In:
Current Molecular Medicine, Bentham Science Publishers Ltd., Vol. 20, No. 9 ( 2021-01-19), p. 723-732
Abstract:
Astroglioma, one major form of brain tumors, has remained principalAstroglioma, one major form of brain tumors, has remained
principally tough to handle for decades, due to the complexity of tumor pathology and the poor response to chemo- and radio-therapies.ly tough
to handle for decades, due to the complexity of tumor pathology and the poor response to chemo- and radio-therapies. Our previous study demonstrated that nifurtimox could
regulate the signaling axis of AKT-GSK3β in various tumor types including the astroglioma U251 cells. Intriguingly, earlier case studies suggested that nifurtimox could
possibly permeate the blood brain barrier and arrest neuroblastoma in the brain. These observations jointly encouraged us to explore whether nifurtimox would hinder the
growth of astroglioma in vivo. Our results exhibited that nifurtimox could competently hinder the development of astroglioma in the mouse brain as compared to
temozolomide, the first line of drug for brain tumors. Meanwhile the surviving rate, as well as the body-weight was dramatically upregulated upon nifurtimox treatment, as
compared to that of temozolomide. These findings offered nifurtimox as a better alternative drug in treating astroglioma in vivo. Persistently, the manipulation of the
signaling axis of AKT-GSK3β in astroglioma was found in line with earlier findings in neuroblastoma when treated with nifurtimox. Methods: Our previous study demonstrated that nifurtimox could regulate the signaling
axis of AKT-GSK3β in various tumor types including the astroglioma U251 cells. Intriguingly, earlier case studies suggested that nifurtimox could possibly permeate the
blood brain barrier and arrest neuroblastoma in the brain. These observations jointly encouraged us to explore whether nifurtimox would hinder the growth of astroglioma in
vivo. Results: Our results exhibited that nifurtimox could competently hinder the development
of astroglioma in the mouse brain as compared to temozolomide, the first line of drug for brain tumors. Meanwhile the surviving rate, as well as the body-weight was dramatically
upregulated upon nifurtimox treatment, as compared to that of temozolomide. These findings offered nifurtimox as a better alternative drug in treating astroglioma in vivo. Conclusion: Persistently, the manipulation of the signaling axis of AKT-GSK3β in
astroglioma was found in line with earlier findings in neuroblastoma when treated with nifurtimox.
Type of Medium:
Online Resource
ISSN:
1566-5240
DOI:
10.2174/1566524020666200409124258
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
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