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  • 1
    Online Resource
    Online Resource
    Medicinal Plants and Cancer Chemoprevention
    Bentham Science Publishers Ltd. ; 2008
    In:  Current Drug Metabolism Vol. 9, No. 7 ( 2008-09-01), p. 581-591
    Details
    In: Current Drug Metabolism, Bentham Science Publishers Ltd., Vol. 9, No. 7 ( 2008-09-01), p. 581-591
    Type of Medium: Online Resource
    ISSN: 1389-2002
    URL: Article
    DOI: 10.2174/138920008785821657
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2008
    SSG: 15,3
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  • 2
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    Relationship between Subclinical Hypothyroidism and Uremic Pruritis in Hemodialysis Patients
    Bentham Science Publishers Ltd. ; 2024
    In:  Endocrine, Metabolic & Immune Disorders - Drug Targets Vol. 24, No. 2 ( 2024-02), p. 235-241
    Details
    In: Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 24, No. 2 ( 2024-02), p. 235-241
    Abstract: Uremic pruritus (UP) is one of the most distressing symptoms in hemodialysis (HD) patients. Subclinical hypothyroidism (SCH) is a biochemical condition with high prevalence in HD patients. The present multicentric study aimed to assess the relationship between UP and SCH in HD patients. Methods: The present cross-sectional study included 328 HD patients. All patients were submitted to careful history through clinical examination and standard laboratory assessment. Pruritis was evaluated using the pruritis visual analog scale (VAS). Patients were diagnosed with SCH if they had TSH levels above the upper limit of the normal reference range in association with normal free thyroxine (FT4) levels. Results: Among the studied patients, there were 196 patients (59.8 %) with UP. Comparison be-tween patients with UP and patients without revealed that patients in the former group had signifi-cantly longer HD duration (median (IQR): 47.5 (27.0-72.5) versus 36.0 (23.0-50.5) months, p  0.001) and lower Kt/v (median (IQR): 1.4 (1.09-1.7) versus 1.54 (1.12-1.91), p = 0.009). Moreover, they had significantly higher ferritin (median (IQR): 653.0 (526.0-800.0) versus 628.0 (470.8-716.0) ng/mL), hsCRP (median (IQR): 12.0 (8.0-14.0) versus 8.0 (6.0-9.0) mg/dL, p  0.001) and TSH levels (median (IQR): 4.34 (1.98-5.2) versus 3.34 (1.9-4.85) μIU/ml) with a significantly higher frequency of SCH (45.9 % versus 28.8 %, p = 0.002). Logistic regression analysis identified hemodialysis duration (OR (95%) CI): 1.02 (1.009-1.028), p  0.001), ferritin levels (OR (95% CI): 1.002 (1.001-1.003), p  0.001), and SCH (OR (95% CI): 0.54 (0.32-0.89), p = 0.016) as significant predictors of UP. Conclusion: The present study suggested a possible link between SCH and the development of UP in HD patients.
