GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • American Physiological Society  (20)
  • 1
    Online Resource
    Online Resource
    Mechanisms of cell injury in rat mesentery and cremaster muscle
    American Physiological Society ; 1998
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 274, No. 3 ( 1998-03-01), p. H1009-H1015
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 274, No. 3 ( 1998-03-01), p. H1009-H1015
    Abstract: The events responsible for cell injury after a tissue stimulation are only incompletely understood. The purpose of this study was to examine mechanisms of cell injury in two tissues, rat mesentery and cremaster muscle, after tissue stimulation with N-formylmethionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF). The response was studied in the same animal in random order using normal and leukopenic rats. The tissues were exteriorized after pentobarbital anesthesia. Five to six vascularized areas were chosen in each tissue, and cell injury and hydroperoxide production were assessed visually by continuous superfusion with 1 μM propidium iodide and 5 μM dichlorofluorescin diacetate (DCFH), respectively. FMLP (1 × 10 −8 M) and then PAF (1 × 10 −8 M) were added to the superfusate, and measurements were made at several time points. The second tissue was then examined using the same protocol. In the cremaster, there was little hydroperoxide production, and the tissue injury was eliminated after leukopenia. Leukopenia had no effect on tissue injury in the mesentery. Although hydroperoxide production was observed, there was no correlation between it and the tissue injury. The level of preactivation showed no correlation with either tissue injury or hydroperoxide production. In light of these results, mast cell degranulation may be an important mechanism of tissue injury in the mesentery.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.1998.274.3.H1009
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1998
    detail.hit.zdb_id: 1477308-9
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Vasoactive properties of plasma protein fractions
    American Physiological Society ; 1964
    In:  American Journal of Physiology-Legacy Content Vol. 206, No. 4 ( 1964-04-01), p. 923-925
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 206, No. 4 ( 1964-04-01), p. 923-925
    Abstract: The capacity of plasma to potentiate norepinephrine (NOR)-induced contractions of the rabbit aortic strip can be attributed to the plasma protein fractions, perhaps almost exclusively to their albumin content. Albumin, 0.2–2 mg/15 ml, potentiated a threshold test dose of NOR from minimal to maximal effect. In the presence of albumin 1–2 mg/15 ml, the threshold dose of NOR was decreased about five to ten times. Albumin, 500 mg/15 ml, did not have a greater potentiating effect. Albumin itself had no contracting ability. The blood of the anesthetized rabbit does not contain sufficient NOR to contract the aortic strip; such concentrations of NOR even in the presence of plasma proteins or albumin were ineffective. The data suggest that NOR does not contribute directly to the maintenance of normal vascular tone.
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1964.206.4.923
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1964
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Participation of VEM and VDM Mechanisms in Drum Shock and in Development of ‘Resistance’ to Drum Trauma
    American Physiological Society ; 1950
    In:  American Journal of Physiology-Legacy Content Vol. 164, No. 1 ( 1950-12-31), p. 91-104
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 164, No. 1 ( 1950-12-31), p. 91-104
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1950.164.1.91
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1950
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    In vivo visualization of oxidative changes in microvessels during neutrophil activation
    American Physiological Society ; 1993
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 264, No. 3 ( 1993-03-01), p. H881-H891
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 264, No. 3 ( 1993-03-01), p. H881-H891
    Abstract: This study was designed to characterize temporal changes of oxidative metabolism in microvascular endothelium in vivo associated with neutrophil adhesion and diapedesis. The rat mesentery was loaded with dichlorofluorescein (DCFH) diacetate, a hydroperoxide-sensitive fluorescent probe that is trapped within viable cells as a nonfluorescent form and is converted to fluorescent dichlorofluorescein (DCF) by hydroperoxides. The fluorescent light emission was recorded with digital microscopy and its camera response was calibrated by superfusion of the mesentery with known concentrations of hydroperoxides. After rinsing with a precursor-free solution, it was possible to observe both the neutrophil adhesion and fluorescence changes in venular endothelium during superfusion with platelet-activating factor (PAF, 100 nM) by alternately changing light sources. In the PAF-treated animals, DCF fluorescence in the venular wall was markedly elevated concurrent with an increase in the number of adherent neutrophils. An onset of a significant DCF fluorescence was observed as early as 10 min after PAF application. The venular oxidative changes were co-localized with neutrophils adhering to the endothelium or migrating into the interstitium. The oxidative impact in the venular wall superfused with 100 nM PAF for 40 min was equivalent to that induced by the 10-min superfusion of 0.8 mM of tert-butyl hydroperoxide. Pretreatment with dipyridyl, an iron chelator, or dimethylthiourea, a hydroxyl radical scavenger, significantly attenuated the PAF-induced oxidative changes in the venule but had little effect on neutrophil adhesion. These findings suggest that an endothelial cell-dependent mechanism involving an iron-catalyzed reaction may have a role in enhancement of neutrophil-mediated oxidative stress in venular endothelium.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.1993.264.3.H881
