In:
Annual Review of Biomedical Data Science, Annual Reviews, Vol. 2, No. 1 ( 2019-07-20), p. 69-92
Abstract:
Connectivity mapping resources consist of signatures representing changes in cellular state following systematic small-molecule, disease, gene, or other form of perturbations. Such resources enable the characterization of signatures from novel perturbations based on similarity; provide a global view of the space of many themed perturbations; and allow the ability to predict cellular, tissue, and organismal phenotypes for perturbagens. A signature search engine enables hypothesis generation by finding connections between query signatures and the database of signatures. This framework has been used to identify connections between small molecules and their targets, to discover cell-specific responses to perturbations and ways to reverse disease expression states with small molecules, and to predict small-molecule mimickers for existing drugs. This review provides a historical perspective and the current state of connectivity mapping resources with a focus on both methodology and community implementations.
Type of Medium:
Online Resource
ISSN:
2574-3414
,
2574-3414
DOI:
10.1146/biodatasci.2019.2.issue-1
DOI:
10.1146/annurev-biodatasci-072018-021211
Language:
English
Publisher:
Annual Reviews
Publication Date:
2019
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