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  • Annual Reviews  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    A PHYSIOLOGICAL VIEW OF THE PRIMARY CILIUM (2005)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 67 (2005), S. 515-529 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: The primary cilium, an organelle largely ignored by physiologists, functions both as a mechano-sensor and a chemo-sensor in renal tubular epithelia. This forgotten structure is critically involved in the determination of left-right sidedness during development and is a key factor in the development of polycystic kidney disease, as well as a number of other abnormalities. This review provides an update of our current understanding about the function of primary cilia. Much new information obtained in the past five years has been stimulated, in part, by discoveries of the primary cilium's key role in the genesis of polycystic kidney disease as well as its involvement in determination of left-right axis asymmetry. Here we focus on the various functions of the primary cilium rather than on its role in pathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.67.040403.101353
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ROUTES AND MECHANISM OF FLUID TRANSPORT BY EPITHELIA1 (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 60 (1998), S. 105-119 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Notes: Abstract The mechanism of fluid transport by leaky epithelia and the route taken by the transported fluid are in dispute. A consideration of current mathematical models for coupling of solutes and water, as well as the methodologies for the study of fluid transport, shows that local osmosis best accounts for water movement. Although it seems virtually certain that the tight junctions are water permeable, the fraction of absorbed fluid that crosses the tight junction cannot yet be determined with confidence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.physiol.60.1.105
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    Paper (German National Licenses)
    Fulltext
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