In:
The American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, Vol. 77, No. 3 ( 2007-09), p. 411-417
Abstract:
Negative consequences of malaria might account for seasonality in nutritional status in children in the Sahel. We report the impact of a randomized, double-blind, placebo-controlled trial of seasonal intermittent preventive anti-malarial treatment on growth and nutritional status in 1,063 Senegalese preschool children. A combination of artesunate and sulfadoxine-pyrimethamine was given monthly from September to November. In the intervention arm, mean weight gain was significantly greater (122.9 ± 340 versus 42.9 ± 344 [SD] g/mo, P 〈 0.0001) and losses in triceps and subscapular skinfold measurements were less (−0.39 ± 1.01 versus −0.66 ± 1.01 mm/mo, and −0.15 ± 0.64 versus −0.36 ± 0.62 mm/mo, respectively, P 〈 0.0001 for both). There was no difference in height increments. The prevalence of wasting increased significantly in the control arm (4.6% before versus 9.5% after, P 〈 0.0001), but remained constant in intervention children: 5.6% versus 7.0% ( P = 0.62). The prevention of malaria would improve child nutritional status in areas with seasonal transmission.
Type of Medium:
Online Resource
ISSN:
0002-9637
DOI:
10.4269/ajtmh.2007.77.411
Language:
Unknown
Publisher:
American Society of Tropical Medicine and Hygiene
Publication Date:
2007
detail.hit.zdb_id:
1491674-5
Permalink