In:
Current Drug Delivery, Bentham Science Publishers Ltd., Vol. 18, No. 9 ( 2021-12-30), p. 1303-1313
Abstract:
A capsaicin cream was formulated by optimizing the rheological stability,
the release behavior of the drug, and the pharmacological effect. Objectives:: This study aimed to: (a) apply the Design of Experiment approach to study the rheological
stability and release behaviors of a drug (capsaicin) from a formulated oil-in-water cream and (b) investigate the skin irritation and anti-inflammatory and analgesic effects of the optimized
cream. Methods:: The cream prepared by the emulsification method was optimized using the central composite
design, and then the pharmacological effect in experimental animals was determined using Complete Freund's adjuvant (CFA). Results:: The effects of a permeation enhancer (X1), Vaseline (X2), and surfactants (X3) on the fluctuation
of the ratio of the viscous modulus (G ') to elastic modulus (G') (tan δ) after three cycles of cooling-heating (10-40°C), flux, and skin deposition of capsaicin after 8 h on mouse skin were statistically
analyzed and optimized. The final obtained CAP-cream did not cause irritation in the rabbit model and produced comparable anti-inflammatory and analgesic effects to the reference product
(Voltaren® emulgel). Conclusions:: This study successfully integrated the DoE approach, rheological science, and pharmacological
studies to develop a stable and highly effective semi-solid product containing capsaicin.
Type of Medium:
Online Resource
ISSN:
1567-2018
DOI:
10.2174/1567201818999210120201006
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
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