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  • 1
    Online Resource
    Online Resource
    COX-2 Signaling and Cancer: New Players in Old Arena
    Bentham Science Publishers Ltd. ; 2014
    In:  Current Drug Targets Vol. 15, No. 3 ( 2014-02-31), p. 347-359
    Details
    In: Current Drug Targets, Bentham Science Publishers Ltd., Vol. 15, No. 3 ( 2014-02-31), p. 347-359
    Type of Medium: Online Resource
    ISSN: 1389-4501
    URL: Article
    DOI: 10.2174/1389450115666140127102915
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2014
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    C2F: Coarse-to-Fine Vision Control System for Automated Microassembly
    Bentham Science Publishers Ltd. ; 2019
    In:  Nanoscience &Nanotechnology-Asia Vol. 9, No. 2 ( 2019-06-25), p. 229-239
    Details
    In: Nanoscience &Nanotechnology-Asia, Bentham Science Publishers Ltd., Vol. 9, No. 2 ( 2019-06-25), p. 229-239
    Abstract: In this paper, authors present the development of a completely automated system to perform 3D micromanipulation and microassembly tasks. The microassembly workstation consists of a 3 degree-of-freedom (DOF) MM3A® micromanipulator arm attached to a microgripper, two 2 DOF PI® linear micromotion stages, one optical microscope coupled with a CCD image sensor, and two CMOS cameras for coarse vision. Methods: The whole control strategy is subdivided into sequential vision based routines: manipulator detection and coarse alignment, autofocus and fine alignment of microgripper, target object detection, and performing the required assembly tasks. A section comparing various objective functions useful in the autofocusing regime is included. Results: The control system is built entirely in the image frame, eliminating the need for system calibration, hence improving speed of operation. A micromanipulation experiment performing pick-and-place of a micromesh is illustrated. Conclusion: This demonstrates a three-fold reduction in setup and run time for fundamental micromanipulation tasks, as compared to manual operation. Accuracy, repeatability and reliability of the programmed system is analyzed.
    Type of Medium: Online Resource
    ISSN: 2210-6812
    URL: Article
    DOI: 10.2174/2210681208666180119143039
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2019
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  • 3
    Online Resource
    Online Resource
    Extensive Multifocal Emphysematous Osteomyelitis of Spine: A Rare Case and a Review of Literature
    Bentham Science Publishers Ltd. ; 2023
    In:  Infectious Disorders - Drug Targets Vol. 23, No. 1 ( 2023-02)
    Details
    In: Infectious Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 1 ( 2023-02)
    Abstract: Emphysematous osteomyelitis (EO) is an extremely rare form of osteomyelitis which is complicated mainly by infection with gas-forming organisms. The common causative agents of this disease are mainly members of Enterobacteriaceae family, the most common are Escherichia coli and Klebsiella pneumoniae along with anaerobes. A total of 48 cases of EO have been reported in the literature till now globally and none have documented the isolation of Corynebacterium amycolatum. Case Presentation: We report a rare case of emphysematous osteomyelitis of the spine and pelvis due to Escherichia coli along with the isolation of Corynebacterium amycolatum from the same pus samples on two consecutive occasions in a 50-year-old female with uncontrolled diabetes mellitus, who was successively treated with antibiotics and drainage of pus. We also did a brief review of the literature of all cases reported till now. Conclusion: The role of Corynebacterium amycolatum in the etiology of emphysematous osteomyelitis needs to be evaluated further in future studies as we cannot completely ignore its isolation in two consecutive samples as a mere contaminant.
    Type of Medium: Online Resource
    ISSN: 1871-5265
    URL: Article
    DOI: 10.2174/1871526522666220614163310
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Lipid Metabolism and Mitochondria: Cross Talk in Cancer
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Drug Targets Vol. 23, No. 6 ( 2022-04), p. 606-627
    Details
    In: Current Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 6 ( 2022-04), p. 606-627
    Abstract: Metabolic reprogramming is considered a major event in cancer initiation, progression and metastasis. The metabolic signature of cancer cells includes alterations in glycolysis, mitochondrial respiration, fatty acid/lipid and amino acid metabolism. Being at a junction of various metabolic pathways, mitochondria play a key role in fueling cancer growth through regulating bioenergetics, metabolism and cell death. Increasing evidence suggests that alteration in lipid metabolism is a common feature of metastatic progression, including fatty acid synthesis as well as fatty acid oxidation. However, the interplay between lipid metabolism and mitochondria in carcinogenesis remains obscure. The present review focuses on key lipid metabolic pathways associated with mitochondrial regulation that drive cancer phenotype and metastasis. We also review potential targets of lipid metabolism and mitochondria to improve the therapeutic regime in cancer patients. This review aims to improve our current understanding of the intricate relation of lipids with mitochondria and provides insights into new therapeutic approaches.
