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  • Bentham Science Publishers Ltd.  (4)
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  • Bentham Science Publishers Ltd.  (4)
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  • 1
    Online Resource
    Online Resource
    Research progress on the mechanism of intestinal barrier damage and drug therapy in a high altitude environment
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Drug Delivery Vol. 20 ( 2023-03-09)
    Details
    In: Current Drug Delivery, Bentham Science Publishers Ltd., Vol. 20 ( 2023-03-09)
    Abstract: The plateau is a typical extreme environment with low temperature, low oxygen and high ultraviolet rays. The integrity of the intestinal barrier is the basis for the functioning of the intestine, which plays an important role in absorbing nutrients, maintaining the balance of intestinal flora, and blocking the invasion of toxins. Currently, there is increasing evidence that high altitude environments can enhance intestinal permeability and disrupt intestinal barrier integrity. This article mainly focuses on the regulation of the expression of HIF and tight junction proteins in the high altitude environment, which promotes the release of pro-inflammatory factors, especially the imbalance of intestinal flora caused by the high altitude environment. The mechanism of intestinal barrier damage and the drugs to protect the intestinal barrier are reviewed. Studying the mechanism of intestinal barrier damage in high altitude environment is not only conducive to understanding the mechanism of high altitude environment affecting intestinal barrier function, but also provides a more scientific medicine treatment method for intestinal damage caused by the special high altitude environment.
    Type of Medium: Online Resource
    ISSN: 1567-2018
    URL: Article
    DOI: 10.2174/1567201820666230309090241
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    The Role of VD/VDR Signaling Pathway in Autoimmune Skin Diseases
    Bentham Science Publishers Ltd. ; 2023
    In:  Mini-Reviews in Medicinal Chemistry Vol. 23, No. 6 ( 2023-04), p. 652-661
    Details
    In: Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 23, No. 6 ( 2023-04), p. 652-661
    Abstract: Immune-related cutaneous diseases are a series of disorders, such as alopecia areata, psoriasis, atopic dermatitis, systemic lupus erythematosus and autoimmune bullous dermatoses. Vitamin D is a fat-soluble vitamin, which is known for its classical pleiotropic effect. Recent studies have found that vitamin D, after catalyzed into its biologically active form [1,25(OH) 2D] , correlated with its receptor, vitamin D receptor, plays a vital role in multiple pathophysiological processes, including immune-related dermatoses. This review mainly summarizes evidence on the role of vitamin D/vitamin D receptor in immune-related cutaneous diseases and the potential therapeutic targets for skin disorders. Methods: We have carried out a comprehensive literature search in PubMed and Google Scholar databases using keywords like “vitamin D”, “vitamin D receptor”, “immune”, “psoriasis”, “atopic dermatitis”, “skin”, “systemic lupus erythematosus”, “alopecia areata” and “autoimmune bullous dermatoses”. Only articles related to the topic were included in this review. Conference, patent, graduation thesis and articles without available full text were excluded. Results: Vitamin D/vitamin D receptor is critical for skin in regulating the proliferation and differentiation of keratinocytes, keeping the integrity of the skin barrier as well as maintaining the homeostasis of the “skin's immune system”. Vitamin D deficiency/vitamin D receptor mutations are potential risk factors for some immune-related cutaneous diseases. Conclusion: Vitamin D is a pleiotropic hormone, which is important in the homeostasis of human body. Many studies have revealed vitamin D deficiency in several skin diseases. Thus, vitamin D supplementation may be a useful therapeutic option for immune-related skin diseases.
    Type of Medium: Online Resource
    ISSN: 1389-5575
    URL: Article
    DOI: 10.2174/1389557523666221124123206
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Research Progress of Epigenetic Modification on the Regulation of Transporters Under Hypoxia
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Drug Metabolism Vol. 24, No. 2 ( 2023-02), p. 106-113
    Details
    In: Current Drug Metabolism, Bentham Science Publishers Ltd., Vol. 24, No. 2 ( 2023-02), p. 106-113
    Abstract: Epigenetic modification refers to the heritable changes caused by chromosomal changes without changing the DNA sequence. Epigenetics runs through the entire growth and differentiation process of the body, which causes varied diseases. Hypoxia is a physiological astate of lowered partial oxygen partial pressure that affects cell and tissue function. Transporters are proteins that maintain a normal and stable state of cells. Transporter's expression levels when hypoxia occurs influence the absorption, distribution, metabolism, and excretion of drugs, thereby affecting the utilization and efficacy of drugs. Epigenetic modification is assumed to play an important role in the metabolism of drugs. Changes in epigenetic modification and transporter expression levels under hypoxia are explored in our work, and the effect of epigenetic modification on transporter expression and how this regulatory mechanism works and affects drugs under hypoxia are questioned. It is important for drug development, treatment of diseases and rational use of drugs.
    Type of Medium: Online Resource
    ISSN: 1389-2002
    URL: Article
    DOI: 10.2174/1389200224666230405115442
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Sodium-Glucose Cotransporter 2 Inhibitors and Pathological Myocardial Hypertrophy
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Drug Targets Vol. 24 ( 2023-09-07)
    Details
    In: Current Drug Targets, Bentham Science Publishers Ltd., Vol. 24 ( 2023-09-07)
    Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new type of oral hypoglycemic drugs that exert a hypoglycemic effect by blocking the reabsorption of glucose in the proximal renal tubules, thus promoting the excretion of glucose from urine. Their hypoglycemic effect is not dependent on insulin. Increasing data shows that SGLT2 inhibitors improve cardiovascular outcomes in patients with type 2 diabetes. Previous studies have demonstrated that SGLT2 inhibitors can reduce pathological myocardial hypertrophy with or without diabetes, but the exact mechanism remains to be elucidated. To clarify the relationship between SGLT2 inhibitors and pathological myocardial hypertrophy, with a view to providing a reference for the future treatment thereof, this study reviewed the possible mechanisms of SGLT2 inhibitors in attenuating pathological myocardial hypertrophy. We focused specifically on the mechanisms in terms of inflammation, oxidative stress, myocardial fibrosis, mitochondrial function, epicardial lipids, endothelial function, insulin resistance, cardiac hydrogen and sodium exchange, and autophagy.
    Type of Medium: Online Resource
    ISSN: 1389-4501
    URL: Article
    DOI: 10.2174/1389450124666230907115831
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
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