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  • Nature Publishing Group  (3)
  • BMJ Publishing  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Methyltetrahydrofolate is a potent and selective agonist for kainic acid receptors (1980)
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 852-853 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In membranes prepared from rat cerebellum13,3H-kainic acid labelled a single class of receptor sites having a dissociation constant (Kd) of 25 nM. Kainic acid and MTHF displaced 50 nM 3H-kainic acid from these sites with apparent inhibition constants (Xis) of 0.08 jjiM and 0.88 |xM, respectively ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/287852a0
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of Altitude on the Body/Venous Hæmatocrit Ratio (1962)
    [s.l.] : Nature Publishing Group
    Nature 194 (1962), S. 483-483 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Little is known of the constancy of the BH/VH ratio in varying physiological and pathological conditions. The ratio increases during pregnancy3, and in patients with splenomegaly4, and may decrease in congestive heart failure with fluid retention5. In subjects resident at an altitude of 5,740 ft. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/194483a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acetylcholinesterase and the Life-span of the Erythrocyte (1961)
    [s.l.] : Nature Publishing Group
    Nature 190 (1961), S. 1208-1209 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To determine whether normal levels of acetylcholinesterase are necessary for normal erythrocyte life-span, the enzyme was inhibited in vivo in five haematologically normal subjects by the administration of octamethylpyrophosphoramide (OMPA) 5 mgm. daily, and erythrocyte survival measured with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1901208a0
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    Paper (German National Licenses)
    Fulltext
  • 4
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    Feasibility of 2-D ultrasound shear wave elastography of fetal lungs in case of threatened preterm labour: a study protocol (2017)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2017-12-28
    Description: Introduction 2-D ultrasound shear wave elastography (SWE) could be considered as a new noninvasive tool for monitoring fetal lung development based on evaluation of mechanical properties during pregnancy. Interesting results are available concerning the use of SWE on developing organs, especially on premature infants and animal models. The main objective in this study is to evaluate the feasibility of 2-D SWE in human fetal lungs between 24 and 34 weeks of gestation (WG). The secondary objective is to modellise fetal lung-to-liver elastography ratio (LLE ratio) and to assess variations between normal lung and lung surfactant-enriched after a corticosteroids course indicated for a threatened preterm labour (TPL). Methods/design A prospective case-control study will be performed between 24 and 34 WG. Fetal lungs and liver will be explored by SWE into two groups: fetuses of women with an uncomplicated pregnancy (control group) and fetuses of women with a TPL requiring administration of corticosteroids (cases group). LLE ratio will be defined as the value of the lung elasticity divided by the value of the liver elasticity. Primary judgement criterion is the value of elasticity modulus expressed in kilopascal. Lungs and liver will be explored through three measurements to define the most reproducible regions with the lowest intra- and inter-observer variability. Feasibility will be evaluated by assessing the number of examinations performed and the number of examinations with interpretable results. Intra- and inter-observer reproducibility will be evaluated by means of the intra-class correlation coefficient. Ethics and dissemination Approval of the study protocol was obtained from the human ethical research committee (Comité de Protection des Personnes EST II, process number 15/494) and the French National Agency for Medicines and Health Products Safety (process number 2015-A01575-44). All participants will sign a statement of informed consent. Trial registration number NCT02870608 ; Recruiting.
    Keywords: Open access, Radiology and imaging
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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