In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 61, No. 9 ( 2000-09-01), p. 1150-1155
Abstract:
Objective —To characterize healing of corneal epithelial
defects in horses and to evaluate the ability of epidermal growth factor (EGF) to modulate rate of
corneal epithelial healing in horses. Sample Population —20 eyes in 12 adult horses. Procedure —Corneal epithelial wounds were created
by mechanically debriding the limbus. Corneal healing was recorded for 3 treatment groups: 50 µg of
EGF/ml (n = 5 eyes), 5 µg of EGF/ml (7), and PBS solution (8). Corneal healing was recorded once daily after
instillation of fluorescein stain by use of photography and calculating the area of the wound, using imaging
software. Results —After corneal debridement, re-epithelialization
was rapid and progressed in a linear fashion for the first 5 to 7 days after surgery in all groups. After
that period, rates of healing decreased. A profound increase in the degree of inflammation, neovascularization,
melanosis, and scarring was observed in eyes treated with the high dose of EGF (50 µg/ml),
but there was not a statistical difference in mean healing time or in mean decrease in radius during the
linear phase between the control and either EGF treatment groups. However, for all 8 horses in which
both eyes were debrided, the first eye healed significantly faster than the second eye, regardless of
treatment. Conclusions and Clinical Relevance —Beneficial
effects of topical administration of a high dose of EGF for acceleration of healing of corneal defects in eyes
of horses are outweighed by the intensity of the associated inflammatory response. ( Am J Vet Res 2000;
61:1150–1155)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2000.61.1150
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2000
detail.hit.zdb_id:
2056942-7
SSG:
22
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