In:
Journal of Applied Physiology, American Physiological Society, Vol. 131, No. 2 ( 2021-08-01), p. 435-441
Kurzfassung:
Inert gas bubbles are widely accepted as the causative factor of decompression sickness (DCS), resulting in gas embolism and systemic inflammatory responses. The anticonvulsive ketone ester 1,3-butanediol acetoacetate diester (BD-AcAc 2 ) was reported to have the characteristics of increasing blood oxygen partial pressure (ppO 2 ) and anti-inflammation and was thought to have the potential to reduce bubble formation and alleviate the pathological process of DCS. This study aims to investigate the potential protection of BD-AcAc 2 against DCS in a rat model. A single dose of BD-AcAc 2 was administered orally to adult male rats (5 g/kg body wt), followed by pharmacokinetic analysis or simulated air dives. After decompression, signs of DCS were monitored, and blood was sampled for biochemical measurements. Blood ketosis peaked at 2 h and lasted for more than 4 h. The incidence of DCS was decreased and postponed significantly in rats treated with BD-AcAc 2 compared with those treated with saline ( P 〈 0.05). Although BD-AcAc 2 failed to reduce bubble load ( P 〉 0.05), it showed an obvious decreasing trend. BD-AcAc 2 significantly increased blood ppO 2 and ameliorated oxidative and inflammatory responses, represented by increased plasma malondialdehyde (MDA), IL-1, IL-6, and TNF-α and decreased glutathione thiol ( P 〈 0.05) levels, whereas blood pH remained unchanged ( P 〉 0.05). These results suggest that BD-AcAc 2 exerted beneficial effects on DCS rats mainly related to increasing ppO 2 and anti-inflammatory and antioxidant properties. Together with its capacity for delaying central nervous system (CNS) oxygen toxicity seizures, BD-AcAc 2 might be an ideal drug candidate for DCS prevention and treatment. NEW & NOTEWORTHY This is the first study exploring the effects of BD-AcAc 2 on DCS prevention, and it was proven to be an efficient and simple method. The role of BD-AcAc 2 in increasing ppO 2 , anti-inflammatory and antioxidant properties was thought to be the critical mechanism in DCS prevention.
Materialart:
Online-Ressource
ISSN:
8750-7587
,
1522-1601
DOI:
10.1152/japplphysiol.00035.2021
Sprache:
Englisch
Verlag:
American Physiological Society
Publikationsdatum:
2021
ZDB Id:
1404365-8
SSG:
12
SSG:
31
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