In:
Materials Express, American Scientific Publishers, Vol. 10, No. 4 ( 2020-04-01), p. 578-584
Abstract:
It is acknowledged that hepatocellular carcinoma (HCC) cause the most cancer-associated mortality all around the world and the traditional Chinese medicine has been widely used in HCC treatment. Physalin B (PB) is the most important chemical compounds of a Chinese traditional herb, Physalis alkekengi var. franchetii . In this research, it is the first time in the world that we illustrated PB exhibits obvious apoptotic activity in SMMC-7721 and HepG2 human HCC cell lines in the does-dependent way. Moreover, decrease in mitochondrial membrane potential (MMP) was
found and the cellular reactive oxygen species (ROS) was obviously upregulated in PB-treated cell lines. Furthermore, the expression of apoptosis-associated proteins and ROS were increased after the treatment of PB, which were reversed by the inhibitor of TGF- β , NF- κ B
or PI3K/AKT signaling pathways. Therefore, PB illustrates potent anticancer activity, which might be studied as a potentiation therapeutic medicine for HCC.
Type of Medium:
Online Resource
ISSN:
2158-5849
DOI:
10.1166/mex.2020.1662
Language:
English
Publisher:
American Scientific Publishers
Publication Date:
2020
detail.hit.zdb_id:
2905325-0
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