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  • Beilstein Institut  (2)
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  • Beilstein Institut  (2)
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  • 1
    Online Resource
    Online Resource
    Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells
    Beilstein Institut ; 2019
    In:  Beilstein Journal of Nanotechnology Vol. 10 ( 2019-09-24), p. 1933-1942
    Details
    In: Beilstein Journal of Nanotechnology, Beilstein Institut, Vol. 10 ( 2019-09-24), p. 1933-1942
    Abstract: Diosgenin (Di), a steroidal sapogenin derived from plants, has been shown to exert anticancer effects in preclinical studies. Using Di as a starting material, various Di derivatives were designed and synthesized, aiming to discover new steroid-based antitumor agents. In this work, we synthesized several Di derivatives and screened FZU-0021-194-P2 (P2), which showed more potent cytotoxic activities against human non-small-cell lung cancer A549 and PC9 cells. Considering that Di has a unique sterol structure similarly to cholesterol, P2 phytosomes (P2Ps) were prepared to further improve the water solubility of P2. The P2Ps exhibited a particle size of 53.6 ± 0.3 nm with oval shape and a zeta potential of −4.0 ± 0.7 mV. P2Ps could inhibit the proliferation of lung cancer cells more efficiently than Di phytosomes after 72 h of incubation time by inducing cell cycle arrest and apoptosis. The results indicated that P2Ps could be a promising anticancer formulation for non-small-cell lung cancer.
    Type of Medium: Online Resource
    ISSN: 2190-4286
    URL: Article
    DOI: 10.3762/bjnano.10.189
    Language: English
    Publisher: Beilstein Institut
    Publication Date: 2019
    detail.hit.zdb_id: 2583584-1
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  • 2
    Online Resource
    Online Resource
    Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction
    Beilstein Institut ; 2023
    In:  Beilstein Journal of Organic Chemistry Vol. 19 ( 2023-08-22), p. 1234-1242
    Details
    In: Beilstein Journal of Organic Chemistry, Beilstein Institut, Vol. 19 ( 2023-08-22), p. 1234-1242
    Abstract: A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds. The piperidine-promoted three-component reaction of ammonium acetate, isatins and the in situ-generated dimedone adducts of 3-ethoxycarbonylmethyleneoxindoles afforded mutlifunctionalized dispiro[indoline-3,2'-quinoline-3',3''-indoline] derivatives in good yields and with high diastereoselectivity. On the other hand, a similar reaction of the dimedone adducts of 3-phenacylideneoxindoles afforded unique dispiro[indoline-3,2'-pyrrole-3',3''-indoline] derivatives with a cyclohexanedione substituent. A plausible reaction mechanism is proposed to explain the formation of the different spirooxindoles.
    Type of Medium: Online Resource
    ISSN: 1860-5397
    URL: Article
    DOI: 10.3762/bjoc.19.91
    Language: English
    Publisher: Beilstein Institut
    Publication Date: 2023
    detail.hit.zdb_id: 2192461-2
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