In:
BMJ Open, BMJ, Vol. 14, No. 3 ( 2024-03), p. e078320-
Abstract:
The role of the Controlling Nutritional Status (CONUT) scores in predicting the prognosis of lymphoma cases has been extensively explored, with no consistent results. The present meta-analysis focused on accurately evaluating whether CONUT could be used to predict the prognosis of lymphoma cases and its clinicopathological value. Design The present meta-analysis was reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The prognostic significance of CONUT to overall survival (OS) and progression-free survival (PFS) in lymphoma was estimated by calculating pooled HRs with 95% CIs. The relationship between CONUT and clinicopathological characteristics was measured based on pooled ORs with 95% CIs. Data sources PubMed, Web of Science, Embase and Cochrane Library databases were comprehensively searched from inception through 24 March 2023. Statistical methods Either a random-effects model or a fixed-effects model was selected depending on the level of heterogeneity among the included studies. Results This meta-analysis enrolled seven articles, containing 2060 patients with lymphoma. According to the pooled analysis, a higher CONUT score significantly predicted poor OS (HR=1.94, 95% CI 1.46 to 2.57, p 〈 0.001) as well as poorer PFS (HR=1.51, 95% CI 1.04 to 2.20, p=0.031). Furthermore, according to the combined analysis, a higher CONUT score was significantly associated with Ann Arbor stages III–IV (OR=3.75, 95% CI 2.96 to 4.75, p 〈 0.001), an Eastern Cooperative Oncology Group performance status of 2–4 (OR=5.14, 95% CI 3.97 to 6.65, p 〈 0.001), high-intermediate/high National Comprehensive Cancer Network International Prognostic Index (OR=8.05, 95% CI 5.11 to 12.66, p 〈 0.001), B symptoms (OR=4.97, 95% CI 2.89 to 8.52, p 〈 0.001), extranodal disease (OR=3.25, 95% CI 2.24 to 4.70, p 〈 0.001), bone marrow involvement (OR=4.86, 95% CI 3.25 to 7.27, p 〈 0.001) and elevated lactate dehydrogenase levels (OR=3.21, 95% CI 2.37 to 4.34, p 〈 0.001). Conclusions According to our results, higher CONUT scores were significantly associated with poor OS and PFS in lymphoma.
Type of Medium:
Online Resource
ISSN:
2044-6055
,
2044-6055
DOI:
10.1136/bmjopen-2023-078320
DOI:
10.1136/bmjopen-2023-078320.supp1
DOI:
10.1136/bmjopen-2023-078320.supp4
DOI:
10.1136/bmjopen-2023-078320.supp2
DOI:
10.1136/bmjopen-2023-078320.supp5
DOI:
10.1136/bmjopen-2023-078320.supp6
DOI:
10.1136/bmjopen-2023-078320.supp7
DOI:
10.1136/bmjopen-2023-078320.supp3
Language:
English
Publisher:
BMJ
Publication Date:
2024
detail.hit.zdb_id:
2599832-8
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