In:
American Journal of Physiology-Endocrinology and Metabolism, American Physiological Society, Vol. 325, No. 6 ( 2023-12-01), p. E672-E681
Abstract:
Ingested galactose can enhance postexercise liver glycogen repletion when combined with glucose but effects on muscle glycogen synthesis are unknown. In this double-blind randomized study participants [7 men and 2 women; V̇o 2max : 51.1 (8.7) mL·kg −1 ·min −1 ] completed three trials of exhaustive cycling exercise followed by a 4-h recovery period, during which carbohydrates were ingested at the rate of 1.2 g·kg −1 ·h −1 comprising glucose (GLU), galactose (GAL) or galactose + glucose (GAL + GLU; 1:2 ratio). The increase in vastus lateralis skeletal-muscle glycogen concentration during recovery was higher with GLU relative to GAL + GLU [contrast: +50 mmol·(kg DM) −1 ; 95%CL 10, 89; P = 0.021] and GAL [+46 mmol·(kg DM) −1 ; 95%CL 8, 84; P = 0.024] with no difference between GAL + GLU and GAL [−3 mmol·(kg DM) −1 ; 95%CL −44, 37; P = 0.843]. Plasma glucose concentration in GLU was not significantly different vs. GAL + GLU (+ 0.41 mmol·L −1 ; 95%CL 0.13, 0.94) but was significantly lower than GAL (−0.75 mmol·L −1 ; 95%CL −1.34, −0.17) and also lower in GAL vs. GAL + GLU (−1.16 mmol· −1 ; 95%CL −1.80, −0.53). Plasma insulin was higher in GLU + GAL and GLU compared with GAL but not different between GLU + GAL and GLU. Plasma galactose concentration was higher in GAL compared with GLU (3.35 mmol·L −1 ; 95%CL 3.07, 3.63) and GAL + GLU (3.22 mmol·L −1 ; 95%CL 3.54, 2.90) with no difference between GLU + GAL (0.13 mmol·L −1 ; 95%CL −0.11, 0.37) and GLU. Compared with galactose or a galactose + glucose blend, glucose feeding was more effective in postexercise muscle glycogen synthesis. Comparable muscle glycogen synthesis was observed with galactose-glucose coingestion and exclusive galactose-only ingestion. NEW & NOTEWORTHY Postexercise galactose-glucose coingestion or exclusive galactose-only ingestion resulted in a lower rate of skeletal-muscle glycogen replenishment compared with exclusive glucose-only ingestion. Comparable muscle glycogen synthesis was observed with galactose-glucose coingestion and exclusive galactose-only ingestion.
Type of Medium:
Online Resource
ISSN:
0193-1849
,
1522-1555
DOI:
10.1152/ajpendo.00127.2022
Language:
English
Publisher:
American Physiological Society
Publication Date:
2023
detail.hit.zdb_id:
1477331-4
detail.hit.zdb_id:
603841-4
SSG:
12
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