In:
Blood, American Society of Hematology, Vol. 130, No. 25 ( 2017-12-21), p. 2786-2798
Abstract:
HNF1A deficiency in mice leads to non–cell-autonomous anemia caused by altered red blood cell (RBC) sphingolipids leading to hemolysis. Sphingosine loading of WT RBCs phenocopies osmotic fragility and high calcium of HNF1A−/− RBCs due to suppressed plasma-membrane Ca2+-ATPase.
Type of Medium:
Online Resource
ISSN:
0006-4971
,
1528-0020
DOI:
10.1182/blood-2017-03-774356
Language:
English
Publisher:
American Society of Hematology
Publication Date:
2017
detail.hit.zdb_id:
1468538-3
detail.hit.zdb_id:
80069-7
Permalink