In:
Current Cardiology Reviews, Bentham Science Publishers Ltd., Vol. 16, No. 3 ( 2020-09-10), p. 178-186
Abstract:
Cardiovascular Disease (CVD) in Systemic Lupus Erythematosus (SLE) and Neuropsychiatric
SLE (NPSLE) has an estimated prevalence of 50% and 40%, respectively and both constitute major causes of death among SLE patients. In this review, a combined brain/heart Magnetic
Resonance Imaging (MRI) for SLE risk stratification has been proposed. : The pathophysiologic background of NPSLE includes microangiopathy, macroscopic infarcts and
accelerated atherosclerosis. Classic brain MRI findings demonstrate lesions suggestive of NPSLE in 50% of the NPSLE cases, while advanced MRI indices can detect pre-clinical lesions in the majority
of them, but their clinical impact still remains unknown. Cardiac involvement in SLE includes myo-pericarditis, valvular disease/endocarditis, Heart Failure (HF), coronary macro-microvascular
disease, vasculitis and pulmonary hypertension. Classic and advanced Cardiovascular Magnetic Resonance (CMR) indices allow function and tissue characterization for early diagnosis
and treatment follow-up of CVD in SLE. : Although currently, there are no clinical data supporting the combined use of brain/heart MRI in
asymptomatic SLE, it may have a place in cases with clinical suspicion of brain/heart involvement, especially in patients at high risk for CVD/stroke such as SLE with antiphospholipid syndrome
(SLE/APS), in whom concurrent cardiac and brain lesions have been identified. Furthermore, it may be of value in SLE with multi-organ involvement, NPSLE with concurrent cardiac involvement,
and recent onset of arrhythmia and/or heart failure.
Type of Medium:
Online Resource
ISSN:
1573-403X
DOI:
10.2174/1573403X15666190801122105
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2020
detail.hit.zdb_id:
2216911-8
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