In:
Journal of Nanoscience and Nanotechnology, American Scientific Publishers, Vol. 17, No. 7 ( 2017-07-01), p. 4618-4622
Abstract:
The most common treatment to trichomoniasis is the use of metronidazole; however several studies have shown that at least 5% of clinical cases of trichomoniasis are caused by parasites resistant to the drug. Lipophilic bismuth nanoparticles (BisBAL NPs) have an important antimicrobial
activity; however the influence of BisBAL NPs on human parasites has not been studied. The objective of this study was to determine the effect of bismuth lipophilic nanoparticles on Trichomonas vaginalis growth. The bismuth nanoparticles synthesized by colloidal method are composed
of ≥ 100 nm crystallites and have a spherical structure, agglomerating into clusters of small nanoparticles. Based on cell viability assays and fluorescence microscopy, Trichomonas vaginalis growth was inhibited with the addition of 62.5–125 μ g/mL of BisBAL NPs. Fluorescence
micrographs showed live T. vaginalis in absence of any drug treatment and after exposed for 24 h. with 500 μ g/mL of BisBAL NPs or 1.3 μ g/mL metronidazole a dark background was observed with cellular debris stain. In summary, here we present evidence for first time
of the antiparasitic activity of lipophilic bismuth nanoparticles being as effective as metronidazole to interfere with T. vaginalis growth. BisBAL nanoparticles could be an interesting alternative to treat and prevent parasitic infections.
Type of Medium:
Online Resource
ISSN:
1533-4880
DOI:
10.1166/jnn.2017.13743
Language:
English
Publisher:
American Scientific Publishers
Publication Date:
2017
SSG:
11
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