MRCP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Pancreatic anomalies are occasionally reported, but complete agenesis of the dorsal pancreas is extremely rare. We report a 47-year-old woman with complete agenesis of the dorsal pancreas. This patient initially presented with jaundice. Computed tomography did not reveal the pancreatic corpus or tail. Endoscopic retrograde cholangiopancreatography and magnetic resonance cholangiopancreatography did not visualize the dorsal pancreatic duct. Choledochojejunostomy was performed because she had obstructive jaundice. At laparotomy, there was an enlarged pancreatic head, but no distal pancreas was seen. Histological examination of the pancreatic biopsy specimen showed scattered islets of Langerhans in diffuse fibrosis, with destruction of the glandular parenchyma. This case was diagnosed as complete agenesis of the dorsal pancreas.
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