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  • Bentham Science Publishers Ltd.  (5)
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  • Bentham Science Publishers Ltd.  (5)
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  • 1
    Online Resource
    Online Resource
    A Case with Atypical Clinical Course Diagnosed as Osteoarthritis, Osteonecrosis, Subchondral Insufficiency Fracture, or Rapidly Destructive Coxopathy
    Bentham Science Publishers Ltd. ; 2014
    In:  The Open Rheumatology Journal Vol. 8, No. 1 ( 2014-9-12), p. 20-23
    Details
    In: The Open Rheumatology Journal, Bentham Science Publishers Ltd., Vol. 8, No. 1 ( 2014-9-12), p. 20-23
    Abstract: Osteonecrosis (ON), subchondral insufficiency fracture (SIF), and rapidly destructive coxopathy (RDC) are considered to be clinically different disorders despite exhibiting several overlapping features. We encountered an elderly female patient with an atypical clinical course who was radiographically diagnosed as having osteoarthritis (OA), ON, SIF, and/or RDC over a long-term follow-up. In this case, radiographic diagnosis was apparently affected by the timing of imaging evaluation and was challenging because of radiographic overlap and atypical disease progression. The disorders of OA, SIF, ON, and RDC might share a similar pathophysiology.
    Type of Medium: Online Resource
    ISSN: 1874-3129
    URL: Article
    DOI: 10.2174/1874312901408010020
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2395999-X
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Anti-Nociceptive Effects of Elcatonin Injection for Postmenopausal Women with Back Pain: A Randomized Controlled Trial
    Bentham Science Publishers Ltd. ; 2010
    In:  The Open Orthopaedics Journal Vol. 4, No. 1 ( 2010-3-4), p. 132-136
    Details
    In: The Open Orthopaedics Journal, Bentham Science Publishers Ltd., Vol. 4, No. 1 ( 2010-3-4), p. 132-136
    Abstract: Eel calcitonin (elcatonin) injection is widely used for elderly patients suffering from somatic pain in Japan. However, there have been few reports on the analgesic effects of elcatonin injection. The purpose of this study was to examine the analgesic effects of elcatonin injection in postmenopausal women with lower back pain. Methods: This study was designed as a double-blind, randomized, placebo-controlled study. Thirty-six women aged ≥50 years with acute lower back pain participated in this study. They were randomly divided into two treatment groups according to whether they received a placebo or a weekly trigger point injection of elcatonin (20 units). They were observed for 5 weeks and the extent of pain at motion and at rest according to the visual analog scale (VAS) was evaluated. The mean VAS scores for the elcatonin group were then compared with those of the placebo group. Results: There were no statistically significant differences in the mean VAS scores for pain at rest between the two groups during the 5-week treatment course. However, the mean VAS scores for motion pain in the elcatonin group were significantly lower than those in the placebo group at the third, fifth and sixth weeks. Conclusions: Elcatonin injection (20 units) significantly relieved motion pain in the lower back in postmenopausal women after three weeks of treatment. This analgesic effect continued for the subsequent 3 weeks.
    Type of Medium: Online Resource
    ISSN: 1874-3250
    URL: Article
    DOI: 10.2174/1874325001004010132
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2010
    detail.hit.zdb_id: 2395994-0
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Joint Pain Undergoes a Transition in Accordance with Signal Changes of Bones Detected by MRI in Hip Osteoarthritis
    Bentham Science Publishers Ltd. ; 2013
    In:  The Open Rheumatology Journal Vol. 7, No. 1 ( 2013-9-30), p. 67-74
    Details
    In: The Open Rheumatology Journal, Bentham Science Publishers Ltd., Vol. 7, No. 1 ( 2013-9-30), p. 67-74
    Abstract: In this study, we aimed to investigate whether joint pain is derived from cartilage or bone alterations. Methods: We reviewed 23 hip joints of 21 patients with primary hip osteoarthritis (OA), which were classified into Kellgren–Laurence (KL) grading I to IV. Plain radiographs and magnetic resonance imaging (MRI) were obtained from all of the 23 joints. Two of the 21 patients had bilateral hip OA. Pain was assessed based on the pain scale of Denis. A Welch t test was performed for age, height, weight, body mass index, bone mineral density, and a Mann–Whitney U test was performed for KL grading. Results: Four of 8 hip joints with pain and OA showed broad signal changes detected by MRI. Fourteen hip joints without pain, but with OA did not show broad signal changes by MRI. Collectively, MRI analyses showed that broad signal changes in OA cases without joint pain or with a slight degree of joint pain were not observed, while broad signal changes were observed in OA cases with deteriorated joint pain. Conclusion: Our findings suggest that hip joint pain might be associated with bone signal alterations in the hips of OA patients.
