In:
Current Protein & Peptide Science, Bentham Science Publishers Ltd., Vol. 20, No. 12 ( 2019-12-16), p. 1204-1217
Abstract:
Legume proteins are precursors of bioactive components, such as peptides. In the present paper,
different types of legume as sources of bioactive peptides and hydrolysates are considered and discussed based on their anti-inflammatory effect. Peptides with anti-inflammatory activity were included
from in vitro and in vivo studies. Current strategies for obtaining bioactive peptides, as well as their structure and impact on health, were also reviewed. It was discovered that peptides derived from legume
protein, mainly soybean and bean, can regulate several inflammatory markers, which include prostaglandin E2 (PGE2), nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-
2), cytokines, and chemokines. So far, lunasin, VPY and γ-glutamyl peptides have been identified with anti-inflammatory activity but their mechanisms have not been fully elucidated. Furthermore, it is necessary
to gather more information about hydrolysates containing peptides and single peptides with antiinflammatory activity. Considering the wide diversity, legume may be promising components to produce
peptides efficient to ameliorate inflammatory disorders.
Type of Medium:
Online Resource
ISSN:
1389-2037
DOI:
10.2174/1389203720666190430110647
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2019
SSG:
12
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