    Type of Medium: Online Resource
    ISSN: 1871-5303
    URL: Article
    DOI: 10.2174/1871530323666230509103021
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2024
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  • 3
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    Online Resource
    Role of Both Protein C and Antithrombin III as Predictors of Stage of Liver Disease in Chronic Viral Hepatitis B or C Infected Patients
    Bentham Science Publishers Ltd. ; 2020
    In:  Endocrine, Metabolic & Immune Disorders - Drug Targets Vol. 20, No. 1 ( 2020-01-07), p. 112-117
    Details
    In: Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 20, No. 1 ( 2020-01-07), p. 112-117
    Abstract: Chronic liver disease is characterized by complex hemostatic disorders because the liver is the site where most of the coagulation factors and their inhibitors are synthesized. The aim of this study was the evaluation of protein C and antithrombin III in different stages of chronic hepatitis B and C and to determine their possible role as markers of liver cell damage in different clinical stages. Methods: The study included 60 subjects who were subdivided into 4 groups: (Group I): 15 patients diagnosed as chronic viral hepatitis B or C, (Group II): 15 patients with compensated liver cirrhosis, (Group III): 15 patients with decompensated liver cirrhosis, and (Group IV) (control group): 15 healthy individuals. History taking, clinical examination and abdominal ultrasonography were made for all subjects. Investigations were done in the form of liver function tests (ALT, AST, ALP, serum bilirubin, and serum albumin), PT, PTT, CBC. Plasma levels of Antithrombin III & protein C were estimated by automated Stago compact coagulation analyzer. Results: In all patient groups, the mean value of Protein C showed significant decrease when compared to control group, mean value of antithrombin III showed a significant decrease in compensated and decompensated subjects when compared to chronic hepatitis and control groups. Antithrombin III and protein C showed a significant negative correlation with (ALT, AST, PT, PTT, INR). However, this correlation was positive with Albumin. Conclusion: Antithrombin III and protein C are natural anticoagulants and can be considered as markers of different stages of chronic liver disease. This is supported further by the comparison between the levels of these parameters and clinical stages of liver disease. Protein C is more sensitive than ATIII as a marker of hepatocellular damage.
    Type of Medium: Online Resource
    ISSN: 1871-5303
    URL: Article
    DOI: 10.2174/1871530319666190529092555
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
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  • 4
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    Online Resource
    Click Synthesis, Anticancer Activity and Molecular Docking Studies on Pyridazinone Scaffolds
    Bentham Science Publishers Ltd. ; 2018
    In:  Current Organic Chemistry Vol. 22, No. 23 ( 2018-12-17), p. 2300-2307
    Details
    In: Current Organic Chemistry, Bentham Science Publishers Ltd., Vol. 22, No. 23 ( 2018-12-17), p. 2300-2307
    Type of Medium: Online Resource
    ISSN: 1385-2728
    URL: Article
    DOI: 10.2174/1385272822666181029111943
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2018
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  • 5
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    Electron Microscopic and Pathological Changes in Lung Cancer after Intratumoral Injection of Sodium Bicarbonate
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Cancer Therapy Reviews Vol. 18, No. 2 ( 2022-05), p. 123-130
    Details
    In: Current Cancer Therapy Reviews, Bentham Science Publishers Ltd., Vol. 18, No. 2 ( 2022-05), p. 123-130
    Abstract: Lung cancer can be treated with surgery, chemotherapy, radiation therapy, targeted therapy, and palliative care. Palliative therapy is applied for inoperable lung cancer as it induces tumour necrosis. PH of tumour tissue is acidic; application of sodium bicarbonate (SB) into lung cancer locally via bronchoscopy can change its core pH, which may lead to tumour destruction. We aimed to study the ultrastructural characteristics of lung cancer and assess the destructive effects of sodium bicarbonate 8.4 % local injection on tumour tissue integrity by light and electron microscopies. Methods: This study was conducted on 21 patients with central bronchial carcinoma diagnosed according to WHO classification 2015. Three bronchoscopic biopsies were taken; two biopsies before and one after injection of sodium bicarbonate 8.4 % solution of 20 ml via transbronchial needle. All biopsies were examined by both light and electron microscopes. The first biopsy was examined to diagnose the tumour morphologically with and without immunostaining. Second and third biopsies were taken before and after SB 8.4 % injection to compare pathological changes in tumour tissue integrity as well as cellular ultra-structures. Different lung cancer pathological types were included in the study. Results: Tumour tissue integrity and pathological changes were examined in biopsies before and after injection of sodium bicarbonate 8.4 %. Extensive necrosis in all cell types of lung cancer was seen after injection of SB; this important finding was delineated by both light and electron microscopies. Conclusion: Preliminary ultrastructural study of small biopsy of lung tumors has a complementary role in both morphological and immunohistochemical studies. Local injection of sodium bicarbonate into lung cancer induces extensive necrosis that may reflect its important therapeutic role in lung cancer.
