In:
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 280, No. 4 ( 2001-04-01), p. E591-E597
Abstract:
Overt nephrotic syndrome is characterized by albumin and fibrinogen hyperproduction and reduced very low density lipoprotein apolipoprotein B-100 (VLDL apoB-100) clearance. Whether similar changes also occur in low-grade proteinuria is not known. Thus we measured albumin, fibrinogen, and VLDL apoB-100 kinetics in six patients with modest proteinuria and normal creatinine clearance (P) and in ten control subjects (C) by leucine tracer infusion and precursor-product relationships. In P, plasma albumin concentration was decreased ( P 〈 0.003), whereas concentrations of fibrinogen and VLDL apoB-100 were increased ( P 〈 0.001). In P, albumin fractional secretion rate (FSR) was increased ( P 〈 0.01), fibrinogen FSR was normal, and VLDL apoB-100 FSR was decreased ( P 〈 0.03). As a result, in P, absolute secretion rates (ASR) of albumin and fibrinogen were increased ( P 〈 0.03), whereas VLDL apoB-100 ASR was normal. Albumin FSR was inversely correlated to oncotic pressure in P but not in C. These findings suggest that low-grade nephrotic proteinuria is characterized by simultaneous multiple alterations in turnover rates of albumin, fibrinogen, and VLDL apoB-100. Their pathogenesis, however, appears to be multifactorial.
Type of Medium:
Online Resource
ISSN:
0193-1849
,
1522-1555
DOI:
10.1152/ajpendo.2001.280.4.E591
Language:
English
Publisher:
American Physiological Society
Publication Date:
2001
detail.hit.zdb_id:
1477331-4
SSG:
12
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