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1993
    detail.hit.zdb_id: 1477308-9
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Comparison of capsule and wick techniques for measurement of interstitial fluid pressure
    American Physiological Society ; 1971
    In:  Journal of Applied Physiology Vol. 31, No. 6 ( 1971-12-01), p. 942-945
    Details
    In: Journal of Applied Physiology, American Physiological Society, Vol. 31, No. 6 ( 1971-12-01), p. 942-945
    Type of Medium: Online Resource
    ISSN: 8750-7587 , 1522-1601
    URL: Article
    DOI: 10.1152/jappl.1971.31.6.942
    RVK:
    WA 15000
    RVK:
    XA 52094
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1971
    detail.hit.zdb_id: 1404365-8
    SSG: 12
    SSG: 31
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Suppression of rabbit kidney histidine decarboxylase activity by endotoxin
    American Physiological Society ; 1963
    In:  American Journal of Physiology-Legacy Content Vol. 204, No. 3 ( 1963-03-01), p. 369-371
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 204, No. 3 ( 1963-03-01), p. 369-371
    Abstract: Previous work has shown that bacterial endotoxins activate an inducible form of histidine decarboxylase present in mammalian tissues. The product of this enzyme, induced histamine, has been postulated to have a circulatory function and to oppose the vasoconstrictor actions of the catecholamines on the small blood vessels. The present experiments show that in kidney of endotoxin-treated rabbits there is an anomalous response, histidine decarboxylase being strongly reduced, not activated. The findings are consistent with the view that suppression of induced histamine synthesis, at a time of markedly increased catecholamine release, might potentiate the actions of these vasoconstrictors on the kidney. This event may be a factor in the early endotoxin-induced changes in the glomerular capillaries which prepares them for the subsequent events of the generalized Shwartzman reaction.
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1963.204.3.369
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1963
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Regional Differences in Response of Terminal Vascular Bed to Vasoactive Agents
    American Physiological Society ; 1955
    In:  American Journal of Physiology-Legacy Content Vol. 182, No. 1 ( 1955-07-01), p. 155-165
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 182, No. 1 ( 1955-07-01), p. 155-165
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1955.182.1.155
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1955
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    CIRCULATORY REACTIONS OF RATS TRAUMATIZED IN THE NOBLE-COLLIP DRUM
    American Physiological Society ; 1943
    In:  American Journal of Physiology-Legacy Content Vol. 139, No. 1 ( 1943-05-01), p. 123-128
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 139, No. 1 ( 1943-05-01), p. 123-128
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1943.139.1.123
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1943
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    RESPONSES OF BLOOD CAPILLARIES TO ACUTE HEMORRHAGE IN THE RAT
    American Physiological Society ; 1944
    In:  American Journal of Physiology-Legacy Content Vol. 142, No. 1 ( 1944-08-01), p. 80-93
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 142, No. 1 ( 1944-08-01), p. 80-93
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1944.142.1.80
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1944
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Reticulo-Endothelial System in Relation to Drum Shock
    American Physiological Society ; 1956
    In:  American Journal of Physiology-Legacy Content Vol. 187, No. 2 ( 1956-10-31), p. 263-268
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 187, No. 2 ( 1956-10-31), p. 263-268
    Abstract: The administration of colloidal matter, sufficient to blockade the phagocytic activity of the reticulo-endothelial system (RES) in the liver and spleen of rats, has a dramatic effect on the subsequent response to drum trauma. Standardized episodes of trauma in the Noble-Collip drum become more lethal and refractory to therapeutic measures. Resistance to trauma, induced by adaptation to doses of increasing severity, is likewise attenuated by blockade of the RES. The predisposing effects were both dose- and time-dependent. The administration of cortisone in large doses (10–20 mg), an amount shown also to depress RES activity, undermines the capacity of normal rats to withstand traumatic shock, but has no such effect on trauma-resistant animals. It is suggested that the physiological adaptation to trauma may involve an altered relation of the RES to corticosteroids.
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1956.187.2.263
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1956
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...