In:
World Journal of Gastrointestinal Oncology, Baishideng Publishing Group Inc., Vol. 15, No. 9 ( 2023-9-15), p. 1662-1672
Abstract:
Pancreatic cancer (PanCa) presents a catastrophic disease with poor overall survival at advanced stages, with immediate requirement of new and effective treatment options. Besides genetic mutations, epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic target. Mechanisms beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under trails. Combinations of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa patients. Recent studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic therapies. Epigenetics thus promises to generate a significant amount of new knowledge of biological and medical importance. Our review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions, and novel pharmacological strategies that target these components could potentially lead to breakthroughs. We aim to highlight the possibilities that exist and the potential therapeutic interventions.
Type of Medium:
Online Resource
ISSN:
1948-5204
DOI:
10.4251/wjgo.v15.i9.1662
Language:
Unknown
Publisher:
Baishideng Publishing Group Inc.
Publication Date:
2023
detail.hit.zdb_id:
2573696-6
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