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  • BioMed Central  (15)
  • Berlin : NOW GmbH - Nationale Organisation Wasserstoff- und Brennstoffzellentechnologie
  • Bonn : Bundesinstitut für Bau-, Stadt- und Raumforschung (BBSR) im Bundesamt für Bauwesen und Raumordnung (BBR)
  • 1
    Online Resource
    Online Resource
    Lowtech im Gebäudebereich : Fachsymposium TU Berlin 16.05.2022 (2023)
    Bonn : Bundesinstitut für Bau-, Stadt- und Raumforschung (BBSR) im Bundesamt für Bauwesen und Raumordnung (BBR)
    Details Availability
    Keywords: Konferenzschrift ; Forschungsbericht ; Konferenzschrift 20230824 2022 ; Deutschland ; Klimagerechtes Bauen ; Energieeffizienz ; Haustechnik
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (116 Seiten, 5,64 MB) , Illustrationen, Diagramme
    Edition: Stand März 2023
    ISBN: 9783879940981
    Series Statement: Schriftenreihe Zukunft Bauen: Forschung für die Praxis Band 32
    URL: https://www.bbsr.bund.de/BBSR/DE/veroeffentlichungen/zukunft-bauen-fp/2023/band-32-dl.pdf?__blob=publicationFile&v=2
    URL: https://edocs.tib.eu/files/e01fn23/1858255953.pdf
    URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023082310021056985731
    URL: https://d-nb.info/1299944213/34
    URN: urn:nbn:de:101:1-2023082310021056985731
    DDC: 693.832
    RVK:
    ZH 3000
    Language: German
    Note: Literaturangaben , Dieses Projekt wurde gefördert vom Bundesinstitut für Bau-, Stadt- und Raumforschung (BBSR) im Auftrag des Bundesministeriums für Wohnen, Stadtentwicklung und Bauwesen (BMWSB) aus Mitteln des Innovationsprogramms Zukunft Bau , Projektlaufzeit: 01.2022 bis 06.2022
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  • 2
    Online Resource
    Online Resource
    Hybrid- und Elektrobus-Projekte in Deutschland : Statusbericht 2015/16 : Arbeitsgruppe Innovative Antriebe Bus : erneuerbar mobil (2016)
    Berlin : NOW GmbH - Nationale Organisation Wasserstoff- und Brennstoffzellentechnologie
    Details Availability
    Keywords: Busverkehr ; Elektrofahrzeug ; Hybridfahrzeug ; Deutschland ; Arbeitsgruppe Innovative Antriebe Bus ; Batteriebus ; Dieselhybrid ; ÖPNV ; Elektrobus ; Elektro-Bus ; Graue Literatur ; Amtsdruckschrift ; Forschungsbericht ; Omnibus ; Elektrofahrzeug ; Hybridfahrzeug
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (70 Seiten, 4,91 MB) , Illustrationen, Diagramme, Karte
    Series Statement: Modellregionen Elektromobilität
    URL: https://edocs.tib.eu/files/e01fn16/871337282.pdf
    Language: German
    Note: Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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  • 3
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    The Perioperative Surgical Home: how can it make the case so everyone wins? (2013)
    BioMed Central
    Details
    Publication Date: 2013-03-16
    Description: Background: Varied and fragmented care plans undertaken by different practitioners currently expose surgical patients to lapses in expected care, increase the chance for operational mistakes and accidents, and often result in unnecessary care. The Perioperative Surgical Home has thus been proposed by the American Society of Anesthesiologists and other stakeholders as an innovative, patient-centered, surgical continuity of care model that incorporates shared decision making. Topics central to the debate about an anesthesiology-based Perioperative Surgical Home include: holding the gains made in anesthesia-related patient safety; impacting surgical morbidity and mortality, including failure-to-rescue; achieving healthcare outcome metrics; assimilating comparative effectiveness research into the model; establishing necessary audit and data collection; a comparison with the hospitalist model of perioperative care; the perspective of the surgeon; the benefits of the Perioperative Surgical Home to the specialty of anesthesiology; and its associated healthcare economic advantages.DiscussionImproving surgical morbidity and mortality mandates a more comprehensive and integrated approach to the management of surgical patients. In their expanded capacity as the surgical patient's "perioperativist," anesthesiologists can play a key role in compliance with broader set of process measures, thus becoming a more vital and valuable provider from the patient, administrator, and payer perspective. The robust perioperative databases created within the Perioperative Surgical Home present new opportunities for health services and population-level research. The Perioperative Surgical Home is not intended to replace the surgeon's patient care responsibility, but rather leverage the abilities of the entire perioperative care team in the service of the patient. To achieve this goal, it will be necessary to expand the core knowledge, skills, and experience of anesthesiologists. Anesthesiologists will need to view becoming perioperative physicians as an expansion of the specialty, rather than an abdication of their traditional intraoperative role. The Perioperative Surgical Home will need to create strategic added value for a health system and payers. This added value will strengthen the position of anesthesiologists as they navigate and negotiate in the face of finite, if not decreasing fiscal resources.SummaryBroadening the anesthesiologist's scope of practice via the Perioperative Surgical Home may promote standardization and improve clinical outcomes and decrease resource utilization by providing greater patient-centered continuity of care throughout the preoperative, intraoperative, and postoperative periods.
