In:
The Open Neurology Journal, Bentham Science Publishers Ltd., Vol. 7, No. 1 ( 2013-5-3), p. 11-16
Abstract:
To estimate the quantity of multiple sclerosis (MS) patients with brain atrophy as indicated by third ventricular enlargement using transcranial colourcoded ultrasound (TCCS). Methods: The width of the 3. ventricle was assessed by TCCS in 70 healthy controls (male 31, female 39, mean age 41 ± 15 years, age range 18 – 79 years), and in a cohort of 54 patients with relapsing remitting MS (male 16, female 38, mean age 40 ± 10 years, median EDSS 2 [1-3]). Results: In the controls, the width of the 3. ventricle increased with age (without any sex differences) from 3.0 ± 0.76 mm in the age group 〈 40 years to 4.0 ± 0.74 mm in the age group of 60 years or more (ANOVA p=0.0001). Derived from regression analysis, the upper limit of the 95% Confidence Interval for each year provided cutoff points according to which 14 of 54 patients (25%) exhibited an enlarged 3. ventricle. In a multivariate regression analysis, the width of the 3. ventricle over all MS patients was significantly related to EDSS (Spearman rho , r=0.446, p 〈 0.005) and to MS duration (r=0.319, p 〈 0.005). Conclusions: Even in MS patients in good clinical conditions the rate of patients with brain atrophy determined by TCCS is high.
Type of Medium:
Online Resource
ISSN:
1874-205X
DOI:
10.2174/1874205X01307010011
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2013
detail.hit.zdb_id:
2395982-4
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