    Type of Medium: Online Resource
    ISSN: 1389-4501
    URL: Article
    DOI: 10.2174/1389450122666210824144907
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    NF-κB Down–regulation and PARP Cleavage by novel 3-α-butyryloxy-β-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression
    Bentham Science Publishers Ltd. ; 2013
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 13, No. 5 ( 2013-05-01), p. 777-790
    Details
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 13, No. 5 ( 2013-05-01), p. 777-790
    Type of Medium: Online Resource
    ISSN: 1871-5206
    URL: Article
    DOI: 10.2174/1871520611313050012
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2013
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    A Review on Polymeric Invasive and Non-Invasive Nanocarriers Assisted Transdermal Drug Delivery for Improved Penetration and Bioavailability
    Bentham Science Publishers Ltd. ; 2022
    In:  Drug Delivery Letters Vol. 12, No. 1 ( 2022-03), p. 19-34
    Details
    In: Drug Delivery Letters, Bentham Science Publishers Ltd., Vol. 12, No. 1 ( 2022-03), p. 19-34
    Abstract: Despite the vast utility of polymeric nanocarriers in drug delivery, their promising role in formulating efficient transdermal drug delivery systems for managing various dis-eases has not been explored properly. Main text: Polymeric nanocarriers have increased the interest of researchers with respect to im-proving intradermal and transdermal delivery of drugs having ominous penetration and solubility issues. Therefore, a range of invasive and noninvasive approaches have been extensively explored in transdermal delivery systems for the safe and effective transportation of drugs across the skin into the systemic circulation. Accordingly, this review emphasizes the recently used, effectively appli-cable invasive and noninvasive methodologies for formulating transdermal systems in the form of polymeric films/patches, microneedles, and nanocarriers for better penetration and bioavailability. Conclusion: Various novel methodologies for transdermal drug delivery systems offer countless benefits over conventional methods, but still, a safe and effective delivery system is the major chal-lenge in terms of reproducible pharmacokinetic and pharmacodynamic results.
    Type of Medium: Online Resource
    ISSN: 2210-3031
    URL: Article
    DOI: 10.2174/2210303112666220107113135
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Effect of Quarantine and Recovery on Infectious Nodes in Wireless Sensor Network
    Bentham Science Publishers Ltd. ; 2018
    In:  International Journal of Sensors, Wireless Communications and Control Vol. 8, No. 1 ( 2018-08-10), p. 26-36
    Details
    In: International Journal of Sensors, Wireless Communications and Control, Bentham Science Publishers Ltd., Vol. 8, No. 1 ( 2018-08-10), p. 26-36
    Type of Medium: Online Resource
    ISSN: 2210-3279
    URL: Article
    DOI: 10.2174/2210327908666180413154130
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2018
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  • 8
    Online Resource
    Online Resource
    A Detailed Survey and Comparative Study of Cooperative Caching Methods for Mobile Ad Hoc Networks
    Bentham Science Publishers Ltd. ; 2019
    In:  International Journal of Sensors, Wireless Communications and Control Vol. 9, No. 3 ( 2019-07-30), p. 314-329
    Details
    In: International Journal of Sensors, Wireless Communications and Control, Bentham Science Publishers Ltd., Vol. 9, No. 3 ( 2019-07-30), p. 314-329
    Abstract: Mobile Ad Hoc Networks (MANETs) are networks that enable server and clients to impart without any settled foundation. MANET is a quickly developing region of research as it discovers use in different applications. In MANETs, network parceling and the fizzling of a mobile node because of weariness of their battery power can significantly diminish data accessibility. Data caching on the client is generally observed as a successful answer for enhancing data availability. Specifically, cooperative caching based on information sharing and coordination of cached data item among numerous clients is much time-consuming. Various cooperative caching plans have been proposed in the ongoing years. This paper examines the highlights for outlining a good cooperative cache management, and it overviews the current cooperative caching scheme. The paper likewise gives a correlation of the cooperative caching scheme and examines open doors for future research work.