    Type of Medium: Online Resource
    ISSN: 1573-3947
    URL: Article
    DOI: 10.2174/1573394717666211119102907
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 6
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    The Effect of Stem Cell Transplantation Therapy for Post Viral Chronic Liver Cell Failure on Associated Type II Diabetes Mellitus: A Pilot Study
    Bentham Science Publishers Ltd. ; 2020
    In:  Endocrine, Metabolic & Immune Disorders - Drug Targets Vol. 20, No. 6 ( 2020-07-17), p. 903-916
    Details
    In: Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 20, No. 6 ( 2020-07-17), p. 903-916
    Abstract: It was observed that type II diabetes mellitus associated with chronic liver failure improved after stem cell transplantation. However, there were no adequate studies regarding this issue. The aim of this study was to evaluate the effect of stem cell transplantation on associated type II diabetes mellitus and on the liver function tests. Methods: This pilot study included 30 patients of post-hepatitis chronic liver failure who were classified into two groups: Group I included patients with chronic liver cell failure associated with type 2 diabetes. Group II included patients without type II diabetes. Autologous CD34+ and CD133+ stem cells were percutaneously infused into the portal vein. Responders (regarding the improvement of diabetes as well as improvement of liver condition) and non-responders were determined. Patients were followed up for one, three and six months after the intervention evaluating their three-hour glucose tolerance test, C- peptide (Fasting and postprandial), Child-Pugh score and performance score one month, three months, and six months after stem cell therapy. Results: Both synthetic and excretory functions of the liver were improved in 10 patients (66.66 %) of group I and in 12 patients (80 %) of group II. Significant improvement in the Oral Glucose Tolerance Test in the responders of both the groups was well defined from the 3rd month and this was comparable to changes in liver function tests and Child-Pugh score. Conclusions: Successful stem cell therapy in chronic liver cell failure patients can improve but not cure the associating type 2 diabetes by improving insulin resistance.
    Type of Medium: Online Resource
    ISSN: 1871-5303
    URL: Article
    DOI: 10.2174/1871530319666191202125402
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
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  • 7
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    Relation between Soluble CD14 Levels, Inflammation, Subclinical Atherosclerosis and Mortality in Hemodialysis Patients
    Bentham Science Publishers Ltd. ; 2023
    In:  Endocrine, Metabolic & Immune Disorders - Drug Targets Vol. 23, No. 6 ( 2023-05), p. 843-849
    Details
    In: Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 6 ( 2023-05), p. 843-849
    Abstract: Chronic kidney disease (CKD) is characterized by persistent lowgrade inflammation. Soluble CD14 (sCD14) is involved in many pathological conditions, including inflammation and atherosclerosis. The present study aimed to assess the relationship between sCD14 levels, subclinical atherosclerosis (SCA), inflammation and mortality in Egyptian hemodialysis (HD) patients. Patients and Methods: The present longitudinal study included 62 HD patients. All patients were submitted to careful history taking, thorough clinical examination and laboratory assessment for high-sensitivity C-reactive protein (hsCRP) and sCD14. Carotid intima-media thickness (CIMT) was also assessed. Patients were followed for a maximum of 18 months. The primary outcome is patients’ mortality. Data were statistically analyzed using standard descriptive, comparative, correlative and regression methods. Results: The present study was conducted on 62 HD patients. They comprised 34 males and 28 females with an age of 54.6 ± 9.0 years. At the end of follow-up, 12 patients (19.4 %) died. It was shown that survivors had significantly lower hsCRP levels (104.2 ± 38.2 versus 134.1 ± 15.3 mg/dL, p 〈 0.001), lower sCD14 levels (32.7 ± 10.3 versus 47.4 ± 18.4 μg/mL, p = 0.02) and lower CIMT (1.32 ± 0.5 versus 1.5 ± 0.2 mm, p = 0.049). sCD14 levels were significantly correlated with hsCRP (r = 0.4, p = 0.001) and CIMT (r = 0.31, p = 0.013). Multivariate analysis identified HD duration [HR (95% CI): 1.02 (1.0-1.04), p = 0.021] and sCD14 levels [HR (95% CI): 1.06 (1.0-1.12), p = 0.026] as significant predictors of patients’ survival. Conclusions: sCD14 levels in this cohort of HD patients are well-correlated with hsCRP levels and CIMT. In addition, they are significant predictors of patients’ mortality.
