In:
The Open Orthopaedics Journal, Bentham Science Publishers Ltd., Vol. 7, No. 1 ( 2013-11-3), p. 624-629
Abstract:
Beta tricalciumphosphate pellets loaded with individualized antibiotics may represent novel options in the treatment of osteomyelitis and infectious bone disease. Here, the in vitro antibiotic elution of vancomycin and gentamicin from the synthetic bone graft substitutes Cerasorb ® and Cerasorb M ® was tested. Methods: Antibiotic elution and concentration of gentamcin and vancomycin were measured using photometrically-based measurement and homogeneous particle-enhanced turbidimetric inhibition immunoassays (PETINIA). Results: Initially both materials showed a high release of the loaded antibiotics, with Cerasorb M ® showing lower release levels for gentamicin and vancomycin than Cerasorb ® . Gentamicin concentrations of Cerasorb M granules and Cerasorb were below the minimum detectiontreshold until day four and six of the experiment respectively. The vancomycin release-level followed a similar pattern, although the vancomycin concentration eluted by Cerasorb M ® granules stayed above the detection threshold during the experimental time. Conclusions: Cerasorb ® and Cersorb M ® may represent a new treatment option in osteomyelitis and infectious bone disease.
Type of Medium:
Online Resource
ISSN:
1874-3250
DOI:
10.2174/1874325001307010624
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2013
detail.hit.zdb_id:
2395994-0
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