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  • 1
    Online Resource
    Online Resource
    A Review on Hyphenated Techniques in Analytical Chemistry
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Analytical Chemistry Vol. 18, No. 9 ( 2022-11), p. 956-976
    Details
    In: Current Analytical Chemistry, Bentham Science Publishers Ltd., Vol. 18, No. 9 ( 2022-11), p. 956-976
    Abstract: In chemical and pharmaceutical analysis, hyphenated techniques range from the combinations involving separation-separation, separation-identification and identification-identification techniques and are widely used nowadays, as they hold many advantages like fast accurate analysis, a higher degree of automation, higher sample throughput, better reproducibility, specificity and sensitivity. They also reduce contamination due to closed systems and offer simultaneous separation and quantification, leading to better analysis. Objective: Though many reviews have appeared on hyphenated analytical techniques till date, in the past decade, their use has increased manifold and therefore, we thought it imperative to review the latest progress in this field. In the present article, an attempt has been made to cover the latest information on various hyphenated techniques like LC-MS (Liquid Chromatography-Mass Spectroscopy), GC-MS (Gas Chromatography-Mass Spectroscopy), LC-IR (Liquid Chromatography-Infra-Red Spectroscopy), as well as, LC-MS-MS (Liquid Chromatography-Mass Spectroscopy-Mass Spectroscopy), LC-NMR-MS (Liquid Chromatography-Nuclear Magnetic Resonance-Mass Spectroscopy), etc. Conclusion: This review describes a total of seventeen different hyphenated techniques, comprising mainly of the combinations of chromatographic techniques with spectroscopic techniques. We have tried to cover the latest information on various double hyphenated techniques like LC-MS , LC-NMR, LC-IR, HPTLC-MS, HPTLC-IR, GC-MS, GC-IR, GC-TLC, GC-AES, MS-MS, CE-MS, GC-NMR, as well as, triple hyphenated techniques like LC-MS-MS, LC-NMR-MS, LC-UV-MS, GC-MS-MS, GC-IR-MS. Mainly the principle, instrumentation, applications, and advantages of each of the techniques are discussed in this review. Also, disadvantages of a few techniques have been mentioned.
    Type of Medium: Online Resource
    ISSN: 1573-4110
    URL: Article
    DOI: 10.2174/1573411018666220818103236
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    3D-QSAR and Molecular Docking Studies on Oxadiazole Substituted Benzimidazole Derivatives: Validation of Experimental Inhibitory Potencies Towards COX-2
    Bentham Science Publishers Ltd. ; 2019
    In:  Current Computer-Aided Drug Design Vol. 15, No. 4 ( 2019-07-01), p. 277-293
    Details
    In: Current Computer-Aided Drug Design, Bentham Science Publishers Ltd., Vol. 15, No. 4 ( 2019-07-01), p. 277-293
    Abstract: In past few decades, computational chemistry has seen significant advancements in design and development of novel therapeutics. Benzimidazole derivatives showed promising anti-inflammatory activity through the inhibition of COX-2 enzyme. Objective: The structural features necessary for COX-2 inhibitory activity for a series of oxadiazole substituted benzimidazoles were explored through 3D-QSAR, combinatorial library generation (Combi Lab) and molecular docking. Methods: 3D-QSAR (using kNN-MFA (SW-FB) and PLSR (GA) methods) and Combi Lab studies were performed by using VLife MDS Molecular Design Suite. The molecular docking study was performed by using AutoDockVina. Results: Significant QSAR models generated by PLSR exhibited r2 = 0.79, q2 = 0.68 and pred_r2 = 0. 84 values whereas kNN showed q2 = 0.71 and pred_r2 = 0.84. External validation of developed models by various parameters assures their reliability and predictive efficacy. A library of 72 compounds was generated by combinatorial technique in which 11 compounds (A1-A5 and B1-B6) showed better predicted biological activity than the most active compound 27 (pIC50 = 7.22) from the dataset. These compounds showed proximal interaction with amino acid residues like TYR355 and/or ARG120 on COX-2(PDB ID: 4RS0). Conclusion: The present work resulted in the design of more potent benzimidazoles as COX-2 inhibitors with good interaction as compared to reference ligand. The results of the study may be helpful in the development of novel COX-2 inhibitors for inflammatory disorders.
    Type of Medium: Online Resource
    ISSN: 1573-4099
    URL: Article
    DOI: 10.2174/1573409914666181003153249
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2019
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Promises of Molecular Pharmaceutics in the Development of Novel Drug Delivery Formulations
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Drug Delivery Vol. 20, No. 9 ( 2023-11), p. 1262-1274
    Details
    In: Current Drug Delivery, Bentham Science Publishers Ltd., Vol. 20, No. 9 ( 2023-11), p. 1262-1274
    Abstract: Molecular pharmaceutics play a critical role in the drug delivery system, representing the direct interconnection of drug bioavailability with its molecular form. There is a diversity in the molecular structures by which it affects its properties, such as amorphous form, crystalline form, partialamorphous molecular dispersion, and disordered state. The active pharmaceutical ingredient (API) and the excipients utilized in the formulation process contain various divergent modes used in the formulation process. They include better formulations of any type to obtain good quality pharmaceutical products. This review reveals how the molecular states affect the API and are important in maintaining the quality of dosage forms. Furthermore, the physio-chemical properties of the components and various pharmaceutical approaches employed in the formulation of dosage forms are studied from the point of view of molecular pharmaceutics.
