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  • American Society of Hematology  (6)
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  • American Society of Hematology  (6)
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  • 1
    Online Resource
    Online Resource
    Effect of Cyclophosphamide on the Murine Hematopoietic Stem Cell Compartment as Measured by Different Assay Techniques
    American Society of Hematology ; 1971
    In:  Blood Vol. 38, No. 6 ( 1971-12-01), p. 706-714
    Details
    In: Blood, American Society of Hematology, Vol. 38, No. 6 ( 1971-12-01), p. 706-714
    Abstract: Three different methods have been used to measure the survival of the hematopoietic stem cell pool following treatment with cyclophosphamide. Two of these systems measure the stem cell pool by its ability to proliferate and differentiate into mature progeny. In both these methods irradiated recipient mice receive syngeneic bone marrow from either normal or cyclophosphamide-treated animals. A period of time is allowed for the transplanted progenitor cells to divide and differentiate, and then the progeny produced are assayed. Ability to form red blood cells is assessed by the amount of radioactive iron incorporated into newly formed erythrocytes. Capacity for granulocyte formation is measured by peripheral white blood cell counts following endotoxin stimulation. The pool as measured by its ability to produce erythrocytic progeny appears to be more sensitive than as measured by its ability to produce granulocytic progeny. The spleen colony assay gives results similar to the assay of granulocytic progeny. These results, taken with previous data indicating decrease in erythroid precursors in spleen colonies derived from cells surviving cyclophosphamide, are interpreted as indicating a decrease in ability for erythroid differentiation in cells surviving cyclophosphamide.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V38.6.706.706
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1971
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Studies of Antigens Associated With Hodgkin’s Disease
    American Society of Hematology ; 1972
    In:  Blood Vol. 40, No. 5 ( 1972-11-01), p. 621-633
    Details
    In: Blood, American Society of Hematology, Vol. 40, No. 5 ( 1972-11-01), p. 621-633
    Abstract: Following a previous preliminary report, this study was initiated to demonstate further evidence of tumor-associated antigens in Hodgkin’s disease and to determine if these antigens are found in other pathologic states. Tumor-associated antigens are now demonstrated by three techniques in 18 Hodgkin’s invoved spleens and are not found to be present in equal concentration in normal spleens. Using immunofluorescence techniques and absorbed tumor antisera, fluorescence is demonstrated in tumors but not in the normal region of the same tumor-bearing spleen or in normal spleens. Gel diffusion with absorbed tumor antisera revealed a common precipitin band in Hodgkin’s disease not present in normal spleens or spleens from other diseases. Studies with immunoelectrophoresis have demonstrated two antigens present in the tumors in the spleen. Eighteen out of 19 Hodgkin’s tumors from the spleen have such antigens identifiable by immunoelectrophoresis with concomitant negative normal splenic controls in each case. Five out of 18 spleens from other disease states shared one of the antigens. These data confirm the presence of common tumor-associated antigens in Hodgkin’s disease, and it is postulated that at least one antigen may be a host cell reactant substance.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V40.5.621.621
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1972
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Production of Granulocytic Progeny by Transplanted Bone Marrow in Irradiated Mice
    American Society of Hematology ; 1967
    In:  Blood Vol. 30, No. 1 ( 1967-07-01), p. 103-111
    Details
    In: Blood, American Society of Hematology, Vol. 30, No. 1 ( 1967-07-01), p. 103-111
    Abstract: The production of granulocytic progeny by transplanted mouse bone marrow is described. Normal marrow is injected into lethally irradiated recipients. Seven to 9 days is allowed for stem cells in the marrow to proliferate and differentiate. The granulocytic response to a bacterial endotoxin is then measured. This response bears a linear relationship with the number of bone marrow cells injected and can be used as an assay of granulocytic progenitor cells in bone marrow.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V30.1.103.103
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1967
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Effects of Radiation on The Capacity of The Stem Cell Compartment to Differentiate into Granulocytic and Erythrocytic Progeny
    American Society of Hematology ; 1969
    In:  Blood Vol. 34, No. 2 ( 1969-08-01), p. 141-156
    Details
    In: Blood, American Society of Hematology, Vol. 34, No. 2 ( 1969-08-01), p. 141-156
    Abstract: Different methods have been used to measure the survival following radiation of the hematopoietic stem cell pool. Two of these systems measure the stem cell pool by its ability to proliferate and differentiate into mature progeny. In both methods, irradiated recipient mice receive syngeneic bone marrow. A period of time is allowed for the transplanted progenitor cells to divide and differentiate, and then the progeny produced are assayed. Ability to form red blood cells is assessed by the amount of radioactive iron incorporated into newly-formed erythrocytes. Capacity for granulocyte formation is measured by peripheral white blood cell counts following endotoxin stimulation. This latter is a granulocyte response and has been shown to be a measure of the marrow granulocyte reserve. The pool as measured by its ability to produce erythrocytic progeny appears to be more sensitive initially than as measured by its ability to produce granulocytic progeny. Erythropoietic repopulating ability begins recovery more promptly than the granulopoietic. These effects appear to be due to the host milieu rather than any direct effect of radiation on the stem cells, resulting in initial conservation of granulopoiesis relative to erythropoiesis with subsequent compensatory recovery of erythropoiesis. Because of recent evidence suggesting a common stem cell, these results are interpreted as consistent with the notion that radiation affects not only stem cell proliferation, but also the direction and extent of differentiation.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V34.2.141.141
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1969
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Granulocyte Reserve Following Radiation Therapy as Studied by the Response to a Bacterial Endotoxin
    American Society of Hematology ; 1965
    In:  Blood Vol. 25, No. 3 ( 1965-03-01), p. 310-324
    Details
    In: Blood, American Society of Hematology, Vol. 25, No. 3 ( 1965-03-01), p. 310-324
    Abstract: The granulocyte response to an intravenous injection of Pyrexal, a highly purified bacterial endotoxin was used as an assay of the marrow granulocyte reserve in patients who had received radiation therapy for various types of neoplasms. The response to the endotoxin was correlated with the amount of marrow irradiated. Only those patients with large volumes of marrow irradiated had abnormal responses to Pyrexal. No patient receiving radiation therapy to the head and neck, or thorax, or pelvis alone, regardless of dose, developed an abnormal response to Pyrexal. Early changes in the marrow granulocyte reserve were also studied in patients before, during and after radiation therapy.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V25.3.310.310
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1965
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
  • 6
    Online Resource
    Online Resource
    X-ray and Alkylating Agents Alter Differentiation of Surviving Hematopoietic Stem Cells
    American Society of Hematology ; 1971
    In:  Blood Vol. 38, No. 2 ( 1971-08-01), p. 174-183
    Details
    In: Blood, American Society of Hematology, Vol. 38, No. 2 ( 1971-08-01), p. 174-183
    Abstract: Repopulation assays indicate that erythrocyte differentiation is preferentially impaired in the progeny of progenitor cells surviving radiation or alkylating agents. This was confirmed by study of the iron incorporation into spleen colonies produced by survivors of such treatments. These colonies were characterized by a reduced size and decreased radioactive iron incorporation. Thus, it appears that radiation and alkylating agents not only affect survival of stem cells, but also alter the differentation capacities of such surviving cells.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V38.2.174.174
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1971
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
    Location Call Number Limitation Availability
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    Online Resource
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