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  • American Physiological Society  (3)
  • 1
    Online Resource
    Online Resource
    Effect of X-Irradiation on the Function of Adrenal Autotransplants in the Rat
    American Physiological Society ; 1957
    In:  American Journal of Physiology-Legacy Content Vol. 192, No. 1 ( 1957-12-31), p. 51-57
    Details
    In: American Journal of Physiology-Legacy Content, American Physiological Society, Vol. 192, No. 1 ( 1957-12-31), p. 51-57
    Abstract: Adrenalectomized rats having intramuscular autotransplants of adrenocortical tissue regenerated from adrenal glands x-irradiated with 2000 r in vitro immediately prior to implantation did not survive as well nor gain weight as rapidly as did control rats with nonirradiated transplants. Moreover, at 14 days after operation they were more susceptible to histamine poisoning, water intoxication and exposure to cold, having little or no advantage over adrenalectomized rats in withstanding the first two stresses. The impairment in function was correlated with reduction in mass of secreting adrenocortical tissue, and presumably decrease in circulating level of corticosteroids, resulting from delayed regeneration of the x-irradiated transplants. Rats with intramuscular transplants regenerating in sites locally x-irradiated with 2000 r just before implantation of the glands withstood histamine poisoning at 14 days after operation as well as did their controls. Rats with subcutaneous transplants in the ears x-irradiated with 2000 r at 28 days after operation (established transplants) and tested 2 weeks later responded to exposure to cold like their controls.
    Type of Medium: Online Resource
    ISSN: 0002-9513
    URL: Article
    DOI: 10.1152/ajplegacy.1957.192.1.51
    RVK:
    WA 15000
    RVK:
    XA 20060
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1957
    detail.hit.zdb_id: 1477334-X
    detail.hit.zdb_id: 2065807-2
    detail.hit.zdb_id: 1477287-5
    detail.hit.zdb_id: 1477308-9
    detail.hit.zdb_id: 1477297-8
    detail.hit.zdb_id: 1477331-4
    detail.hit.zdb_id: 1477300-4
    detail.hit.zdb_id: 1477329-6
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Electrical communication in branching arterial networks
    American Physiological Society ; 2012
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 303, No. 6 ( 2012-09-15), p. H680-H692
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 303, No. 6 ( 2012-09-15), p. H680-H692
    Abstract: Electrical communication and its role in blood flow regulation are built on an examination of charge movement in single, isolated vessels. How this process behaves in broader arterial networks remains unclear. This study examined the nature of electrical communication in arterial structures where vessel length and branching were varied. Analysis began with the deployment of an existing computational model expanded to form a variable range of vessel structures. Initial simulations revealed that focal endothelial stimulation generated electrical responses that conducted robustly along short unbranched vessels and to a lesser degree lengthened arteries or branching structures retaining a single branch point. These predictions matched functional observations from hamster mesenteric arteries and support the idea that an increased number of vascular cells attenuate conduction by augmenting electrical load. Expanding the virtual network to 31 branches revealed that electrical responses increasingly ascended from fifth- to first-order arteries when the number of stimulated distal vessels rose. This property enabled the vascular network to grade vasodilation and network perfusion as revealed through blood flow modeling. An elevation in endothelial-endothelial coupling resistance, akin to those in sepsis models, compromised this ascension of vasomotor/perfusion responses. A comparable change was not observed when the endothelium was focally disrupted to mimic disease states including atherosclerosis. In closing, this study highlights that vessel length and branching play a role in setting the conduction of electrical phenomenon along resistance arteries and within networks. It also emphasizes that modest changes in endothelial function can, under certain scenarios, impinge on network responsiveness and blood flow control.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.00261.2012
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2012
    detail.hit.zdb_id: 1477308-9
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Identification of L- and T-type Ca 2+ channels in rat cerebral arteries: role in myogenic tone development
    American Physiological Society ; 2013
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 304, No. 1 ( 2013-01-01), p. H58-H71
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 304, No. 1 ( 2013-01-01), p. H58-H71
    Abstract: L-type Ca 2+ channels are broadly expressed in arterial smooth muscle cells, and their voltage-dependent properties are important in tone development. Recent studies have noted that these Ca 2+ channels are not singularly expressed in vascular tissue and that other subtypes are likely present. In this study, we ascertained which voltage-gated Ca 2+ channels are expressed in rat cerebral arterial smooth muscle and determined their contribution to the myogenic response. mRNA analysis revealed that the α 1 -subunit of L-type (Ca v 1.2) and T-type (Ca v 3.1 and Ca v 3.2) Ca 2+ channels are present in isolated smooth muscle cells. Western blot analysis subsequently confirmed protein expression in whole arteries. With the use of patch clamp electrophysiology, nifedipine-sensitive and -insensitive Ba 2+ currents were isolated and each were shown to retain electrical characteristics consistent with L- and T-type Ca 2+ channels. The nifedipine-insensitive Ba 2+ current was blocked by mibefradil, kurtoxin, and efonidpine, T-type Ca 2+ channel inhibitors. Pressure myography revealed that L-type Ca 2+ channel inhibition reduced tone at 20 and 80 mmHg, with the greatest effect at high pressure when the vessel is depolarized. In comparison, the effect of T-type Ca 2+ channel blockade on myogenic tone was more limited, with their greatest effect at low pressure where vessels are hyperpolarized. Blood flow modeling revealed that the vasomotor responses induced by T-type Ca 2+ blockade could alter arterial flow by ∼20–50%. Overall, our findings indicate that L- and T-type Ca 2+ channels are expressed in cerebral arterial smooth muscle and can be electrically isolated from one another. Both conductances contribute to myogenic tone, although their overall contribution is unequal.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.00476.2012
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2013
    detail.hit.zdb_id: 1477308-9
    SSG: 12
    Location Call Number Limitation Availability
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    Online Resource
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