    Type of Medium: Online Resource
    ISSN: 1567-2018
    URL: Article
    DOI: 10.2174/1567201820666221114113637
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Promising Repurposed Antiviral Molecules to Combat SARS-CoV-2: A Review
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Pharmaceutical Biotechnology Vol. 24, No. 14 ( 2023-11), p. 1727-1739
    Details
    In: Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 24, No. 14 ( 2023-11), p. 1727-1739
    Abstract: COVID-19, an extremely transmissible and pathogenic viral disease, triggered a global pandemic that claimed lives worldwide. To date, there is no clear and fully effective treatment for COVID-19 disease. Nevertheless, the urgency to discover treatments that can turn the tide has led to the development of a variety of preclinical drugs that are potential candidates for probative results. Although most of these supplementary drugs are constantly being tested in clinical trials against COVID-19, recognized organizations have aimed to outline the prospects in which their use could be considered. A narrative assessment of current articles on COVID-19 disease and its therapeutic regulation was performed. This review outlines the use of various potential treatments against SARS-CoV-2, categorized as fusion inhibitors, protease inhibitors, and RNA-dependent RNA polymerase inhibitors, which include antiviral drugs such as Umifenovir, Baricitinib, Camostatmesylate, Nafamostatmesylate, Kaletra, Paxlovide, Darunavir, Atazanavir, Remdesivir, Molnupiravir, Favipiravir, and Ribavirin. To understand the virology of SARS-CoV-2, potential therapeutic approaches for the treatment of COVID-19 disease, synthetic methods of potent drug candidates, and their mechanisms of action have been addressed in this review. It intends to help readers approach the accessible statistics on the helpful treatment strategies for COVID-19 disease and to serve as a valuable resource for future research in this area.
    Type of Medium: Online Resource
    ISSN: 1389-2010
    URL: Article
    DOI: 10.2174/1389201024666230302113110
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Novel Second Generation HIV Integrase Inhibitor-DOLUTEGRAVIR: An Emerging Weapon Against HIV
    Bentham Science Publishers Ltd. ; 2017
    In:  Letters in Drug Design & Discovery Vol. 14, No. 3 ( 2017-01-26), p. 354-371
    Details
    In: Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 14, No. 3 ( 2017-01-26), p. 354-371
    Type of Medium: Online Resource
    ISSN: 1570-1808
    URL: Article
    DOI: 10.2174/1570180813666160909121751
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2017
    SSG: 15,3
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  • 6
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    Online Resource
    A scoping review on recent progress on purpurin and its derivatives
    Bentham Science Publishers Ltd. ; 2023
    In:  Letters in Drug Design & Discovery Vol. 20 ( 2023-02-20)
    Details
    In: Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 20 ( 2023-02-20)
    Abstract: Purpurin is being used as a red dye for many decades. But recently, due to its pharmacological properties, purpurin and its derivatives have attracted a lot of researchers for the treatment of various ailments, such as cancer, Alzheimer’s disease, depression, etc. Objectives: The objective of this study is to provide an overview of its pharmacological properties, pharmacokinetic studies, synthesis, isolation, quality assurance, and patent studies. Method: A systemic scoping review was undertaken. Three databases (Pubmed, Scopus, and Google Scholar) and patent websites were searched using relevant words (e.g., purpurin, purpurin derivatives, anticancer, toxicity, etc.). All outcomes for studies that met the inclusion criteria were included in the review. Extracted data were accumulated using tables, figures, and accompanying narrative descriptive summaries. The review was reported using the preferred reporting items for scoping review (PRISMA-ScR) guidelines. Sixty-eight studies and eighty-six patents met the inclusion criteria, mostly preclinical (in vitro, in vivo, and in silico) studies performed in rats, mice, dogs, and zebrafish, followed by one clinical trial study. Results: The potent antioxidant nature of purpurin is the main reason behind its vast pharmacological properties. It acts by decreasing mitochondrial stress and by acting on the endoplasmic reticulum. It also crosses the BBB barrier, has high GI absorption, and follows the Lipinski rule, which makes it a good drug for various neurodegenerative disorders. It inhibits various CYP-450, CYP 1A2, and CYP 3A4 enzymes, which are responsible for causing mutations. It gets photosensitized by UV light and causes ROS-dependent apoptosis in cancer cells. Conclusion: This scoping review highlights purpurin and its derivatives as highly prized moieties in the treatment of various neurological conditions and cancer. The unique nature of purpurin is responsible for its pharmacological properties, which are due to the presence of hydroxyl and keto groups at specific positions. It gets photosensitized by UV and laser light and acts as an anticancer drug. But the lack of robust evaluation in clinical studies is another major concern. Purpurin can be seen in the prescription in the future, although a lot of work still needs to be done.
