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  • Articles  (2)
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  • American Meteorological Society  (1)
  • Springer  (1)
  • 1
    ISSN: 1420-908X
    Keywords: Silica ; Lung ; Inflammation ; Dexamethasone ; Peroxynitrite ; Chemiluminescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhalation of silica has been shown to produce a dramatic inflammatory and toxic response within the lungs of humans and laboratory animals. Currently, no effective treatment exists for workers who may have been exposed to the inhalation of silica. The objective of this study was to develop an animal model in which we could evaluate the effect that anti-inflammatory steroids have on the acute silica-induced pulmonary inflammatory response. Male Fischer 344 rats were pretreated with either dexamethasone (2 mg/kg) or saline vehicle (i.p.) on days 1, 3, and 5. On day 6, the animals from the two groups were then intratracheally instilled with either silica (20 mg/0.5 ml saline vehicle) or saline vehicle (0.5 ml). Twenty-four hours after the instillations in the non-steroid group, significant increases occurred in total protein, total number of cells, neutrophils, and lymphocytes recovered from the lungs of animals treated with silica compared to saline controls. Silica also caused dramatic increases in the luminol-dependent chemiluminescence (LDCL) of lung tissue and bronchoalveolar lavage (BAL) cells. The LDCL reaction was markedly decreased by either superoxide dismutase (SOD) orN-nitro-l-arginine methyl ester hydrochloride (l-NAME). SOD is involved in the enzymatic breakdown of superoxide anion, whilel-NAME, a nitric oxide (NO) synthase inhibitor, prevents the formation of NO. When the superoxide anion and NO react, they form the highly oxidizing substance peroxynitrite. This study then implicates peroxynitrite as an agent which may be involved in the silica-induced oxidant lung injury. When the animals were pretreated with the steroid dexamethasone, there was a complete protection against the biochemical, cellular, and chemiluminescent indices of damage caused by silica. The mechanism in which the steroid protects the lung from damage may be due to the ability of dexamethasone to block the induction of NO synthase. With further study in animals, the anti-inflammatory steroids may be useful in the treatment of silicainduced lung injury.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2019. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 32(8), (2019): 2185-2205. doi:10.1175/JCLI-D-18-0538.1.
    Description: Much attention has been paid to the climatic impacts of changes in the Kuroshio Extension, instead of the Kuroshio in the East China Sea (ECS). This study, however, reveals the prominent influences of the lateral shift of the Kuroshio at interannual time scale in late spring [April–June (AMJ)] on the sea surface temperature (SST) and precipitation in summer around the ECS, based on high-resolution satellite observations and ERA-Interim. A persistent offshore displacement of the Kuroshio during AMJ can result in cold SST anomalies in the northern ECS and the Japan/East Sea until late summer, which correspondingly causes anomalous cooling of the lower troposphere. Consequently, the anomalous cold SST in the northern ECS acts as a key driver to robustly enhance the precipitation from the Yangtze River delta to Kyushu in early summer (May–August) and over the central ECS in late summer (July–September). In view of the moisture budget analysis, two different physical processes modulated by the lateral shift of the Kuroshio are identified to account for the distinct responses of precipitation in early and late summer, respectively. First, the anomalous cold SST in the northern ECS induced by the Kuroshio offshore shift is likely conducive to the earlier arrival of the mei-yu–baiu front at 30°–32°N and its subsequent slower northward movement, which may prolong the local rainy season, leading to the increased rain belt in early summer. Second, the persistent cold SST anomalies in late summer strengthen the near-surface baroclinicity and the associated strong atmospheric fronts embedded in the extratropical cyclones over the central ECS, which in turn enhances the local rainfall.
    Description: We appreciate three anonymous reviewers for their thoughtful and constructive comments. This work is supported by the National Key Research and Development Program of China (2016YFA0601804), the National Natural Science Foundation of China (NSFC) Projects (91858102, 41490643, 41490640, 41506009, U1606402) and the OUC–WHOI joint research program (21366).
    Description: 2019-10-01
    Keywords: Continental shelf/slope ; Atmosphere-ocean interaction ; Boundary currents ; Precipitation ; Interannual variability
    Repository Name: Woods Hole Open Access Server
    Type: Article
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