In:
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 279, No. 2 ( 2000-08-01), p. E411-E416
Abstract:
We studied growth hormone (GH) and leptin secretion in eight male (age 29.3 ± 1.2 yr, body mass index 22.2 ± 0.5 kg/m 2 ) and seven female normal subjects (28.0 ± 0.8 yr, 20.1 ± 0.7 kg/m 2 ) before and after 36 h of fasting. In the fed state, 8-h mean GH and leptin concentrations were higher in females ( P 〈 0.05 and P 〈 0.0001, respectively). Fasting increased GH and decreased leptin in both sexes. There was significant interaction between gender and fasting ( P 〈 0.05 for GH and P 〈 0.005 for leptin). Females showed a slighter increase in GH but a more marked decrease in leptin, so that there was no significant gender-related difference in GH and leptin after fasting. Fasting did not modify insulin-like growth factor (IGF) I, IGF binding protein (IGFBP)-3, acid-labile subunit, or GH binding protein; increased IGFBP-1 and free fatty acids ( P 〈 0.0001) but decreased glucose ( P 〈 0.001) and insulin levels ( P 〈 0.05). In males, insulin levels were higher ( P 〈 0.05) in the fed state and underwent deeper reduction after fasting (interaction P 〈 0.03). In conclusion, GH and leptin secretions are higher in women than in men in the fed but not in the fasting condition, which abolishes these gender-related differences in humans.
Type of Medium:
Online Resource
ISSN:
0193-1849
,
1522-1555
DOI:
10.1152/ajpendo.2000.279.2.E411
Language:
English
Publisher:
American Physiological Society
Publication Date:
2000
detail.hit.zdb_id:
1477331-4
SSG:
12
Permalink