    Electronic ISSN: 1471-2253
    Topics: Medicine
    Published by BioMed Central
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  • 4
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    Impact of naturally occurring amino acid variations on the detection of HIV-1 p24 in diagnostic antigen tests (2015)
    BioMed Central
    Details
    Publication Date: 2015-10-30
    Description: Background: The detection of HIV-1 p24 antigen in diagnostic tests relies on antibodies binding to conserved areas of the protein to cover the full range of HIV-1 subtypes. Using a panel of 43 different virus-like particles (VLPs) expressing Gag from clinical HIV-1 isolates, we previously found that some highly sensitive tests completely failed to detect p24 of certain VLPs, seemingly unrelated to their subtype. Here we aimed to investigate the reason for this failure, hypothesising that it might be due to single amino acid variations in conserved epitopes. Methods: Using amino acid alignment, we identified single amino acid variations at position 16 or 170 of p24, unique to those VLPs that failed to be detected in certain diagnostic tests. Through DNA-mutagenesis, these amino acids were changed to ones more commonly found at these positions. The impact of these changes on p24 detection was tested in commercial diagnostic tests as well as by Western Blot and ELISA, using epitope-specific antibodies.Results and ConclusionsChanging positions 16 or 170 to consensus amino acids restored the detection of p24 by the investigated diagnostic tests as well as by epitope-specific antibodies in Western Blot and ELISA. Hence, single amino acid changes in conserved epitopes can lead to the failure of p24 detection and thus to false-negative results. To optimise HIV diagnostic tests, they should also be evaluated using isolates which harbour less-frequent epitope variants.
    Electronic ISSN: 1471-2334
    Topics: Medicine
    Published by BioMed Central
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  • 5
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    Preoperative management of antiplatelet drugs for a coronary artery stent: how can we hit a moving target? (2014)
    BioMed Central
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    Publication Date: 2014-08-24
    Description: Background: With the advent of percutaneous coronary intervention, specifically the bare metal stent and subsequently, the drug-eluting stent, the scope of interventional cardiology has greatly increased. Aspirin, in combination with a thienopyridine is the present-day cornerstone of oral antiplatelet therapy after coronary artery stent placement. Continuing this chronic antiplatelet therapy, to mitigate a perioperative major adverse cardiac event, can be challenging and remains controversial in patients with a coronary artery stent undergoing non-cardiac surgery. We describe here the rationale for and successful use of an alternate approach to formulating local institutional management protocols for patients with a coronary artery stent, undergoing an elective surgical procedure.DiscussionA recent systematic review identified 11 clinical practice guidelines for the perioperative management of antiplatelet therapy in patients with a coronary stent who need non-cardiac surgery. However, there is significant variance and inadequacy with these current applicable professional society guidelines. Moreover, persistently variable success has been experienced in translating even well-grounded national clinical guidelines into local practice, including in the perioperative setting. Under the auspices of a broadly multidisciplinary institutional task force and applying the Consensus-Oriented Decision-Making model, we created two evidence-informed and local expert opinion-supported standardized clinical assessment and management plans for the preoperative management of antiplatelet therapy in patients with a coronary artery stent.SummaryPatient care can be optimized via evidence-based, yet locally developed and reiterative standardized clinical assessment and management plans for patients with coronary artery stents undergoing surgical procedures. Such standardized clinical assessment and management plans can result in greater consistency in care, providing a positive feedback loop in which the care plan itself can be continuously reevaluated, improved, and brought up to date with the most recent available data and knowledge.
    Electronic ISSN: 1471-2253
    Topics: Medicine
    Published by BioMed Central
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  • 6
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    Visual Aids for Multimodal Treatment Options to Support Decision Making of Patients with Colorectal Cancer (2012)
    BioMed Central
    Details
    Publication Date: 2012-10-24
    Description: Background: A variety of multimodal treatment options are available for colorectal cancer and many patients want to be involved in decisions about their therapies. However, their desire for autonomy is limited by lack of disease-specific knowledge. Visual aids may be helpful tools to present complex data in an easy-to-understand, graphic form to lay persons. The aim of the present study was to evaluate the treatment preferences of healthy persons and patients using visual aids depicting multimodal treatment options for colorectal cancer. Methods: We designed visual aids for treatment scenarios based on four key studies concerning multimodal treatment of colorectal cancer. The visual aids were composed of diagrams depicting outcome parameters and side effects of two treatment options. They were presented to healthy persons (n = 265) and to patients with colorectal cancer (n = 102). Results: Most patients and healthy persons could make immediate decisions after seeing the diagrams (range: 88% -- 100%). Patients (79%) chose the intensive-treatment option in the scenario with a clear survival benefit. In scenarios without survival benefit, all groups clearly preferred the milder treatment option (range: 78% - 90%). No preference was seen in the scenario depicting equally intense treatment options with different timing (neoadjuvant vs. adjuvant) but without survival benefit. Conclusions: Healthy persons' and patients' decisions using visual aids seem to be influenced by quality-of-life aspects rather than recurrence rates especially in situations without survival benefit. In the future visual aids may help to improve the management of patients with colorectal cancer.