    Type of Medium: Online Resource
    ISSN: 1871-5303
    URL: Article
    DOI: 10.2174/1871530322666221011091606
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 8
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    Online Resource
    Amyloid A in Serum and Ascitic Fluid as a Novel Diagnostic Marker of Spontaneous Bacterial Peritonitis
    Bentham Science Publishers Ltd. ; 2020
    In:  Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Vol. 19, No. 2 ( 2020-06-08), p. 140-148
    Details
    In: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 19, No. 2 ( 2020-06-08), p. 140-148
    Abstract: Diagnosis of Spontaneous Bacterial Peritonitis (SBP) depends mainly on ascetic fluid culture which may be negative in spite of the clinical suggestion of SBP and high ascetic fluid neutrophilic count. Aim: This study aimed to evaluate the biological importance of amyloid A biomarker in both serum and ascetic fluid to diagnose SBP as early as possible and to compare it to other markers (C-reactive protein (CRP), and the neutrophil-to-lymphocyte ratio (NLR)). Methods: This study included 37 patients with hepatic ascites; twenty-two of them had SBP, and 15 patients did not have SBP. Serum and ascetic fluid amyloid A, ascetic fluid neutrophil, C-reactive protein, and neutrophil-to-lymphocyte ratio were measured in all subjects before the start of antimicrobial chemotherapy to the infected ones. Results: Both the serum and ascetic fluid amyloid and also, CRP were significantly higher in patients infected with ascetic fluid than others. The cut-off point of serum amyloid A for early detection of SBP was 9.25ug/ml with the high sensitivity and specificity. For ascetic amyloid A, the sensitivity and specificity were 90.09% and 60% at cut-off point 2.85ug/ml, respectively. Conclusion: Amyloid A in serum and ascitic fluid can be considered as a good biomarker for early diagnosis of SBP.
    Type of Medium: Online Resource
    ISSN: 1871-5230
    URL: Article
    DOI: 10.2174/1871523018666190401154447
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
    SSG: 15,3
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  • 9
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    Online Resource
    Impact on Growth and Secondary Metabolites in White Poplar (Populus alba L.) Callus using SeNPs@Moringa
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Materials Science Vol. 15, No. 2 ( 2022-07), p. 175-191
    Details
    In: Current Materials Science, Bentham Science Publishers Ltd., Vol. 15, No. 2 ( 2022-07), p. 175-191
    Abstract: Green synthesis of nanoparticles has provided a cost-effective, environmentally friendly method, as well as raised safe str ategies for the synthesis of nanomaterials. Methods: In this study, we investigated the synthesis of Selenium nanoparticles from the leaf aqueous extract of Moringa oleifera (MO-SeNPs) and studied the effect of MO-SeNPs and Moringa extract with various concentrations on the growth, active constituents, and antioxidant activity (scavenging DPPH) of Populus alba callus. MS medium supplemented with (2, 4-D at 2 mg/l + 0.5 mg/l BA) took the maximum callus induction percentage (100%), increasing the callus fresh weight, dry weight, and degree of callus formation compared with (2.0 mg/l 2,4-D + 0.5 mg/l Kin). Results: The highest values of callus fresh and dry weight were recorded on MS containing 20% MO-SeNPs. Regarding the active constituents, the GC-MS chromatogram revealed the presence of 23 major compounds identified in the chloroform extract. The phytoconstituents with maximum peak area in callus extract are Tetradecane, Hexadecen-1-ol, Trans-9, 5-Octadecene, (Benzene, 1- pentyloctyl), (Benzene, 1-butylnonyl), Cycloeicosane, and 10-Heneicosene in all treatments. Moringa extract and MO-SeNPs stimulate the increase of compounds in callus compared to control. In this regard, MO-SeNPs 5% led to a higher increase in the area percent of active substances compared to the treatment of Moringa extract and control. Concerning the antioxidant activity, the results indicated that Moringa extract and MO-SeNPs had a positive effect on scavenging DPPH compared with the control. The highest percentages of scavenging DPPH were recorded when Populus alba L. callus treated with MO-SeNPs 20%, 10%, and Moringa extract 20%, percentages reached (84.65, 75.35, and 71.94%), respectively. Conclusion : Green synthesis of MO-SeNPs improved secondary metabolites and antioxidant activity in Populus alba L. callus.
