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  • American Society of Hematology  (2)
  • 1
    Online Resource
    Online Resource
    Dietary Iron, Alcohol Consumption and Serum Ferritin Concentrations in African Americans.
    American Society of Hematology ; 2006
    In:  Blood Vol. 108, No. 11 ( 2006-11-16), p. 1551-1551
    Details
    In: Blood, American Society of Hematology, Vol. 108, No. 11 ( 2006-11-16), p. 1551-1551
    Abstract: We investigated the relationship of dietary iron and alcohol consumption with serum ferritin concentration among 143 inner-city African-Americans from the community. Seventy-one of the participants reported consuming an average of more than four alcoholic drinks per day and 72 less than two alcoholic drinks per week. The mean age was 47 years for the high alcohol group and 49 years for the low alcohol group. Thirteen (18%) of the participants in the high alcohol group were women compared to 27 (38%) in the low alcohol group. Body mass index and rates of positivity for HIV and hepatitis C virus were similar. Typical daily dietary iron and alcohol consumption was calculated based on a dietary questionnaire that has been validated for use among various ethnic groups (University of Hawaii). The relationship of dietary iron content and alcohol consumption with log10 serum ferritin concentration and with log10 ratio of serum ferritin to AST (ferritin/AST) was examined in multivariate linear regression models that adjusted for age, sex, ferroportin Q248H status, caloric intake and serum concentrations of CRP and ALT. Ferritin/AST has been shown to correlate with hepatic iron concentration in the setting of alcoholic liver disease. Both average daily dietary iron from meat, poulty and fish (P = 0.013) and average daily alcohol consumption (P = 0.015) correlated positively with log10 serum ferritin, but average daily non-heme iron content did not (P = 0.9). Similar findings obtained for log10 ferritin:AST. According to this modeling and holding other variables constant, a 70 kg individual with serum ferritin of 100 ng/ml associated with dietary iron from meat, poultry and fish of 3.5 mg/day would have serum ferritin of 135 ng/ml (95% c.i. 107–172) associated with dietary iron from meat, poultry and fish of 7.0 mg/day. Similarly, a 70 kg individual with serum ferritin 100 ng/ml associated with no alcohol intake would have serum ferritin 124 ng/ml (105–148) associated with alcohol consumption of 56 g/day. Our results are consistent with the hypothesis that the amount of dietary heme iron and the degree of alcohol consumption influence the amount of storage iron in the body as reflected by serum ferritin concentration.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V108.11.1551.1551
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2006
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 2
    Online Resource
    Online Resource
    Restriction of HIV-1 infection in sickle cell trait
    American Society of Hematology ; 2021
    In:  Blood Advances Vol. 5, No. 23 ( 2021-12-14), p. 4922-4934
    Details
    In: Blood Advances, American Society of Hematology, Vol. 5, No. 23 ( 2021-12-14), p. 4922-4934
    Abstract: Patients with sickle cell disease (SCD) have a lower risk for HIV-1 infection. We reported restriction of ex vivo HIV-1 infection in SCD peripheral blood mononuclear cells (PBMCs) that was due, in part, to the upregulation of antiviral, inflammatory, and hemolytic factors, including heme oxygenase-1 (HO-1). Here, we investigated whether individuals with sickle cell trait (SCT), who develop mild hemolysis, also restrict HIV-1 infection. Ex vivo infection of SCT PBMCs exhibited an approximately twofold reduction of HIV-1 replication and lower levels of HIV-1 reverse transcription products, 2-long terminal repeat circle, HIV-1 integration, and gag RNA expression. SCT PBMCs had higher HO-1 messenger RNA (mRNA) and protein levels and reduced ribonucleotide reductase 2 (RNR2) protein levels. HO-1 inhibition by tin porphyrin eliminated ex vivo HIV-1 restriction. Among Howard University clinic recruits, higher levels of HO-1 and RNR2 mRNA and lower HIV-1 env mRNA levels were found in SCT individuals living with HIV-1. To determine the population-level effect of SCT on HIV-1 prevalence, we assessed SCT among women living with HIV (WLH) in the WIHS (Women Interagency HIV-1 Study). Among WIHS African-American participants, the prevalence of SCT was lower among women with HIV compared with uninfected women (8.7% vs 14.2%; odds ratio, 0.57; 95% confidence interval, 0.36-0.92; P = .020). WIHS WLH with SCT had higher levels of CD4+/CD8+ ratios over 20 years of follow-up (P = .003) than matched WLH without SCT. Together, our findings suggest that HIV-1 restriction factors, including HO-1 and RNR2, might restrict HIV-1 infection among individuals with SCT and limit the pathogenicity of HIV.
    Type of Medium: Online Resource
    ISSN: 2473-9529 , 2473-9537
    URL: Article
    DOI: 10.1182/bloodadvances.2021004247
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2021
    detail.hit.zdb_id: 2876449-3
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