In:
Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 21, No. 4 ( 2021-02-16), p. 471-499
Abstract:
In the present study, authors want to encourage the research exertions through structureactivity
relationship for the identification of effective molecules for the treatment of Human immunodeficiency virus because nowadays AIDS is considered as one of the main causes of death in human
beings. A diversity of biological resources has been searched and developed for the treatment of HIV but unfortunately, until now, no medicine is found to be fully effective and safe for the cure of patients.
Human immunodeficiency virus is a type of lentivirus which causes the infection of HIV and once it enters the human body, it stays for a longer period of time triggering immunodeficiency syndrome. For
searching and developing new potent and effective anti-HIV molecules, medicinal chemists have engaged in countless targets with the structure-activity relationship (SAR) of molecules and on this basis,
many antiretroviral therapies have been developed to cure HIV infection. Most of these new searched molecules have been found to be clinically active against various types of AIDS patient and auxiliary
resea rch in this area may lead to better treatment in the near future. This article encompasses and highlights
the recent advancement of innumerable inhibitors laterally through synthetic, semi-synthetic and structure-activity relationship approaches.
Type of Medium:
Online Resource
ISSN:
1389-5575
DOI:
10.2174/1389557519666190312170158
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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