In:
Molecular Biology of the Cell, American Society for Cell Biology (ASCB), Vol. 14, No. 8 ( 2003-08), p. 3208-3215
Abstract:
Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
Type of Medium:
Online Resource
ISSN:
1059-1524
,
1939-4586
DOI:
10.1091/mbc.e02-12-0833
Language:
English
Publisher:
American Society for Cell Biology (ASCB)
Publication Date:
2003
detail.hit.zdb_id:
1474922-1
SSG:
12
Permalink