    Type of Medium: Online Resource
    ISSN: 2666-1454
    URL: Article
    DOI: 10.2174/2666145414666211125093640
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 10
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    Effect of Ketamine versus Dexmedetomidine on Release of Inflammatory Mediators in Laparoscopic Hysterectomy. A Randomized Trial
    Bentham Science Publishers Ltd. ; 2024
    In:  The Open Anesthesia Journal Vol. 18, No. 1 ( 2024-01-10)
    Details
    In: The Open Anesthesia Journal, Bentham Science Publishers Ltd., Vol. 18, No. 1 ( 2024-01-10)
    Abstract: Surgery and anesthesia are sources of patients' stress and release of inflammatory mediators that have adverse effects on wound healing and remote organs. Objectives: To compare the effects of dexmedetomidine and ketamine on perioperative serum levels of inflammatory biomarkers (interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP). Methods: We included 75 patients aged 30-60, ASA I and II, and scheduled for laparoscopic hysterectomy. Randomized patients received either intraoperative ketamine (bolus dose 0.25mg/kg then continuous infusion of 250µg/kg/h), dexmedetomidine (1µg/kg bolus dose then continuous infusion of 0.5µg/kg/h), or placebo. The primary outcome was to measure perioperative inflammatory biomarkers. Hemodynamic parameters, Recovery time, and complications were secondary outcomes. Results: At 6 and 24 hours, IL-6 significantly increased in the control group versus ketamine and dexmedetomidine groups (113.4±14.1,107.4±13.7;50.1± 8.1,48.2± 8.1;47.7±7.1, 46.01±7.1; p 〈 0.001). Similarly, At 6 and 24 hours, TNF-α significantly increased in the control group versus ketamine and dexmedetomidine groups (81.8±18.6,72.7±16.4; 40.6±7.1, 39.2±6.9;41.6± 7.6,39.9±7.6; p 〈 0.001).The same for CRP (17.4±3.6,40.0±6.0;10.2±1.3,16.2± 1.2;10.9±1.8,16.3±1.9; p 〈 0.001). Regarding hemodynamic parameters, there were significant increases in the ketamine group and decreases in the dexmedetomidine group compared to baseline. Recovery time was significantly longer in the ketamine group than in the control and dexmedetomidine group (24.3±6.4,12.6±2.0,13.5±3.3 min, respectively; P 〈 0.001). There were no significant differences between the three groups regarding agitation, nausea, and vomiting ( P= 1,0.126,0.776, respectively). Conclusion: Both dexmedetomidine and ketamine could attenuate the inflammatory response. However, dexmedetomidine has a shorter recovery time. Trial Registry No Trial registry at Pan African Clinical Trials Registry. The number is (PACTR201910617459894: date of registration 10/24/2019). URL https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=9479).
    Type of Medium: Online Resource
    ISSN: 2589-6458
    URL: Article
    DOI: 10.2174/0125896458278196231229121146
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2024
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