    Type of Medium: Online Resource
    ISSN: 1874-3129
    URL: Article
    DOI: 10.2174/1874312920130823002
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2013
    detail.hit.zdb_id: 2395999-X
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  • 4
    Online Resource
    Online Resource
    The Pathophysiology and Progression of Hip Osteoarthritis Accompanied with Joint Pain are Potentially Due to Bone Alterations - Follow-up Study of Hip OA Patients
    Bentham Science Publishers Ltd. ; 2014
    In:  The Open Rheumatology Journal Vol. 8, No. 1 ( 2014-10-2), p. 46-53
    Details
    In: The Open Rheumatology Journal, Bentham Science Publishers Ltd., Vol. 8, No. 1 ( 2014-10-2), p. 46-53
    Abstract: This study examined hip osteoarthritis (OA) patients with joint pain and accompanying signal changes detected by magnetic resonance imaging (MRI). Methods : A total of 19 hip OA patients with suddenly occurring or worsening pain regardless of Kellgren-Lawrence grading were enrolled. The patients were monitored using MRI, plain radiographs, and the Denis pain scale for a minimum of 6 months. The patients were classified into 2 groups: those whose pain improved during conservative treatment (Group A) and those whose pain persisted (Group B). Results : Joint pain disappeared or was markedly improved in all 10 cases in Group A. Radiographic OA progression occurred in 7 of 8 cases with available radiographs. Hip MRI was performed on 7 of 10 patients, among whom bone signal changes disappeared in 6 patients. One patient exhibited persisting bone signal alterations although joint pain had completely disappeared. In Group B, joint pain remained in all 9 cases. Radiographic OA progression occurred in 8 of 9 cases, and local (4 cases) or broad (5 cases) bone signal alterations were present in end-point MRI examinations. Two patients exhibited different regional MRI bone signal changes (local or broad) at the end of follow-up. The mean age of Group B was significantly higher than that of Group A. Conclusion : This study uncovered the following observations: 1) hip OA with joint pain had bone alterations that were detectable by MRI, 2) these bone alterations disappeared when joint pain improved, 3) bone alterations remained when joint pain continued, and 4) radiographic OA progressed to a more advanced stage over a short time period. These findings indicate that the pathophysiology of OA, joint pain, and OA progression may primarily be due to bone changes.
    Type of Medium: Online Resource
    ISSN: 1874-3129
    URL: Article
    DOI: 10.2174/1874312901408010046
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2395999-X
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  • 5
    Online Resource
    Online Resource
    The Pathophysiology of Primary Hip Osteoarthritis may Originate from Bone Alterations
    Bentham Science Publishers Ltd. ; 2013
    In:  The Open Rheumatology Journal Vol. 7, No. 1 ( 2013-11-29), p. 112-118
    Details
    In: The Open Rheumatology Journal, Bentham Science Publishers Ltd., Vol. 7, No. 1 ( 2013-11-29), p. 112-118
    Abstract: The aim of this study was to investigate whether bone alterations detected by hip magnetic resonance imaging (MRI) were associated with subsequent primary hip OA. Methods: We enrolled 7 patients with hip joint pain from their first visit, at which hip joints were classified as grade 0 or I on the Kellgren-Lawrence grading scale. Plain radiographs and magnetic resonance imaging (MRI) were performed on all cases, and pain was assessed with the Denis pain scale. Average age, height, weight, body mass index, bone mineral density (L1-4), central edge angle, Sharp’s angle, and acetabular hip index were calculated. Results: Within two months of the onset of pain, 4 of the 7 cases showed broad bone signal changes, while 3 cases showed local signal changes in the proximal femur on hip MRI. Three to 6 months after the onset of pain, in all patients whose pain was much improved, plain radiographs showed progression to further-stage OA. Conclusion: Our findings suggest that bone abnormalities in the proximal femur might be involved in the pathogenesis of primary hip OA.
    Type of Medium: Online Resource
    ISSN: 1874-3129
    URL: Article
    DOI: 10.2174/1874312920130930003
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2013
    detail.hit.zdb_id: 2395999-X
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    Online Resource
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