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  • 1
    Online Resource
    Online Resource
    Variables in Demonstrating Methicillin Tolerance in Staphylococcus aureus Strains
    American Society for Microbiology ; 1982
    In:  Antimicrobial Agents and Chemotherapy Vol. 22, No. 2 ( 1982-08), p. 352-352
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 22, No. 2 ( 1982-08), p. 352-352
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.22.2.352
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1982
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Production of the Shwartzman Reaction with Microbial L Forms
    American Society for Microbiology ; 1968
    In:  Journal of Bacteriology Vol. 96, No. 3 ( 1968-09), p. 646-651
    Details
    In: Journal of Bacteriology, American Society for Microbiology, Vol. 96, No. 3 ( 1968-09), p. 646-651
    Abstract: Study of potential pathogenicity of microbial L forms was done by the localized Shwartzman reaction. Stable L forms of Proteus mirabilis served as skin preparation in rabbits for induction of Shwartzman reaction by subsequent intravenous injection of either P. mirabilis L forms or Escherichia coli endotoxin. The intensity of the reaction was positively correlated to numbers of L forms in the skin. L forms also served as the intravenous challenge. In vivo multiplication of L forms was not a prerequisite for the reaction, as it could be produced with nonviable, osmotically lysed L forms. The reaction produced with L forms in the skin was more intense than that produced with the parent bacterial form. These latter observations, coupled with the demonstration that L forms disappeared from the skin (lysed?) after 4 hr, in contrast to bacteria which were recoverable for 72 hr (duration of study), suggest release of endotoxin by L forms as a pathogenic mechanism.
    Type of Medium: Online Resource
    ISSN: 0021-9193 , 1098-5530
    URL: Article
    DOI: 10.1128/jb.96.3.646-651.1968
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1968
    detail.hit.zdb_id: 1481988-0
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Cores, Microbial Organelles Possibly Specific to Group D Streptococci
    American Society for Microbiology ; 1968
    In:  Journal of Bacteriology Vol. 96, No. 4 ( 1968-10), p. 1400-1412
    Details
    In: Journal of Bacteriology, American Society for Microbiology, Vol. 96, No. 4 ( 1968-10), p. 1400-1412
    Abstract: A long, thin, approximately cylindrical core spans the interior of cells of 24-hr cultures of all group D streptococci that were examined, five strains of Streptococcus faecalis , single strains of S. faecalis subsp. zymogenes and S. durans , and three strains of Streptococcus spp. In one strain of S. faecalis , serial section electron microscopy showed that most cells possess a core. The core is 0.10 to 0.16 μm thick and consists of a matrix and an axial array of ribosomelike particles. It resembles one of two types of cores present in a stable protoplast form of one of the S. faecalis strains. Cores were not present in single strains of S. pyogenes (β-hemolytic group A), S. agalactiae (group B), S. dysgalactiae (group C), S. equisimilis (group C), and S. mitis (viridans group) that were examined; nor were cores observed in single strains of Staphylococcus aureus, Escherichia coli , and Bacillus megaterium . Cores may be useful, therefore, in identification of group D streptococci. For preservation and rapid recognition of cores, a glutaraldehyde-osmium tetroxide sequence of fixation appears superior to the osmium tetroxide method often employed in processing bacteria for electron microscopy.
    Type of Medium: Online Resource
    ISSN: 0021-9193 , 1098-5530
    URL: Article
    DOI: 10.1128/jb.96.4.1400-1412.1968
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1968
    detail.hit.zdb_id: 1481988-0
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Comparative In Vitro Activity of Five Cephalosporins Against Lactobacilli
    American Society for Microbiology ; 1979
    In:  Antimicrobial Agents and Chemotherapy Vol. 16, No. 1 ( 1979-07), p. 112-113
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 16, No. 1 ( 1979-07), p. 112-113
    Abstract: Of five parenteral cephalosporins tested against 43 lactobacilli, cephaloridine, cefazolin, and cefamandole were the most active inhibitory and bactericidal agents. Timed-kill analysis revealed a slow bactericidal effect, with significant declines in mean minimal bactericidal concentration values at 48 h versus 24 h.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.16.1.112
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1979
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Acute Pelvic Inflammatory Disease and Clinical Response to Parenteral Doxycycline
    American Society for Microbiology ; 1975
    In:  Antimicrobial Agents and Chemotherapy Vol. 7, No. 2 ( 1975-02), p. 133-138
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 7, No. 2 ( 1975-02), p. 133-138
    Abstract: The bacteriology of acute pelvic inflammatory disease (PID) and clinical response to parenteral doxycycline were evaluated in 30 patients. Only 3 of 21 cul-de-sac cultures from PID patients were sterile, whereas all 8 normal control subjects yielded negative results ( P 〈 0.005). Poor correlation was observed between cervical and cul-de-sac cultures. Neisseria gonorrhoeae , isolated from the cervix in 17 patients (57%), was recovered from the cul-de-sac only once. Streptococcus, Peptococcus, Peptostreptococcus , coliforms, and other organisms normally present in the vagina were the predominant isolates recovered from the cul-de-sac. Parenteral doxycycline resulted in rapid resolution of signs and symptoms (within 48 h) in 20 of 27 evaluable patients (74%). In five others, signs and symptoms of infection abated within 4 days. The remaining two patients failed to respond; in both cases, adnexal masses developed during doxycycline therapy. Gonococci were eradicated from the cervix in all but one patient who, nevertheless, had a rapid defervescence of symptoms. There was no clear-cut correlation between the clinical response and in vitro susceptibility of cul-de-sac isolates to doxycycline. These data confirm the usefulness of broad-spectrum antibiotics in acute PID. Culdocentesis is a reliable means of obtaining material for the bacteriological diagnosis of acute PID; however, the pathogenetic role and relative importance of gonococci and various other bacteria in acute PID need to be clarified further.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.7.2.133