    Type of Medium: Online Resource
    ISSN: 2210-3279
    URL: Article
    DOI: 10.2174/2210327908666181120103838
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2019
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  • 9
    Online Resource
    Online Resource
    4-aryl/heteroaryl-4H-fused Pyrans as Anti-proliferative Agents: Design, Synthesis and Biological Evaluation
    Bentham Science Publishers Ltd. ; 2018
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 18, No. 1 ( 2018-03-16), p. 57-73
    Details
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 18, No. 1 ( 2018-03-16), p. 57-73
    Abstract: The current study is focused on the design and synthesis of 4-aryl/heteroaryl-4H-fused pyrans as anti-proliferative agents. All the synthesized molecules were screened against a panel of human carcinoma cell lines. Description: Significant inhibition was exhibited by the compounds against HCT-116 (Colon) and PC-3 (Prostate) cell lines while A-549 (Lung) cell lines, MiaPaCa-2 (Pancreatic) cell lines and HL-60 (Leukemia Cancer) cell lines were almost resistant to the exposure of the test compounds. Compound FP-(v)n displayed noteworthy cytotoxicity towards HCT-116 malignant cells with the IC50 value of 0.67 µM. It induces apoptosis as revealed by several biological endpoints like apoptotic body formation, through DAPI staining, phase contrast microscopy and mitochondrial membrane potential loss. Moreover FP-(v)n is a potent apoptotic inducer confirmed by cell cycle arrest and ROS generation. The cell phase distribution studies indicate an augment from 4.94 % (control sample) to 39.68 % (sample treated with 1.5 µM compound FP-(v)n) in the apoptotic population. Compound FP-(v)n inhibits the tumor growth in Ehrlich ascites carcinoma (EAC), Ehrlich Tumor (ET, solid) and sarcoma-180 (solid) mice models. Additionally, it was established to be non-toxic at maximum tolerated dose of 1000 mg/kg in acute oral toxicity in Swiss-albino mice. Conclusion: The current study provides an insight into anti-cancer potential of FP-(v)n, which might be valuable in the treatment of tumor.
    Type of Medium: Online Resource
    ISSN: 1871-5206
    URL: Article
    DOI: 10.2174/1871520617666170918143911
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2018
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    EBPA: A Novel Framework for the Analysis of Process Performance on the Basis of Real-Time NASA Application
    Bentham Science Publishers Ltd. ; 2021
    In:  Recent Advances in Computer Science and Communications Vol. 14, No. 2 ( 2021-05-20), p. 647-654
    Details
    In: Recent Advances in Computer Science and Communications, Bentham Science Publishers Ltd., Vol. 14, No. 2 ( 2021-05-20), p. 647-654
    Abstract: Workflow extraction is the connecting link between process modelling and data mining. Extraction of information and make insight from it using event log is the primary objective of workflow mining. The learning got along these logs can build comprehension about the workflow of procedures and association of different processes. That can help with upgrading them if necessary. Objective: The aim of this paper is to display a process performance based framework where we compare reference model with extracted model (from a large information system) on the basis of key performance indices. Methods: Proposed approach perform extraction of workflow model using workflow mining. This process is effective and efficient as compare with building work flow model from scratch. This shows a logic about how to program event log data gathered from different sensors (Internet of Events). How we process and investigates to handle and propel the item work process by using the course of action. Results: Proposed approach displays a process based framework for the legacy system that ensures the effective and efficient working. So that accordingly extracted model behave like referenced model and results are validated by Key Performance Indices (KPI) for evaluating process performance. Conclusion: In this experimental data centric approach, our progressing work is to research a metric to quantify the nature of reference models and extracted model. On the basis of metric values, we take the decision on legacy information system process management.
    Type of Medium: Online Resource
    ISSN: 2666-2558
    URL: Article
    DOI: 10.2174/2213275912666190819111048
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
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