In:
Current Organic Synthesis, Bentham Science Publishers Ltd., Vol. 15, No. 2 ( 2018-04-24), p. 246-255
Abstract:
Aim and Objective: [(9H-Fluoren-9-yl)methoxy]carbonyl (Fmoc)-protected 2-aminoethanesulfonyl chlorides with various functionalized 1-substituents may be of use as building blocks for the Fmoc strategic
synthesis of sulfonopeptides. Materials and Method: Fmoc-protected 2-aminoethanesulfonyl chlorides with different functionalized 1-
substituents were synthesized via radical addition of N-Fmoc allylamine and xanthates with functionalized Ssubstituents, and subsequent oxidative chlorination with N-chlorosuccimide/HCl. Results: Fmoc-protected 2-aminoethanesulfonyl chlorides with different functionalized 1-substituents were
synthesized via radical addition and subsequent oxidative chlorination. The mechanism on the oxidative chlorination is proposed. Conclusion: The current method is an expeditious, convenient, and practical method for the synthesis of Fmocprotected
2-aminoethanesulfonyl chlorides with different functionalized 1-substituents in good to excellent yields.
Type of Medium:
Online Resource
ISSN:
1570-1794
DOI:
10.2174/1570179414666170821120705
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2018
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