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1975
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    In Vitro Resistance of Neisseria gonorrhoeae to Metronidazole
    American Society for Microbiology ; 1974
    In:  Antimicrobial Agents and Chemotherapy Vol. 6, No. 3 ( 1974-09), p. 327-329
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 6, No. 3 ( 1974-09), p. 327-329
    Abstract: Susceptibility of 64 clinical isolates of Neisseria gonorrhoeae to metronidazole was determined by the agar dilution technique using Mueller-Hinton and chocolate agar media. All isolates were resistant to metronidazole at 12.5 μg/ml in either medium. This lack of activity of metronidazole against N. gonorrhoeae would suggest that the ability to recover N. gonorrhoeae in patients being treated with metronidazole for concurrent Trichomonas vaginalis infections should not be hampered.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.6.3.327
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1974
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Cytosine Arabinoside Therapy for Herpes Simplex Encephalitis—Clinical Experience with Six Patients
    American Society for Microbiology ; 1973
    In:  Antimicrobial Agents and Chemotherapy Vol. 3, No. 3 ( 1973-03), p. 412-417
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 3, No. 3 ( 1973-03), p. 412-417
    Abstract: Two neonates and four adults with herpes simplex virus (HSV) encephalitis were treated with cytosine arabinoside (Ara-C). A low dose of 40 to 160 mg per m 2 per day was given for 4 to 6 days by continuous intravenous infusion and, except in two cases, by intrathecal administration. In one patient, idoxuridine (IUdR) at the dose of 1 g every 4 h was also administered after 4 days of Ara-C therapy. Both neonates and two of four adults survived. Their clinical improvement was closely related in time to the onset of therapy with Ara-C (cases 1, 2, 3) and with IUdR (case 4). In one adult who died on the 27th day of illness of a massive pulmonary embolus, postmortem examination of the brain did not disclose viral inclusions, and viral culture was negative. In the other patient who died, however, brain culture postmortem was still positive for HSV despite 4 days of Ara-C therapy. Ara-C, in addition to IUdR, may be effective in HSV encephalitis treatment, but double-blind, controlled studies appear to be necessary with these agents.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.3.3.412
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1973
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 8
    Online Resource
    Online Resource
    Concentrations of Trimethoprim-Sulfamethoxazole in Blood After a Single, Large Oral Dose
    American Society for Microbiology ; 1976
    In:  Antimicrobial Agents and Chemotherapy Vol. 10, No. 3 ( 1976-09), p. 462-463
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 10, No. 3 ( 1976-09), p. 462-463
    Abstract: Concentrations of trimethoprim (TMP) and sulfamethoxazole (SMZ) in blood were determined in seven healthy volunteers after ingestion of 720 mg of TMP and 3,600 mg of SMZ (nine tablets of TMP-SMZ, 1:5 ratio) as a single oral dose. The mean levels of drug in blood achieved during the first 8 h after drug administration ranged from 6.12 to 8.32 μg/ml for TMP and 98 to 120 μg/ml for SMZ. These concentrations easily exceeded the previously reported minimal inhibitory concentrations for clinical isolates of Neisseria gonorrhoeae . The combination of TMP-SMZ given as a single, large oral dose may be a useful therapeutic regimen for patients with uncomplicated gonorrhea and susceptible microorganisms.
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/AAC.10.3.462
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1976
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    Pyelonephritis XI. Effect of Growth Phase of Streptococcus faecalis on Serum Susceptibility and Virulence
    American Society for Microbiology ; 1970
    In:  Infection and Immunity Vol. 1, No. 6 ( 1970-06), p. 532-537
    Details
    In: Infection and Immunity, American Society for Microbiology, Vol. 1, No. 6 ( 1970-06), p. 532-537
    Abstract: Rapidly growing Streptococcus faecalis was found to be markedly susceptible to the bactericidal activity of normal rat and rabbit sera, whereas stationary-phase organisms were resistant. In contrast, human serum killed neither phase organism. Further, human serum was found to interfere with killing by rabbit serum. The serosusceptible, rapidly growing organisms were less virulent than the seroresistant, stationary-phase organisms. This was tested by production of pyelonephritis in the rat after intravenous inoculation of the organism. Renal bacterial content over a period of 4 weeks was significantly less in those animals which had received rapidly growing organisms.
    Type of Medium: Online Resource
    ISSN: 0019-9567 , 1098-5522
    URL: Article
    DOI: 10.1128/iai.1.6.532-537.1970
    RVK:
    XA 10000
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1970
    detail.hit.zdb_id: 1483247-1
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  • 10
    Online Resource
    Online Resource
    Phagocytosis of Microbial L-Forms
    American Society for Microbiology ; 1972
    In:  Infection and Immunity Vol. 5, No. 6 ( 1972-06), p. 976-981
    Details
    In: Infection and Immunity, American Society for Microbiology, Vol. 5, No. 6 ( 1972-06), p. 976-981
    Abstract: Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-frms was confirmed by electron microscopy. In timed experiments, phagocytosis of a group D Streptococcus (ATCC 23241) and its L-form (T53I) were maximal at 30 min, although the bacteria were consistently better phagocyted. Phagocytosis of an Escherichia coli (strain Yale) and its L-form was also demonstrated with the same technique. The lesser phagocytosis of L-forms may be related to their lower chemotactic activity.
    Type of Medium: Online Resource
    ISSN: 0019-9567 , 1098-5522
    URL: Article
    DOI: 10.1128/iai.5.6.976-981.1972
    RVK:
    XA 10000
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 1972
    detail.hit.zdb_id: 1483247-1
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