    Type of Medium: Online Resource
    ISSN: 1570-1808
    URL: Article
    DOI: 10.2174/1570180820666230220124204
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Overview of the Current Advancements and Trends in the Transungual Drug Delivery System
    Bentham Science Publishers Ltd. ; 2023
    In:  Letters in Drug Design & Discovery Vol. 20 ( 2023-03-06)
    Details
    In: Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 20 ( 2023-03-06)
    Abstract: Drug delivery across human nails is termed a transungual drug delivery system. It is recommended for the amelioration of nail disorders and infectious nail diseases like onychomycosis. Thereby, vivid anti-fungal regimens have been prescribed in the form of different types of formulations, including nail lacquers, nail film, nail paint, and other types for treating onychomycosis. Method: All the formulations currently marketed or being marketed for the transungal drug delivery system were thoroughly studied, compared, and evaluated for their advantages and disadvantages so that a new vision can be sustained along the path of creating newer anti-fungal transunguals, keeping in mind the anatomy of the nail and various parameters that govern bioavailability of active pharmaceutical ingredients across the nail bed. Accordingly, different techniques are devised to enhance permeation across the nail. The various parameters used to evaluate these formulations depend upon their physical, chemical, and mechanical properties. Conclusion: The recent approaches in transungual novel drug delivery systems have been reported while exemplifying a few patented and marketed formulations, along with the clinical trial status of these formulations. There is a need for the development of new techniques to overcome all the loopholes present in the ongoing treatment techniques and the formulations used nowadays for the treatments of diseases that occur in nails. After thoroughly detailing transungal novel drug delivery systems, we envisage great opportunities for the researchers to carry out novel work in chemotherapy through nails.
    Type of Medium: Online Resource
    ISSN: 1570-1808
    URL: Article
    DOI: 10.2174/1570180820666230306140637
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 8
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    Online Resource
    Green synthetic strategies and pharmaceutical applications of thiazine and its derivatives: An updated review
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Pharmaceutical Biotechnology Vol. 25 ( 2023-09-08)
    Details
    In: Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 25 ( 2023-09-08)
    Abstract: Thiazines are a sizable class of organic heterocycles that are notable for their skeletal versatility and relative chemical simplicity, making them among the most flexible sources of biologically active compounds. The term "green synthesis" refers to implementing energy-efficient procedures for the nature-friendly production of materials and chemicals using green solvents, catalysts, and suitable reaction conditions.Considering the importance of green chemistry and the outstanding therapeutic profile of thiazines, the present work was designed to review the recent advances in green chemistry-based synthetic strategies of thiazine and its derivatives. The green synthetic approaches, including microwave-assisted, ultrasound-assisted, and various other synthetic methods for thiazine and its derivatives, were discussed and generalized. In addition, applications of thiazine and its derivatives in pharmaceutical sciences were explained with examples of marketed drugs.The discussed sustainable synthetic methods for thiazines and their derivatives could be useful in developing other medicinally important lead molecules. They could also aid in developing new synthetic schemes and apparatuses that may simplify chemical manufacturing processes and enable novel reactions with minimal by-products while questing for optimal, green solvents. This review can help anyone interested in this fascinating class of heterocycles to make decisions about selecting targets and tasks for future research.
    Type of Medium: Online Resource
    ISSN: 1389-2010
    URL: Article
    DOI: 10.2174/1389201025666230908141543
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Role of Animal Models in Parkinson's Disease (PD): What Role They Play in Preclinical Translational Research
    Bentham Science Publishers Ltd. ; 2024
    In:  CNS & Neurological Disorders - Drug Targets Vol. 23, No. 2 ( 2024-02), p. 181-202
    Details
    In: CNS & Neurological Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 23, No. 2 ( 2024-02), p. 181-202
    Abstract: Animal models for drug discovery and development in Parkinson ’s disease have played an important role in the characterization of the pathophysiology of diseases and associated mechanisms of injury, drug target identification, and evaluation of novel therapeutic agents for toxicity/ safety, pharmacokinetics, pharmacodynamics, and efficacy. Objective: The review is intended to reform the scope, advantages, and limitations of various Parkinson’s Disease models and their scope in translational research. The lack of a gold standard for PD animal models presents a major challenge in devising a validation system. This review is an attempt to provide a way to adopt the validation approach for PD animal model for research. Methods: Because underlying disease mechanisms are so similar across species, it is possible to extrapolate results from Parkinson's disease studies using animal models. Furthermore, behavioural tests used to access the neurobehavioral test with its limitations were explored for rodents, non-human primates, lower-order animals, and invertebrates. The role of gender selectivity and non-selectivity is the one major concern in PD model validation that is addressed in the review. Results: The rigorous validation has been done on animal models for Parkinson's disease (PD) based on comparisons to the human state. Regarding toxicological and safety investigations in PD, non-animal options must be thoroughly validated. There are both advantages and disadvantages to using animal models of Parkinson's disease as proof-of-concept research. Conclusion: The specific animal model selected for a given drug to be tested and developed depends on the goal of the specific study.
    Type of Medium: Online Resource
    ISSN: 1871-5273
    URL: Article
    DOI: 10.2174/1871527322666230223150347
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2024
    SSG: 15,3
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