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  • Munksgaard International Publishers  (3)
  • American Physical Society (APS)  (2)
  • oekom  (2)
  • American Society for Microbiology  (1)
  • Lippincott, Williams & Wilkins  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Skin function parameters in intensive-care patients (2005)
    Oxford, UK : Munksgaard International Publishers
    Skin research and technology 11 (2005), S. 0 
    Details
    ISSN: 1600-0846
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background/purpose: The study was performed to investigate the transepidermal water loss (TEWL) and pH-value in patients in intensive care.Methods: Forty intensive-care patients (22 men, 18 women) were included in the study. TEWL and pH-values were measured at admission, and after 24, 96 and 168 h. The areas of measurement were the forehead, the volar forearm, paraumbilical and the ventral thigh. The measurements were made under standardized environmental conditions according to the recommendations of the EMCO Group.Results: Elevated values were found on the forehead compared with the other skin areas examined. There was no significant change in mean TEWL-values in any patient in the course of the study. There was also no significant influence of TEWL at the time of admission on the prognosis. The course analysis of the mean pH-values, however, showed that patients who developed a systemic inflammatory response syndrome (SIRS) or sepsis during the further course had a higher pH-value over the entire study period.Conclusion: TEWL and the pH of the skin surface could be measured at bedside in the intensive-care unit and delivered reproducible results. These parameters appear, however, to be relevant only for subgroups of patients under intensive care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0909-725X.2005.00122.x
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    N-methyl-D-aspartate receptors influence the intracellular calcium concentration of keratinocytes (2004)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In the present study, the distribution of ionotropic glutamate receptors of the N-methyl-D-aspartate (NMDA)-receptor type was immunohistochemically demonstrated in healthy human skin (n = 22) and healthy buccal mucosa (n = 20). Moreover, the intracellular calcium concentration of HaCaT-cells and native human keratinocytes were studied under the influence of the selective agonist NMDA and the selective NMDA-antagonist MK-801.Immunohistochemical imaging of NMDA receptors in healthy epidermis showed a positive reaction in the stratum basale, spinosum and granulosum, whereby the greatest expression was observed in the granular layer. In the mucosal preparations, the distribution of NMDA receptors was observed to be equal in all cell layers. In the cell culture (HaCaT-cells), NMDA concentrations between 25 µM and 1 mM resulted in a significant increase in the number of cells showing elevated intracellular calcium concentration. This effect could be significantly reduced by prior application of MK-801 (100 µM). In supplementary tests on HaCaT-keratinocytes, blockade of the keratinocytic NMDA receptors with MK-801 suppressed the differentiation of the cells (expression of cytokeratin 10). The proliferation of cells was not influenced by NMDA.The investigations showed that glutamate receptors of the NMDA type have an influence on keratinocytic calcium concentration. This appears especially important for the differentiation of keratinocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.00200.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hyperplasia of dermal microvascular pericytes in scleroderma (2004)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Journal of cutaneous pathology 31 (2004), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Pericytes (PCs) are smooth muscle-like mural cells of capillaries and venules, which can synthesize matrix components and fibroblast-activating cytokines, and are thus potential mediators of pathological changes in scleroderma. In this study, alterations in microvessels were quantitatively imaged, taking PC into account for the first time.Methods:  Skin biopsies from systemic (12) and localized (14) scleroderma forms as well as age-, sex-, and body location-matched controls were examined with respect to capillary and venular densities as well as endothelial cell (EC) and PC counts using a newly developed (in respect of PC and EC) indirect collagen IV immunostaining-based method.Results:  Hyperplasia of the PC that doubled the microvascular PC density was the most conspicuous characteristic. In the capillaries of the upper dermal plexus of the periphery of the sclerotic zones, median ratios of PC : EC were 0.23 (controls 0.10) or 0.18 (controls 0.11) in systemic or localized scleroderma, respectively. Furthermore, an increase in capillary density in the upper dermal plexus could be demonstrated in the marginal zones of both types of disease.Conclusions:  The observed PC increase in the peripheral zones of active disease supports the hypothesis of a vascular pathogenesis of scleroderma and directs the focus to microvascular PC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2004.00203.x
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    Paper (German National Licenses)
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  • 4
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    Fluorescence-Based Quasicontinuous and In Situ Monitoring of Biofilm Formation Dynamics in Natural Marine Environments (2014)
    American Society for Microbiology
    In:  Applied and Environmental Microbiology, 80 (12). pp. 3721-3728.