    Electronic ISSN: 1472-6947
    Topics: Computer Science , Medicine
    Published by BioMed Central
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  • 7
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    Identification and characterization of the bacterial etiology of clinically problematic acute otitis media after tympanocentesis or spontaneous otorrhea in German children (2012)
    BioMed Central
    Details
    Publication Date: 2012-11-21
    Description: Background: Acute Otitis Media (AOM) is an important and common disease of childhood. Bacteria isolated from cases of clinically problematic AOM in German children were identified and characterized Methods: In a prospective non-interventional study in German children between 3 months and less than 60 months of age with Ear, Nose and Throat Specialist --confirmed AOM, middle ear fluid was obtained by tympanocentesis (when clinically indicated) or by careful sampling of otorrhea through/at an existing perforation. Results: In 100 children with severe AOM, Haemophilus influenzae was identified in 21% (18/21, 85.7% were non-typeable [NTHi]), Streptococcus pneumoniae in 10%, S. pyogenes in 13% and Moraxella catarrhalis in 1%. H. influenzae was the most frequently identified pathogen in children from 12 months of age. H. influenzae and S. pneumoniae were equally prevalent in children aged 3--11 months, but S. pyogenes was most frequently isolated in this age group. NTHi AOM disease appeared prevalent in all ages. Conclusions: NTHi, S. pneumoniae and S. pyogenes are implicated as important causes of complicated AOM in children in Germany. NTHi disease appears prevalent in all ages. The impact of vaccination to prevent NTHi and S. pneumoniae AOM may be substantial in this population and is worth investigating.
    Electronic ISSN: 1471-2334
    Topics: Medicine
    Published by BioMed Central
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  • 8
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    Development of a point-of-care-device for fast detection of periodontal pathogens (2015)
    BioMed Central
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    Publication Date: 2015-12-25
    Description: A number of pathogens can cause severe destruction of the periodontal apparatus during the course of periodontitis. The aim of this work was the development of a diagnostic device for the use at the point-of-n...
    Electronic ISSN: 1472-6831
    Topics: Medicine
    Published by BioMed Central
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  • 9
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    Medium-chain acyl-CoA dehydrogenase deficiency associated with a novel splice mutation in the ACADM gene missed by newborn screening (2015)
    BioMed Central
    Details
    Publication Date: 2015-07-31
    Description: Background: Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common disorder of mitochondrial fatty acid β-oxidation and a target disease of newborn screening in many countries.Case presentationWe report on two siblings with mild MCAD deficiency associated with a novel splice site mutation in the ACADM gene. The younger sibling was detected by newborn screening, while the older sister was missed, but diagnosed later on by genetic family testing. Both children were found to be compound heterozygous for the common c.985A 〉 G (p.K329E) mutation and a novel splice site mutation, c.600-18G 〉 A, in the ACADM gene. To determine the biological consequence of the c.600-18G 〉 A mutation putative missplicing was investigated at RNA level in granulocytes and monocytes of one of the patients. The splice site mutation was shown to lead to partial missplicing of the ACADM pre-mRNA. Of three detected transcripts two result in truncated, non-functional MCAD proteins as reflected by the reduced octanoyl-CoA oxidation rate in both patients. In one patient a decrease of the octanoyl-CoA oxidation rate was found during a febrile infection indicating that missplicing may be temperature-sensitive. Conclusions: Our data indicate that the c.600-18G 〉 A variant activates a cryptic splice site, which competes with the natural splice site. Due to only partial missplicing sufficient functional MCAD protein remains to result in mild MCADD that may be missed by newborn screening.
    Electronic ISSN: 1471-2350
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 10
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    Perceptions about the relative importance of patient care-related topics: a single institutional survey of its anesthesiologists, nurse anesthetists, and surgeons (2016)
    BioMed Central
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    Publication Date: 2016-03-23
    Description: Persistently variable success has been experienced in locally translating even well-grounded national clinical practice guidelines, including in the perioperative setting. We have sought greater applicability ...
    Electronic ISSN: 1471-2253
    Topics: Medicine
    Published by BioMed Central
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