In:
Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 9 ( 2023-08), p. 1137-1150
Abstract:
Glucose, amino acids, and free fatty acids are critical nutrients participating in stimulating
or regulating the hormone secretion of islets. These nutrients are believed to be metabolized by pancreatic endocrine cells to function. However, recent evidence suggests that taste
receptors, which play key roles in the oral cavity to sense glucose (sweet taste), amino acids (umami taste), and free fatty acids (fatty taste), are expressed in pancreatic islet cells and may
act to sense these nutrients to regulate pancreatic hormone secretion, including insulin and glucagon. Disorders in these taste receptor pathways in islets may contribute to the pathogenesis
of diabetes, or it may influence hyperglycemia, disturbance in amino acid metabolism, or hyperlipidemia. In this review, we su mMarize the expression and hormone-regulating functions
of sweet, umami, and fatty taste receptors acting as nutrient sensors in pancreatic islets in vitro and in vivo. We discuss the potential roles of these taste receptor-nutrient sensor pathways in
islets targeted to develop therapeutic strategies for diabetes and related disease.
Type of Medium:
Online Resource
ISSN:
1871-5303
DOI:
10.2174/1871530323666221229115230
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2023
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