    Details
    Publication Date: 2019-09-23
    Description: Analyzing the dynamics of biofilm formation helps to deepen our understanding of surface colonization in natural environments. While methods for screening biofilm formation in the laboratory are well established, studies in marine environments have so far been based upon destructive analysis of individual samples and provide only discontinuous snapshots of biofilm establishment. In order to explore the development of biofilm over time and under various biotic and abiotic conditions, we applied a recently developed optical biofilm sensor to quasicontinuously analyze marine biofilm dynamics in situ. Using this technique in combination with microscope-assisted imaging, we investigated biofilm formation from its beginning to mature multispecies biofilms. In contrast to laboratory studies on biofilm formation, a smooth transition from initial attachment to colony formation and exponential growth could not be observed in the marine environment. Instead, initial attachment was followed by an adaptation phase of low growth and homogeneously distributed solitary bacterial cells. Moreover, we observed a diurnal variation of biofilm signal intensity, suggesting a transient state of biofilm formation of bacteria. Overall, the biofilm formation dynamics could be modeled by three consecutive development stages attributed to initial bacterial attachment, bacterial growth, and attachment and growth of unicellular eukaryotic microorganisms. Additional experiments showed that the presence of seaweed considerably shortened the adaptation phase in comparison with that on control surfaces but yielded similar growth rates. The outlined examples highlight the advantages of a quasicontinuous in situ detection that enabled, for the first time, the exploration of the initial attachment phase and the diurnal variation during biofilm formation in natural ecosystems
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1128/AEM.00298-14
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 5
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    Large Scale Association Analysis of Novel Genetic Loci for Coronary Artery Disease (2009)
    Lippincott, Williams & Wilkins
    In:  Arteriosclerosis Thrombosis and Vascular Biology, 29 (5). 774-U356.
    Details
    Publication Date: 2019-01-21
    Description: Background-Combined analysis of 2 genome-wide association studies in cases enriched for family history recently identified 7 loci (on 1p13.3, 1q41, 2q36.3, 6q25.1, 9p21, 10q11.21, and 15q22.33) that may affect risk of coronary artery disease (CAD). Apart from the 9p21 locus, the other loci await substantive replication. Furthermore, the effect of these loci on CAD risk in a broader range of individuals remains to be determined.Methods and Results-We undertook association analysis of single nucleotide polymorphisms at each locus with CAD risk in 11 550 cases and 11 205 controls from 9 European studies. The 9p21.3 locus showed unequivocal association (rs1333049, combined odds ratio [OR]=1.20, 95% CI [1.16 to 1.25], probability value=2.81x10(-21)). We also confirmed association signals at 1p13.3 (rs599839, OR=1.13 [1.08 to 1.19], P=1.44x10(-7)), 1q41 (rs3008621, OR=1.10 [1.04 to 1.17], P=1.02x10(-3)), and 10q11.21 (rs501120, OR=1.11 [1.05 to 1.18], P=4.34x10(-4)). The associations with 6q25.1 (rs6922269, P=0.020) and 2q36.3 (rs2943634, P=0.032) were borderline and not statistically significant after correction for multiple testing. The 15q22.33 locus did not replicate. The 10q11.21 locus showed a possible sex interaction (P = 0.015), with a significant effect in women (OR=1.29 [1.15 to 1.45], P=1.86x10(-5)) but not men (OR=1.03 [0.96 to 1.11], P=0.387). There were no other strong interactions of any of the loci with other traditional risk factors. The loci at 9p21, 1p13.3, 2q36.3, and 10q11.21 acted independently and cumulatively increased CAD risk by 15% (12% to 18%), per additional risk allele. ConclusionsThe findings provide strong evidence for association between at least 4 genetic loci and CAD risk. Cumulatively, these novel loci have a significant impact on risk of CAD at least in European populations. (Arterioscler Thromb Vasc Biol. 2009; 29: 774-780.)
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1161/ATVBAHA.108.181388
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 6
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    Short-distance breakdown of the Higgs mechanism and the robustness of the BCS theory for charged superconductors (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-02-16
    Description: Author(s): Sonja Fischer, Matthias Hecker, Mareike Hoyer, and Jörg Schmalian Through the Higgs mechanism, the long-range Coulomb interaction eliminates the low-energy Goldstone phase mode in superconductors and transfers spectral weight all the way up to the plasma frequency. Here, we show that the Higgs mechanism breaks down for length scales shorter than the superconductin... [Phys. Rev. B 97, 054510] Published Thu Feb 15, 2018
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    The Growth-Welfare Dialectic: What Might Hegel Say? (2016)
    oekom
    Details
    Publication Date: 2016-07-15
    Description: This article is currently available as a free download on Ingenta Connect
    Print ISSN: 0940-5550
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Philosophy
    Published by oekom
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  • 8
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    Design It! Solving Sustainability Problems by Applying Design Thinking (2015)
    oekom
    Details
    Publication Date: 2015-10-17
    Print ISSN: 0940-5550
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Philosophy
    Published by oekom
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  • 9
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    Analysis of magnetic random telegraph noise in individual arrangements of a small number of coupled MnAs nanoclusters (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-10-07
    Description: Author(s): Martin Fischer, Matthias T. Elm, Hiroaki Kato, Shinya Sakita, Shinjiro Hara, and Peter J. Klar The temporal dependence of the resistance of MnAs nanocluster arrangements grown by selective-area metal-organic vapor-phase epitaxy is investigated at different temperatures. The resistance of such arrangements exhibits random telegraph noise with jumps between discrete resistance levels. The effec… [Phys. Rev. B 92, 165306] Published Tue Oct 06, 2015
    Keywords: Semiconductors II: surfaces, interfaces, microstructures, and related topics
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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