Keywords:
Carbohydrate drugs.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (116 pages)
Edition:
1st ed.
ISBN:
9783662468487
Series Statement:
Springer Theses Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=2120625
DDC:
547.78
Language:
English
Note:
Intro -- Supervisor's Foreword -- Acknowledgments -- Contents -- 1 Chemical Synthesis of Proposed RM2 and Derivatives -- 1.1 Introduction -- 1.1.1 Glycosphingolipids -- 1.1.2 Tumor-Associated Carbohydrate Antigens -- 1.1.3 RM2 Antigen ( beta 1,4-GalNAc-Disialyl-Lc4) as a New Marker for Prostate Cancer -- 1.2 Chemical Synthesis of Hexasaccharide RM2 and Its Derivatives -- 1.2.1 Design of Sugar Building Blocks -- 1.2.2 Syntheses of Sialyated Trisaccharide Building Block 1-D -- 1.2.3 Synthesis of Galactose Building Block 1-5 -- 1.2.4 Synthesis of Sialylated Trisaccharide Building Block 1-2 -- 1.2.5 Synthesis of GlcNAc Building Block 1-12 -- 1.2.6 Synthesis of Trisaccharide 1-2 -- 1.2.7 Synthesis of Disaccharide 1-17 -- 1.2.8 Examine Synthesis of Hexasaccharide -- 1.2.9 Hexasaccharide RM2 Antigen: Investigate Sial alpha 2 2192 3Gal Disaccharide with High alpha -Stereoselectivity and Yield -- 1.2.10 Syntheses of Truncated RM2 Derivatives 1-44, 1-46, 1-48, and 1-50 -- 1.3 Summary -- 1.3.1 Experimental Section -- References -- 2 RM2 Antigen: Structural Characterization and Determination of KD,Surf for Multivalent Carbohydrate--Protein Interaction -- 2.1 Introduction -- 2.1.1 A Novel Ganglioside (RM2) Isolated from Renal Cell Carcinoma -- 2.2 Characterize the Structure of RM2 Antigen by Monoclonal RM2 Antibody and Further Determine the KD,Surf by Carbohydrate--Protein Interaction -- 2.2.1 Structural Characterization of RM2 Antigen -- 2.2.2 Determination of KD,Surf for Multivalent Carbohydrate--Protein Interaction on the Surface -- 2.3 Summary -- 2.4 Experimental Section -- References -- 3 RM2 Antigen: Synthesis of Glycoconjugates -- 3.1 Introduction -- 3.1.1 Carbohydrate-Based Vaccines -- 3.1.2 Applications of Glycolipids as Immunological Adjuvants -- 3.2 Generation and Characterization of RM2 Glycoconjugate.
,
3.2.1 Synthesis of DT-RM4.7 as a Vaccine Candidate with Glycolipid C34 as a Potent Adjuvant -- 3.2.2 Search for the Best Epitope Ratio of DT-RM Vaccine Adjuvanted with C34 -- 3.2.3 Synthesis of RM2 Conjugated with Different Carrier Proteins -- 3.3 Summary -- 3.4 Experimental Section -- References -- 4 Synthesis of Heptasaccharide RM2 Prostate Tumor Antigen: Chemical Synthesis of Heptasaccharide and Tetrasaccharide (Inner Core of the RM2 Antigen) -- 4.1 Introduction -- 4.1.1 Heptasaccharide Form and Hexasaccharide Form of RM2 Antigen -- 4.2 Chemical Synthesis of Proposed Heptasaccharide -- 4.2.1 Chemical Synthesis of Heptasaccharide 3-5 and Tetrasaccharide 3-6 -- 4.2.2 Synthesis of Galactose Building Block 4-4 -- 4.2.3 Synthesis of Disaccharide Building Block 4-9 -- 4.2.4 Synthesis of Sialylated Tetrasaccharide Building Block 4-2 -- 4.2.5 Synthesis of Compound 4-2 -- 4.3 Summary -- 4.4 Experimental Section -- References.
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